ID   SF3B5_BOVIN             Reviewed;          86 AA.
AC   Q56K13;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Splicing factor 3B subunit 5;
DE            Short=SF3b5;
DE   AltName: Full=Pre-mRNA-splicing factor SF3b 10 kDa subunit;
GN   Name=SF3B5;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lymphoid epithelium;
RA   Yu J., Meng Y., Wang Z., Hansen C., Li C., Moore S.S.;
RT   "Analysis of sequences obtained from constructed full-length bovine cDNA
RT   libraries.";
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in pre-mRNA splicing as a component of the splicing
CC       factor SF3B complex, a constituent of the spliceosome. SF3B complex is
CC       required for 'A' complex assembly formed by the stable binding of U2
CC       snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence
CC       independent binding of SF3A/SF3B complex upstream of the branch site is
CC       essential, it may anchor U2 snRNP to the pre-mRNA.
CC       {ECO:0000250|UniProtKB:Q9BWJ5}.
CC   -!- SUBUNIT: Component of the spliceosome B complex. Component of splicing
CC       factor SF3B complex which is composed of at least eight subunits;
CC       SF3B1, SF3B2, SF3B3, SF3B4, SF3B5, SF3B6, PHF5A and DDX42. SF3B
CC       associates with the splicing factor SF3A and a 12S RNA unit to form the
CC       U2 small nuclear ribonucleoproteins complex (U2 snRNP). Within the SF3B
CC       complex interacts directly with SF3B1 (via HEAT domain) and SF3B3. The
CC       SF3B complex composed of SF3B1, SF3B2, SF3B3, SF3B4, SF3B5, SF3B6 and
CC       PHF5A interacts with U2AF2. Component of the U11/U12 snRNPs that are
CC       part of the U12-type spliceosome. {ECO:0000250|UniProtKB:Q9BWJ5}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BWJ5}.
CC   -!- SIMILARITY: Belongs to the SF3B5 family. {ECO:0000305}.
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DR   EMBL; AY911314; AAW82082.1; -; mRNA.
DR   EMBL; BC111655; AAI11656.1; -; mRNA.
DR   RefSeq; NP_001020521.1; NM_001025350.3.
DR   RefSeq; XP_005211072.1; XM_005211015.3.
DR   AlphaFoldDB; Q56K13; -.
DR   SMR; Q56K13; -.
DR   STRING; 9913.ENSBTAP00000012920; -.
DR   PaxDb; Q56K13; -.
DR   PRIDE; Q56K13; -.
DR   Ensembl; ENSBTAT00000012920; ENSBTAP00000012920; ENSBTAG00000009795.
DR   GeneID; 574400; -.
DR   KEGG; bta:574400; -.
DR   CTD; 83443; -.
DR   VEuPathDB; HostDB:ENSBTAG00000009795; -.
DR   VGNC; VGNC:34512; SF3B5.
DR   eggNOG; KOG3485; Eukaryota.
DR   GeneTree; ENSGT00390000013215; -.
DR   HOGENOM; CLU_138804_3_1_1; -.
DR   InParanoid; Q56K13; -.
DR   OMA; PMLSYMA; -.
DR   OrthoDB; 1632322at2759; -.
DR   TreeFam; TF300117; -.
DR   Proteomes; UP000009136; Chromosome 9.
DR   Bgee; ENSBTAG00000009795; Expressed in oocyte and 107 other tissues.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0071011; C:precatalytic spliceosome; IBA:GO_Central.
DR   GO; GO:0005689; C:U12-type spliceosomal complex; IEA:Ensembl.
DR   GO; GO:0005686; C:U2 snRNP; IBA:GO_Central.
DR   GO; GO:0071005; C:U2-type precatalytic spliceosome; ISS:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:1990935; F:splicing factor binding; IEA:Ensembl.
DR   GO; GO:0035522; P:monoubiquitinated histone H2A deubiquitination; IEA:Ensembl.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
DR   InterPro; IPR009846; SF3b5/RDS3-10.
DR   InterPro; IPR017089; Splicing_factor_3B_subunit_5.
DR   PANTHER; PTHR20978; PTHR20978; 1.
DR   Pfam; PF07189; SF3b10; 1.
DR   PIRSF; PIRSF037010; Splicing_factor_3B_subunit_5; 1.
PE   3: Inferred from homology;
KW   Acetylation; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein;
KW   Reference proteome; RNA-binding; Spliceosome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BWJ5"
FT   CHAIN           2..86
FT                   /note="Splicing factor 3B subunit 5"
FT                   /id="PRO_0000240345"
FT   REGION          15..76
FT                   /note="Interaction with SF3B1 and SF3B3"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BWJ5"
FT   SITE            5
FT                   /note="Interaction with RNA"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BWJ5"
FT   SITE            20
FT                   /note="Interaction with RNA"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BWJ5"
FT   MOD_RES         2
FT                   /note="N-acetylthreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BWJ5"
FT   MOD_RES         9
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BWJ5"
FT   MOD_RES         17
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BWJ5"
SQ   SEQUENCE   86 AA;  10135 MW;  B8A209EA9F548E8E CRC64;
     MTDRYTIHSQ LEHLQSKYIG TGHADTTKWE WLVNQHRDSY CSYMGHFDLL NYFAIAENES
     KARVRFNLME KMLQPCGPPA DKPEEN