ID   SF3B5_DICDI             Reviewed;          94 AA.
AC   Q55BF5;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Splicing factor 3B subunit 5;
DE            Short=SF3b5;
DE   AltName: Full=Pre-mRNA-splicing factor SF3b 10 kDa subunit homolog;
GN   Name=sf3b5; ORFNames=DDB_G0271312;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Involved in pre-mRNA splicing as a component of the splicing
CC       factor SF3B complex, a constituent of the spliceosome. SF3B complex is
CC       required for 'A' complex assembly formed by the stable binding of U2
CC       snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence
CC       independent binding of SF3A/SF3B complex upstream of the branch site is
CC       essential, it may anchor U2 snRNP to the pre-mRNA.
CC       {ECO:0000250|UniProtKB:Q9BWJ5}.
CC   -!- SUBUNIT: Component of the spliceosome B complex. Component of splicing
CC       factor SF3B complex which is composed of at least eight subunits. SF3B
CC       associates with the splicing factor SF3A and a 12S RNA unit to form the
CC       U2 small nuclear ribonucleoproteins complex (U2 snRNP).
CC       {ECO:0000250|UniProtKB:Q9BWJ5}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BWJ5}.
CC   -!- SIMILARITY: Belongs to the SF3B5 family. {ECO:0000305}.
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DR   EMBL; AAFI02000006; EAL71786.1; -; Genomic_DNA.
DR   RefSeq; XP_645657.1; XM_640565.1.
DR   AlphaFoldDB; Q55BF5; -.
DR   SMR; Q55BF5; -.
DR   STRING; 44689.DDB0233174; -.
DR   PaxDb; Q55BF5; -.
DR   EnsemblProtists; EAL71786; EAL71786; DDB_G0271312.
DR   GeneID; 8617849; -.
DR   KEGG; ddi:DDB_G0271312; -.
DR   dictyBase; DDB_G0271312; sf3b5.
DR   eggNOG; KOG3485; Eukaryota.
DR   HOGENOM; CLU_138804_4_0_1; -.
DR   InParanoid; Q55BF5; -.
DR   OMA; PMLSYMA; -.
DR   PhylomeDB; Q55BF5; -.
DR   Reactome; R-DDI-72163; mRNA Splicing - Major Pathway.
DR   Reactome; R-DDI-72165; mRNA Splicing - Minor Pathway.
DR   PRO; PR:Q55BF5; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0071011; C:precatalytic spliceosome; IBA:GO_Central.
DR   GO; GO:0005686; C:U2 snRNP; ISS:dictyBase.
DR   GO; GO:0071005; C:U2-type precatalytic spliceosome; ISS:UniProtKB.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; ISS:UniProtKB.
DR   InterPro; IPR009846; SF3b5/RDS3-10.
DR   InterPro; IPR017089; Splicing_factor_3B_subunit_5.
DR   PANTHER; PTHR20978; PTHR20978; 1.
DR   Pfam; PF07189; SF3b10; 1.
DR   PIRSF; PIRSF037010; Splicing_factor_3B_subunit_5; 1.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Spliceosome.
FT   CHAIN           1..94
FT                   /note="Splicing factor 3B subunit 5"
FT                   /id="PRO_0000328463"
FT   REGION          75..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   94 AA;  10709 MW;  4082EF78D2F1DD39 CRC64;
     MSERESLNSQ LEHLQMRYVG TGHADISKHE WLTNQHRDSL SSFIGHSSFL SLFSIAENES
     VGRVRYNTLT KMISPCGPAP KIKDNTMDKE EKND