ID   SFH1_KLULA              Reviewed;         442 AA.
AC   Q6CSR7;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Chromatin structure-remodeling complex subunit SFH1;
DE   AltName: Full=RSC complex subunit SFH1;
DE   AltName: Full=SNF5 homolog 1;
GN   Name=SFH1; OrderedLocusNames=KLLA0C18447g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Part of the chromatin structure-remodeling complex (RSC)
CC       which is involved in transcription regulation and nucleosome
CC       positioning. RSC is responsible for the transfer of a histone octamer
CC       from a nucleosome core particle to naked DNA. The reaction requires ATP
CC       and involves an activated RSC-nucleosome intermediate. Remodeling
CC       reaction also involves DNA translocation, DNA twist and conformational
CC       change. As a reconfigurer of centromeric and flanking nucleosomes, RSC
CC       complex is required both for proper kinetochore function in chromosome
CC       segregation and, via a PKC1-dependent signaling pathway, for
CC       organization of the cellular cytoskeleton. This subunit is essential
CC       for mitotic growth and required for cell cycle progression (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9USM3}.
CC   -!- SIMILARITY: Belongs to the SNF5 family. {ECO:0000305}.
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DR   EMBL; CR382123; CAH01873.1; -; Genomic_DNA.
DR   RefSeq; XP_453022.1; XM_453022.1.
DR   AlphaFoldDB; Q6CSR7; -.
DR   SMR; Q6CSR7; -.
DR   STRING; 28985.XP_453022.1; -.
DR   EnsemblFungi; CAH01873; CAH01873; KLLA0_C18447g.
DR   GeneID; 2892289; -.
DR   KEGG; kla:KLLA0_C18447g; -.
DR   eggNOG; KOG1649; Eukaryota.
DR   HOGENOM; CLU_014421_4_0_1; -.
DR   InParanoid; Q6CSR7; -.
DR   OMA; NFHNRIR; -.
DR   Proteomes; UP000000598; Chromosome C.
DR   GO; GO:0000228; C:nuclear chromosome; IEA:InterPro.
DR   GO; GO:0016586; C:RSC-type complex; IEA:EnsemblFungi.
DR   GO; GO:0031055; P:chromatin remodeling at centromere; IEA:EnsemblFungi.
DR   GO; GO:0007059; P:chromosome segregation; IEA:EnsemblFungi.
DR   GO; GO:0006302; P:double-strand break repair; IEA:EnsemblFungi.
DR   GO; GO:0000086; P:G2/M transition of mitotic cell cycle; IEA:EnsemblFungi.
DR   GO; GO:0006337; P:nucleosome disassembly; IEA:EnsemblFungi.
DR   GO; GO:0033262; P:regulation of nuclear cell cycle DNA replication; IEA:EnsemblFungi.
DR   GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR   InterPro; IPR017393; Sfh1/SNF5.
DR   InterPro; IPR006939; SNF5.
DR   Pfam; PF04855; SNF5; 2.
DR   PIRSF; PIRSF038126; SWI_SNF; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Chromatin regulator; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..442
FT                   /note="Chromatin structure-remodeling complex subunit SFH1"
FT                   /id="PRO_0000205959"
FT   REGION          54..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          102..148
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          415..442
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        133..148
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   442 AA;  49078 MW;  FF96661A50E11587 CRC64;
     MSLVPQAYLS NFHNRVKNED VPLFTAAQLS RNKRGKQVNY AEFDTDLLDE FIDKNDEDDL
     EDDVDDSDGR RRGGDYYDQV DGSDGGAAAA AATAAAAAGL GEDGGIGEGT PGSGDPGAVT
     GGTPAADTGP DGTNDGTAGT SNPSSELDRI KLNDLPDLES QDDSATPLAL LKYPRIRETF
     VQSRIAISYK DLLGDSIQDP QQVDIESPIM VPIRLNVEFS GHKLADFFMW NLNDHSMTPE
     QFATILCQDL DFPVLSNPNN SPYTQIISMI NEQLQEYETL ASLQVPDLHV IINLTANLDS
     KLYDDTFEWN LNDDSLCPEQ FAELVVQDLG LQREFVPAIA HSLHESLLKV KKDWLEGNLN
     LAHVENKAAF GYTSGIRLDI DTLGASWFPK VEVLSQWEIE KREIEKERNM RRLKRESAKV
     DDGRSRRRGK RRMDDLETTL RI