ID   SFH1_ASHGO              Reviewed;         383 AA.
AC   Q754R8;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Chromatin structure-remodeling complex subunit SFH1;
DE   AltName: Full=RSC complex subunit SFH1;
DE   AltName: Full=SNF5 homolog 1;
GN   Name=SFH1; OrderedLocusNames=AFR004W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Part of the chromatin structure-remodeling complex (RSC)
CC       which is involved in transcription regulation and nucleosome
CC       positioning. RSC is responsible for the transfer of a histone octamer
CC       from a nucleosome core particle to naked DNA. The reaction requires ATP
CC       and involves an activated RSC-nucleosome intermediate. Remodeling
CC       reaction also involves DNA translocation, DNA twist and conformational
CC       change. As a reconfigurer of centromeric and flanking nucleosomes, RSC
CC       complex is required both for proper kinetochore function in chromosome
CC       segregation and, via a PKC1-dependent signaling pathway, for
CC       organization of the cellular cytoskeleton. This subunit is essential
CC       for mitotic growth and required for cell cycle progression (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9USM3}.
CC   -!- SIMILARITY: Belongs to the SNF5 family. {ECO:0000305}.
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DR   EMBL; AE016819; AAS53375.1; -; Genomic_DNA.
DR   RefSeq; NP_985551.1; NM_210905.1.
DR   AlphaFoldDB; Q754R8; -.
DR   SMR; Q754R8; -.
DR   STRING; 33169.AAS53375; -.
DR   EnsemblFungi; AAS53375; AAS53375; AGOS_AFR004W.
DR   GeneID; 4621790; -.
DR   KEGG; ago:AGOS_AFR004W; -.
DR   eggNOG; KOG1649; Eukaryota.
DR   HOGENOM; CLU_014421_4_0_1; -.
DR   InParanoid; Q754R8; -.
DR   OMA; NFHNRIR; -.
DR   Proteomes; UP000000591; Chromosome VI.
DR   GO; GO:0000228; C:nuclear chromosome; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0016586; C:RSC-type complex; IBA:GO_Central.
DR   GO; GO:0003712; F:transcription coregulator activity; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR017393; Sfh1/SNF5.
DR   InterPro; IPR006939; SNF5.
DR   Pfam; PF04855; SNF5; 2.
DR   PIRSF; PIRSF038126; SWI_SNF; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Chromatin regulator; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..383
FT                   /note="Chromatin structure-remodeling complex subunit SFH1"
FT                   /id="PRO_0000205957"
FT   REGION          61..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   383 AA;  43707 MW;  48F084B9F217664B CRC64;
     MSQLLPQAYL TNFHNRIRNE DVPLFITAAP TRNHKRAKVV NYSEYDNDLL LDDFIEQDQN
     DDDEKVHSDN GKGEGEEVGH EDAVASNNNL PDLEQQDDPT GILRYPRIRE TFLQSKIAVR
     YEQVLEAGVG GSGEAVGIAE DEGAGAYSSS SQPVVIPIRL NLEHNGHKII DFFTWNLNDH
     SLTLEQFAQI YCQDLDFAHN LSLQNQIVAA INDQLQEYET LASVVVPDLH VIINLTCNLD
     SKLYEDNFEW NLNDQTLSPE QFAELVVQDL GLTREFMPAI AHALYESILK IKKDWLEGHL
     NPEHVANGAA FGCLSGIRLD IDTLGSNWCP KVEVLSQWEI EKREIEKERN MRRLKRESAK
     VDDRLARRRG KRRMDDLETT MRI