SFC7_SCHPO
ID SFC7_SCHPO Reviewed; 120 AA.
AC A6X980;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Transcription factor tau subunit sfc7;
DE AltName: Full=TFIIIC subunit sfc7;
DE AltName: Full=Transcription factor C subunit 7;
GN Name=sfc7 {ECO:0000312|EMBL:CAO77650.1};
GN Synonyms=tfc7 {ECO:0000250|UniProtKB:Q12415}; ORFNames=SPAC1250.07;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1] {ECO:0000312|EMBL:CAO77650.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2] {ECO:0000305}
RP SIMILARITY WITH YEAST TFC7.
RX PubMed=17409385; DOI=10.1074/jbc.m611542200;
RA Dumay-Odelot H., Marck C., Durrieu-Gaillard S., Lefebvre O., Jourdain S.,
RA Prochazkova M., Pflieger A., Teichmann M.;
RT "Identification, molecular cloning, and characterization of the sixth
RT subunit of human transcription factor TFIIIC.";
RL J. Biol. Chem. 282:17179-17189(2007).
CC -!- FUNCTION: TFIIIC mediates tRNA and 5S RNA gene activation by binding to
CC intragenic promoter elements. Upstream of the transcription start site,
CC TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is
CC sufficient for RNA polymerase III recruitment and function. Part of the
CC tauA domain of TFIIIC that binds boxA DNA promoter sites of tRNA and
CC similar genes (By similarity). {ECO:0000250|UniProtKB:Q12415}.
CC -!- SUBUNIT: Component of the TFIIIC complex including sfc1, sfc3, sfc4,
CC sfc6 and sfc7. The subunits are organized in two globular domains, tauA
CC and tauB, connected by a proteolysis-sensitive and flexible linker (By
CC similarity). {ECO:0000250|UniProtKB:Q12415, ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q12415}.
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DR EMBL; CU329670; CAO77650.1; -; Genomic_DNA.
DR RefSeq; XP_001713116.1; XM_001713064.1.
DR PDB; 4BJJ; X-ray; 2.40 A; B=2-101.
DR PDBsum; 4BJJ; -.
DR AlphaFoldDB; A6X980; -.
DR SMR; A6X980; -.
DR BioGRID; 858112; 3.
DR STRING; 4896.SPAC1250.07.1; -.
DR iPTMnet; A6X980; -.
DR PaxDb; A6X980; -.
DR PRIDE; A6X980; -.
DR EnsemblFungi; SPAC1250.07.1; SPAC1250.07.1:pep; SPAC1250.07.
DR PomBase; SPAC1250.07; sfc7.
DR VEuPathDB; FungiDB:SPAC1250.07; -.
DR HOGENOM; CLU_2051004_0_0_1; -.
DR InParanoid; A6X980; -.
DR Reactome; R-SPO-76061; RNA Polymerase III Transcription Initiation From Type 1 Promoter.
DR Reactome; R-SPO-76066; RNA Polymerase III Transcription Initiation From Type 2 Promoter.
DR PRO; PR:A6X980; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005634; C:nucleus; IC:PomBase.
DR GO; GO:0000127; C:transcription factor TFIIIC complex; ISO:PomBase.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000995; F:RNA polymerase III general transcription initiation factor activity; ISO:PomBase.
DR GO; GO:0006383; P:transcription by RNA polymerase III; IBA:GO_Central.
DR GO; GO:0006384; P:transcription initiation from RNA polymerase III promoter; ISO:PomBase.
DR InterPro; IPR019481; TFIIIC_triple_barrel.
DR Pfam; PF10419; TFIIIC_sub6; 1.
PE 1: Evidence at protein level;
KW 3D-structure; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..120
FT /note="Transcription factor tau subunit sfc7"
FT /id="PRO_0000307346"
FT REGION 96..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT STRAND 15..24
FT /evidence="ECO:0007829|PDB:4BJJ"
FT STRAND 34..38
FT /evidence="ECO:0007829|PDB:4BJJ"
FT STRAND 42..44
FT /evidence="ECO:0007829|PDB:4BJJ"
FT STRAND 46..49
FT /evidence="ECO:0007829|PDB:4BJJ"
FT STRAND 52..59
FT /evidence="ECO:0007829|PDB:4BJJ"
FT STRAND 62..69
FT /evidence="ECO:0007829|PDB:4BJJ"
FT STRAND 81..83
FT /evidence="ECO:0007829|PDB:4BJJ"
FT STRAND 87..93
FT /evidence="ECO:0007829|PDB:4BJJ"
SQ SEQUENCE 120 AA; 13324 MW; 199D8755F8850109 CRC64;
MSSNSPSLET DVDDVENIVF QFQNSSLDFQ SSDDFSILGI DQPHPIVRIG GMFFRGTWHQ
PIGTDIVVPS VNDSELSRDG LVLCKRRLML EQIRLVPKNP SPSSSIHSPT QGEPENISEN
