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SFH10_ARATH
ID   SFH10_ARATH             Reviewed;         558 AA.
AC   Q9SI13;
DT   18-SEP-2013, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=Phosphatidylinositol/phosphatidylcholine transfer protein SFH10;
DE   AltName: Full=Protein SEC FOURTEEN HOMOLOGS 10;
DE            Short=AtSFH10;
GN   Name=SFH10; OrderedLocusNames=At2g18180; ORFNames=F8D23.4;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENE FAMILY.
RX   PubMed=15728190; DOI=10.1083/jcb.200412074;
RA   Vincent P., Chua M., Nogue F., Fairbrother A., Mekeel H., Xu Y., Allen N.,
RA   Bibikova T.N., Gilroy S., Bankaitis V.A.;
RT   "A Sec14p-nodulin domain phosphatidylinositol transfer protein polarizes
RT   membrane growth of Arabidopsis thaliana root hairs.";
RL   J. Cell Biol. 168:801-812(2005).
RN   [4]
RP   REVIEW.
RX   PubMed=17051233; DOI=10.1038/nchembio835;
RA   Ile K.E., Schaaf G., Bankaitis V.A.;
RT   "Phosphatidylinositol transfer proteins and cellular nanoreactors for lipid
RT   signaling.";
RL   Nat. Chem. Biol. 2:576-583(2006).
CC   -!- FUNCTION: Required for transport of secretory proteins from the Golgi
CC       complex. Catalyzes the transfer of phosphatidylinositol and
CC       phosphatidylcholine between membranes in vitro (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SFH family. {ECO:0000305}.
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DR   EMBL; AC007212; AAD31348.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC06735.1; -; Genomic_DNA.
DR   PIR; C84561; C84561.
DR   RefSeq; NP_179410.1; NM_127375.2.
DR   AlphaFoldDB; Q9SI13; -.
DR   SMR; Q9SI13; -.
DR   STRING; 3702.AT2G18180.1; -.
DR   PaxDb; Q9SI13; -.
DR   EnsemblPlants; AT2G18180.1; AT2G18180.1; AT2G18180.
DR   GeneID; 816331; -.
DR   Gramene; AT2G18180.1; AT2G18180.1; AT2G18180.
DR   KEGG; ath:AT2G18180; -.
DR   Araport; AT2G18180; -.
DR   TAIR; locus:2053114; AT2G18180.
DR   eggNOG; KOG1471; Eukaryota.
DR   HOGENOM; CLU_014001_11_1_1; -.
DR   InParanoid; Q9SI13; -.
DR   OrthoDB; 1133487at2759; -.
DR   PhylomeDB; Q9SI13; -.
DR   PRO; PR:Q9SI13; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q9SI13; baseline and differential.
DR   Genevisible; Q9SI13; AT.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd00170; SEC14; 1.
DR   Gene3D; 3.40.525.10; -; 1.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR   InterPro; IPR011074; CRAL/TRIO_N_dom.
DR   InterPro; IPR036273; CRAL/TRIO_N_dom_sf.
DR   Pfam; PF00650; CRAL_TRIO; 1.
DR   Pfam; PF03765; CRAL_TRIO_N; 1.
DR   SMART; SM01100; CRAL_TRIO_N; 1.
DR   SMART; SM00516; SEC14; 1.
DR   SUPFAM; SSF46938; SSF46938; 1.
DR   SUPFAM; SSF52087; SSF52087; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Coiled coil; Golgi apparatus; Membrane; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..558
FT                   /note="Phosphatidylinositol/phosphatidylcholine transfer
FT                   protein SFH10"
FT                   /id="PRO_0000423470"
FT   DOMAIN          123..297
FT                   /note="CRAL-TRIO"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00056"
FT   COILED          464..529
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   558 AA;  63359 MW;  9A2CC3F04BEFB5A5 CRC64;
     MSLNVDLDVC VLERPNVCSF KKRSCSKLSC SLTKKRRSSK VMSVEIFEDE HDAEELKVVD
     AFRQVLILDE LLPDKHDDYH MMLRFLKARK FDLEKTNQMW SDMLRWRKEF GADTVMEDFE
     FKEIDEVLKY YPQGHHGVDK EGRPVYIERL GQVDSTKLMQ VTTMDRYVNY HVMEFERTFN
     VKFPACSIAA KKHIDQSTTI LDVQGVGLKN FNKAARDLIT RLQKVDGDNY PETLNRMFII
     NAGSGFRMLW NTVKSFLDPK TTAKIHVLGN KYQSKLLEII DASELPEFLG GSCTCADNGG
     CMRSDKGPWN NPDIMKRVNN GDHICSKRSQ ADNAGENIIS QGNNSAVEEA PETDQSQPSP
     CQNVVVAHPA WNIPEAHKFS LSKRDVYAIQ EACKATNESG RSPIFTGVMA FVMGVVTMIR
     VTKNVPRKLT ESTIYSSPVY CDENSMNKSS MHGKKMATTT ISGEDFMAVM KRMAELEQKV
     TNLSAQPATM PPEKEEMLNA AISRADFLEQ ELAATKKALD DSLTRQEDLV AYVERKKKKK
     KLVRFQINAY LTNFCFGV
 
 
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