ID   SFAH_ECOL5              Reviewed;         299 AA.
AC   P13431; Q0TL47;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2004, sequence version 2.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=S-fimbrial protein subunit SfaH;
GN   Name=sfaH; OrderedLocusNames=ECP_0299;
OS   Escherichia coli O6:K15:H31 (strain 536 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=362663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION, IDENTIFICATION IN
RP   FIMBRIAE COMPLEX, AND DISRUPTION PHENOTYPE.
RX   PubMed=2576095; DOI=10.1111/j.1365-2958.1989.tb00159.x;
RA   Schmoll T., Hoschuetzky H., Morschhaeuser J., Lottspeich F., Jann K.,
RA   Hacker J.;
RT   "Analysis of genes coding for the sialic acid-binding adhesin and two other
RT   minor fimbrial subunits of the S-fimbrial adhesin determinant of
RT   Escherichia coli.";
RL   Mol. Microbiol. 3:1735-1744(1989).
RN   [2]
RP   SEQUENCE REVISION.
RX   PubMed=11401961; DOI=10.1128/iai.69.7.4248-4256.2001;
RA   Dobrindt U., Blum-Oehler G., Hartsch T., Gottschalk G., Ron E.Z.,
RA   Fuenfstueck R., Hacker J.;
RT   "S-fimbria-encoding determinant sfa(I) is located on pathogenicity island
RT   III(536) of uropathogenic Escherichia coli strain 536.";
RL   Infect. Immun. 69:4248-4256(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=12379716; DOI=10.1128/iai.70.11.6365-6372.2002;
RA   Dobrindt U., Blum-Oehler G., Nagy G., Schneider G., Johann A.,
RA   Gottschalk G., Hacker J.;
RT   "Genetic structure and distribution of four pathogenicity islands (PAI
RT   I(536) to PAI IV(536)) of uropathogenic Escherichia coli strain 536.";
RL   Infect. Immun. 70:6365-6372(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=536 / UPEC;
RX   PubMed=16879640; DOI=10.1111/j.1365-2958.2006.05255.x;
RA   Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U.,
RA   Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J.;
RT   "Role of pathogenicity island-associated integrases in the genome
RT   plasticity of uropathogenic Escherichia coli strain 536.";
RL   Mol. Microbiol. 61:584-595(2006).
CC   -!- FUNCTION: Fimbriae (also called pili), polar filaments radiating from
CC       the surface of the bacterium to a length of 0.5-1.5 micrometers and
CC       numbering 100-300 per cell, enable bacteria to colonize the epithelium
CC       of specific host organs.
CC   -!- FUNCTION: A minor fimbrial subunit. This protein is necessary for full
CC       expression of S-specific binding. S-fimbrial adhesins enable pathogenic
CC       E.coli causing urinary-tract infections or newborn meningitis to attach
CC       to glycoproteins terminating with alpha-sialic acid-(2-3)-beta-Gal.
CC   -!- SUBCELLULAR LOCATION: Fimbrium {ECO:0000269|PubMed:2576095}.
CC   -!- DISRUPTION PHENOTYPE: Deletion decreases hemagglutination and
CC       fimbriation levels. {ECO:0000269|PubMed:2576095}.
CC   -!- SIMILARITY: Belongs to the fimbrial protein family. {ECO:0000305}.
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DR   EMBL; X16664; CAA34654.2; -; Genomic_DNA.
DR   EMBL; CP000247; ABG68334.1; -; Genomic_DNA.
DR   PIR; S15927; S15927.
DR   AlphaFoldDB; P13431; -.
DR   SMR; P13431; -.
DR   STRING; 362663.ECP_0299; -.
DR   EnsemblBacteria; ABG68334; ABG68334; ECP_0299.
DR   KEGG; ecp:ECP_0299; -.
DR   HOGENOM; CLU_080390_0_0_6; -.
DR   OMA; TNDVHIQ; -.
DR   Proteomes; UP000009182; Chromosome.
DR   GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   CDD; cd10466; FimH_man-bind; 1.
DR   Gene3D; 2.60.40.1090; -; 2.
DR   InterPro; IPR000259; Adhesion_dom_fimbrial.
DR   InterPro; IPR036937; Adhesion_dom_fimbrial_sf.
DR   InterPro; IPR008966; Adhesion_dom_sf.
DR   InterPro; IPR015243; FimH_man-bd.
DR   Pfam; PF00419; Fimbrial; 1.
DR   Pfam; PF09160; FimH_man-bind; 1.
DR   SUPFAM; SSF49401; SSF49401; 2.
PE   1: Evidence at protein level;
KW   Fimbrium.
FT   CHAIN           1..299
FT                   /note="S-fimbrial protein subunit SfaH"
FT                   /id="PRO_0000196350"
SQ   SEQUENCE   299 AA;  32032 MW;  AE66CF74ABE3050B CRC64;
     MAYSQPSFAL LCRNNQTGQE FNSGDTSFRV NVSPVVQYDK SISVLDLSQL VSCQNEDSTG
     QNYDYLKILK GSGFSPALDT KTYGRLDFTS RPTGYARQLP LQFDLQVTEA FYQYGVWKPF
     PAKLYLYPEP GVFGKVINNG DLLATLYVNK FSTKGQEAGE RNFTWRFYAT NDVHIQTGTC
     RVSSNNVKVD LPSYPGGPVT VPLTVRCDQT QSVSYTLSGP VTGSGNTVFA NTAASGAGGV
     GVQLSDKAGP VPAGQPRSLG QVGSSPVSLG LKASYALTGQ ASLTPGAVQS VINVTFSYN