SFH10_ARATH
ID SFH10_ARATH Reviewed; 558 AA.
AC Q9SI13;
DT 18-SEP-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 113.
DE RecName: Full=Phosphatidylinositol/phosphatidylcholine transfer protein SFH10;
DE AltName: Full=Protein SEC FOURTEEN HOMOLOGS 10;
DE Short=AtSFH10;
GN Name=SFH10; OrderedLocusNames=At2g18180; ORFNames=F8D23.4;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY.
RX PubMed=15728190; DOI=10.1083/jcb.200412074;
RA Vincent P., Chua M., Nogue F., Fairbrother A., Mekeel H., Xu Y., Allen N.,
RA Bibikova T.N., Gilroy S., Bankaitis V.A.;
RT "A Sec14p-nodulin domain phosphatidylinositol transfer protein polarizes
RT membrane growth of Arabidopsis thaliana root hairs.";
RL J. Cell Biol. 168:801-812(2005).
RN [4]
RP REVIEW.
RX PubMed=17051233; DOI=10.1038/nchembio835;
RA Ile K.E., Schaaf G., Bankaitis V.A.;
RT "Phosphatidylinositol transfer proteins and cellular nanoreactors for lipid
RT signaling.";
RL Nat. Chem. Biol. 2:576-583(2006).
CC -!- FUNCTION: Required for transport of secretory proteins from the Golgi
CC complex. Catalyzes the transfer of phosphatidylinositol and
CC phosphatidylcholine between membranes in vitro (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SFH family. {ECO:0000305}.
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DR EMBL; AC007212; AAD31348.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC06735.1; -; Genomic_DNA.
DR PIR; C84561; C84561.
DR RefSeq; NP_179410.1; NM_127375.2.
DR AlphaFoldDB; Q9SI13; -.
DR SMR; Q9SI13; -.
DR STRING; 3702.AT2G18180.1; -.
DR PaxDb; Q9SI13; -.
DR EnsemblPlants; AT2G18180.1; AT2G18180.1; AT2G18180.
DR GeneID; 816331; -.
DR Gramene; AT2G18180.1; AT2G18180.1; AT2G18180.
DR KEGG; ath:AT2G18180; -.
DR Araport; AT2G18180; -.
DR TAIR; locus:2053114; AT2G18180.
DR eggNOG; KOG1471; Eukaryota.
DR HOGENOM; CLU_014001_11_1_1; -.
DR InParanoid; Q9SI13; -.
DR OrthoDB; 1133487at2759; -.
DR PhylomeDB; Q9SI13; -.
DR PRO; PR:Q9SI13; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9SI13; baseline and differential.
DR Genevisible; Q9SI13; AT.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; -; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011074; CRAL/TRIO_N_dom.
DR InterPro; IPR036273; CRAL/TRIO_N_dom_sf.
DR Pfam; PF00650; CRAL_TRIO; 1.
DR Pfam; PF03765; CRAL_TRIO_N; 1.
DR SMART; SM01100; CRAL_TRIO_N; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF46938; SSF46938; 1.
DR SUPFAM; SSF52087; SSF52087; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
PE 3: Inferred from homology;
KW Cell membrane; Coiled coil; Golgi apparatus; Membrane; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..558
FT /note="Phosphatidylinositol/phosphatidylcholine transfer
FT protein SFH10"
FT /id="PRO_0000423470"
FT DOMAIN 123..297
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00056"
FT COILED 464..529
FT /evidence="ECO:0000255"
SQ SEQUENCE 558 AA; 63359 MW; 9A2CC3F04BEFB5A5 CRC64;
MSLNVDLDVC VLERPNVCSF KKRSCSKLSC SLTKKRRSSK VMSVEIFEDE HDAEELKVVD
AFRQVLILDE LLPDKHDDYH MMLRFLKARK FDLEKTNQMW SDMLRWRKEF GADTVMEDFE
FKEIDEVLKY YPQGHHGVDK EGRPVYIERL GQVDSTKLMQ VTTMDRYVNY HVMEFERTFN
VKFPACSIAA KKHIDQSTTI LDVQGVGLKN FNKAARDLIT RLQKVDGDNY PETLNRMFII
NAGSGFRMLW NTVKSFLDPK TTAKIHVLGN KYQSKLLEII DASELPEFLG GSCTCADNGG
CMRSDKGPWN NPDIMKRVNN GDHICSKRSQ ADNAGENIIS QGNNSAVEEA PETDQSQPSP
CQNVVVAHPA WNIPEAHKFS LSKRDVYAIQ EACKATNESG RSPIFTGVMA FVMGVVTMIR
VTKNVPRKLT ESTIYSSPVY CDENSMNKSS MHGKKMATTT ISGEDFMAVM KRMAELEQKV
TNLSAQPATM PPEKEEMLNA AISRADFLEQ ELAATKKALD DSLTRQEDLV AYVERKKKKK
KLVRFQINAY LTNFCFGV