ID   SFH1_CANGA              Reviewed;         403 AA.
AC   Q6FTV3;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Chromatin structure-remodeling complex subunit SFH1;
DE   AltName: Full=RSC complex subunit SFH1;
DE   AltName: Full=SNF5 homolog 1;
GN   Name=SFH1; OrderedLocusNames=CAGL0F08569g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Part of the chromatin structure-remodeling complex (RSC)
CC       which is involved in transcription regulation and nucleosome
CC       positioning. RSC is responsible for the transfer of a histone octamer
CC       from a nucleosome core particle to naked DNA. The reaction requires ATP
CC       and involves an activated RSC-nucleosome intermediate. Remodeling
CC       reaction also involves DNA translocation, DNA twist and conformational
CC       change. As a reconfigurer of centromeric and flanking nucleosomes, RSC
CC       complex is required both for proper kinetochore function in chromosome
CC       segregation and, via a PKC1-dependent signaling pathway, for
CC       organization of the cellular cytoskeleton. This subunit is essential
CC       for mitotic growth and required for cell cycle progression (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9USM3}.
CC   -!- SIMILARITY: Belongs to the SNF5 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR380952; CAG59265.1; -; Genomic_DNA.
DR   RefSeq; XP_446341.1; XM_446341.1.
DR   AlphaFoldDB; Q6FTV3; -.
DR   SMR; Q6FTV3; -.
DR   STRING; 5478.XP_446341.1; -.
DR   EnsemblFungi; CAG59265; CAG59265; CAGL0F08569g.
DR   GeneID; 2887854; -.
DR   KEGG; cgr:CAGL0F08569g; -.
DR   CGD; CAL0129348; CAGL0F08569g.
DR   VEuPathDB; FungiDB:CAGL0F08569g; -.
DR   eggNOG; KOG1649; Eukaryota.
DR   HOGENOM; CLU_014421_4_0_1; -.
DR   InParanoid; Q6FTV3; -.
DR   OMA; NFHNRIR; -.
DR   Proteomes; UP000002428; Chromosome F.
DR   GO; GO:0000228; C:nuclear chromosome; IEA:InterPro.
DR   GO; GO:0070603; C:SWI/SNF superfamily-type complex; IEA:UniProt.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR   InterPro; IPR017393; Sfh1/SNF5.
DR   InterPro; IPR006939; SNF5.
DR   Pfam; PF04855; SNF5; 2.
DR   PIRSF; PIRSF038126; SWI_SNF; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Chromatin regulator; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..403
FT                   /note="Chromatin structure-remodeling complex subunit SFH1"
FT                   /id="PRO_0000205958"
FT   REGION          58..115
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        99..113
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   403 AA;  44819 MW;  64A172A3F548B108 CRC64;
     MSNRAVPQGY LANLQFRIRS DNLPLLSTVQ PSRGHKRGGR AVNYAEFDNE LLEDFSNFPT
     FDIDSDSNDE EQSSASAGND DPQANANGGE AAGVNGQGSG DGGSANTGAG RHGKSQLTAE
     MEKNYKTGVP DLNEQKDSLN VLRYQKIRES FQHGKIAVPY RLYVPPELST GQQEAILIPI
     TLNVEHGNNT ISDAFVWNVN DTSISVEDFV TTYCNDLGLY GNVSLHSQIV SSINEQIQEL
     ENVASLVIPD LEVVVNLTCT IQGKFFEDYF QWNLSDKSLS PEKFALIIVA DLGLAREFAP
     GIAHSLHEYL LHVKKEWAEG SLHQDTVPNE AAFGYLAGVR LNIDDLGAKW APKVEYLTQE
     EIQKREIEKE RNMRRLKRES DRMGGGARRG RRRLDDLELT MKM