SFC1_ARATH
ID SFC1_ARATH Reviewed; 309 AA.
AC Q9M038; Q8LAN8;
DT 09-JAN-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Mitochondrial succinate-fumarate transporter 1;
DE Short=AtMSFC1;
GN Name=SFC1; OrderedLocusNames=At5g01340; ORFNames=T10O8.50;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=12527366; DOI=10.1016/s0014-5793(02)03782-1;
RA Catoni E., Schwab R., Hilpert M., Desimone M., Schwacke R., Fluegge U.I.,
RA Schumacher K., Frommer W.B.;
RT "Identification of an Arabidopsis mitochondrial succinate-fumarate
RT translocator.";
RL FEBS Lett. 534:87-92(2003).
RN [6]
RP GENE FAMILY.
RX PubMed=15003237; DOI=10.1016/j.tplants.2004.01.007;
RA Picault N., Hodges M., Palmieri L., Palmieri F.;
RT "The growing family of mitochondrial carriers in Arabidopsis.";
RL Trends Plant Sci. 9:138-146(2004).
CC -!- FUNCTION: May transport cytoplasmic succinate, derived from fatty acid
CC oxidation, into the mitochondrial matrix in exchange of fumarate during
CC lipid mobilization in seed germination. Conversion of seed-reserved
CC triacylglycerols into sucrose is necessary for growth before the onset
CC of photosynthesis and involves fatty acid beta-oxidation, the
CC glyoxylate cycle and gluconeogenesis. {ECO:0000269|PubMed:12527366}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in root tips, cotyledons, hypocotyls,
CC leaves, trichomes, stems, flowers, carpels, anthers, pollen and
CC abcission zone of siliques. {ECO:0000269|PubMed:12527366}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM65239.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AL161746; CAB81917.1; -; Genomic_DNA.
DR EMBL; CP002688; AED90329.1; -; Genomic_DNA.
DR EMBL; AY052716; AAK96620.1; -; mRNA.
DR EMBL; AY098957; AAM19967.1; -; mRNA.
DR EMBL; AY087702; AAM65239.1; ALT_INIT; mRNA.
DR PIR; T48156; T48156.
DR RefSeq; NP_195754.1; NM_120212.3.
DR AlphaFoldDB; Q9M038; -.
DR SMR; Q9M038; -.
DR BioGRID; 16755; 1.
DR STRING; 3702.AT5G01340.1; -.
DR PaxDb; Q9M038; -.
DR PRIDE; Q9M038; -.
DR ProteomicsDB; 232583; -.
DR DNASU; 831479; -.
DR EnsemblPlants; AT5G01340.1; AT5G01340.1; AT5G01340.
DR GeneID; 831479; -.
DR Gramene; AT5G01340.1; AT5G01340.1; AT5G01340.
DR KEGG; ath:AT5G01340; -.
DR Araport; AT5G01340; -.
DR TAIR; locus:2179152; AT5G01340.
DR eggNOG; KOG0756; Eukaryota.
DR HOGENOM; CLU_015166_5_0_1; -.
DR InParanoid; Q9M038; -.
DR OMA; MLLVFDY; -.
DR OrthoDB; 945010at2759; -.
DR PhylomeDB; Q9M038; -.
DR PRO; PR:Q9M038; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9M038; baseline and differential.
DR Genevisible; Q9M038; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031966; C:mitochondrial membrane; IDA:TAIR.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0015141; F:succinate transmembrane transporter activity; IGI:TAIR.
DR GO; GO:0005469; F:succinate:fumarate antiporter activity; IBA:GO_Central.
DR GO; GO:0015742; P:alpha-ketoglutarate transport; IDA:TAIR.
DR GO; GO:0015746; P:citrate transport; IDA:TAIR.
DR GO; GO:0015741; P:fumarate transport; IBA:GO_Central.
DR GO; GO:0015743; P:malate transport; IDA:TAIR.
DR GO; GO:0015744; P:succinate transport; IDA:TAIR.
DR Gene3D; 1.50.40.10; -; 1.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR Pfam; PF00153; Mito_carr; 3.
DR SUPFAM; SSF103506; SSF103506; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..309
FT /note="Mitochondrial succinate-fumarate transporter 1"
FT /id="PRO_0000420760"
FT TRANSMEM 17..37
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 111..131
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..234
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT REPEAT 11..96
FT /note="Solcar 1"
FT REPEAT 108..196
FT /note="Solcar 2"
FT REPEAT 208..298
FT /note="Solcar 3"
FT CONFLICT 58
FT /note="K -> T (in Ref. 4; AAM65239)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 309 AA; 33991 MW; 6888B8D99E22357C CRC64;
MATRTESKKQ IPPYMKAVSG SLGGVVEACC LQPIDVIKTR LQLDRVGAYK GIAHCGSKVV
RTEGVRALWK GLTPFATHLT LKYTLRMGSN AMFQTAFKDS ETGKVSNRGR FLSGFGAGVL
EALAIVTPFE VVKIRLQQQK GLSPELFKYK GPIHCARTIV REESILGLWS GAAPTVMRNG
TNQAVMFTAK NAFDILLWNK HEGDGKILQP WQSMISGFLA GTAGPFCTGP FDVVKTRLMA
QSRDSEGGIR YKGMVHAIRT IYAEEGLVAL WRGLLPRLMR IPPGQAIMWA VADQVTGLYE
MRYLRNAPL
