ID   SFH14_ARATH             Reviewed;         577 AA.
AC   F4K6D3; Q0WVM8; Q9FKT2;
DT   18-SEP-2013, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Phosphatidylinositol/phosphatidylcholine transfer protein SFH14;
DE   AltName: Full=Protein SEC FOURTEEN HOMOLOGS 14;
DE            Short=AtSFH14;
GN   Name=SFH14; OrderedLocusNames=At5g56160; ORFNames=MDA7.22;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=9679202; DOI=10.1093/dnares/5.2.131;
RA   Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence
RT   features of the regions of 1,381,565 bp covered by twenty one physically
RT   assigned P1 and TAC clones.";
RL   DNA Res. 5:131-145(1998).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   GENE FAMILY.
RX   PubMed=15728190; DOI=10.1083/jcb.200412074;
RA   Vincent P., Chua M., Nogue F., Fairbrother A., Mekeel H., Xu Y., Allen N.,
RA   Bibikova T.N., Gilroy S., Bankaitis V.A.;
RT   "A Sec14p-nodulin domain phosphatidylinositol transfer protein polarizes
RT   membrane growth of Arabidopsis thaliana root hairs.";
RL   J. Cell Biol. 168:801-812(2005).
RN   [5]
RP   REVIEW.
RX   PubMed=17051233; DOI=10.1038/nchembio835;
RA   Ile K.E., Schaaf G., Bankaitis V.A.;
RT   "Phosphatidylinositol transfer proteins and cellular nanoreactors for lipid
RT   signaling.";
RL   Nat. Chem. Biol. 2:576-583(2006).
CC   -!- FUNCTION: Required for transport of secretory proteins from the Golgi
CC       complex. Catalyzes the transfer of phosphatidylinositol and
CC       phosphatidylcholine between membranes in vitro (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SFH family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB09298.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AB011476; BAB09298.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002688; AED96728.1; -; Genomic_DNA.
DR   EMBL; CP002688; ANM69494.1; -; Genomic_DNA.
DR   EMBL; AK226714; BAE98820.1; -; mRNA.
DR   RefSeq; NP_001331164.1; NM_001345180.1.
DR   RefSeq; NP_200427.3; NM_124998.4.
DR   AlphaFoldDB; F4K6D3; -.
DR   SMR; F4K6D3; -.
DR   BioGRID; 20959; 1.
DR   STRING; 3702.AT5G56160.1; -.
DR   PaxDb; F4K6D3; -.
DR   PRIDE; F4K6D3; -.
DR   ProteomicsDB; 234554; -.
DR   EnsemblPlants; AT5G56160.1; AT5G56160.1; AT5G56160.
DR   EnsemblPlants; AT5G56160.3; AT5G56160.3; AT5G56160.
DR   GeneID; 835715; -.
DR   Gramene; AT5G56160.1; AT5G56160.1; AT5G56160.
DR   Gramene; AT5G56160.3; AT5G56160.3; AT5G56160.
DR   KEGG; ath:AT5G56160; -.
DR   Araport; AT5G56160; -.
DR   TAIR; locus:2161765; AT5G56160.
DR   eggNOG; KOG1471; Eukaryota.
DR   HOGENOM; CLU_014001_11_0_1; -.
DR   InParanoid; F4K6D3; -.
DR   OMA; RIIHDFN; -.
DR   OrthoDB; 1133487at2759; -.
DR   PRO; PR:F4K6D3; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; F4K6D3; baseline and differential.
DR   Genevisible; F4K6D3; AT.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd00170; SEC14; 1.
DR   Gene3D; 3.40.525.10; -; 1.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR   InterPro; IPR036273; CRAL/TRIO_N_dom_sf.
DR   Pfam; PF00650; CRAL_TRIO; 1.
DR   SMART; SM00516; SEC14; 1.
DR   SUPFAM; SSF46938; SSF46938; 1.
DR   SUPFAM; SSF52087; SSF52087; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Coiled coil; Golgi apparatus; Membrane; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..577
FT                   /note="Phosphatidylinositol/phosphatidylcholine transfer
FT                   protein SFH14"
FT                   /id="PRO_0000423474"
FT   DOMAIN          136..311
FT                   /note="CRAL-TRIO"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00056"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          364..383
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          523..550
FT                   /evidence="ECO:0000255"
FT   CONFLICT        97
FT                   /note="R -> S (in Ref. 3; BAE98820)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        113
FT                   /note="W -> R (in Ref. 3; BAE98820)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   577 AA;  66258 MW;  6A3FBEE1339F7FAE CRC64;
     MSGREQTGEK LSDSEYIEEE PRRSRIGNLK KKAFSCSTKL THPLKMRKGK RKIDFQIPLI
     EDVRDEKEEK LVSKLRQQLL QKDLLPPVHD DYHMLLRFLK TMEFKIEKTV TAWEEMLKWR
     KEFGTDRIIQ DFNFKELDEV TRHYPQGYHG VDKDGRPIYI ERLGKAHPGK LMEVTTIERY
     LKYHVQEFER TLQEKLPACS VAAKRRVTTT TTILDVEGLG MKNFTPTAAN LLATIAKVDC
     NYYPETLHRM FIVNAGIGFR SFLWPAAQKL LDPMTIAKIQ VLEPRSLSKL LEAIDSSQLP
     EFLGGLCKCP NEGGCLRSNK GPWNDPEIVE LVHHMEVNNV PQTTTAPLHV RDYDSTTCTI
     SPKETLKEEP EPEEYYSSTG SRSSMHTCIV PPLSDKASTS DGDKFITTVE SIESAQSQLL
     DADTENTFAN TSVREGGQIL RFGALREKIN SENIFHLVKI LLVFPLKLFV LFGFLLPGYW
     QRQNTVVVPD SSTNNKVLEC FDRLKKMEKE FTEISRKQVK IPEANEKLLA ESLERIKSLE
     LDLDKTKSVL HITLTKQLQI TEQLESQDEE RRKGCCF