ID   SFH2_ARATH              Reviewed;         554 AA.
AC   F4JVA9; Q9T027;
DT   18-SEP-2013, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Phosphatidylinositol/phosphatidylcholine transfer protein SFH2;
DE   AltName: Full=Protein SEC FOURTEEN HOMOLOGS 2;
DE            Short=AtSFH2;
GN   Name=SFH2; OrderedLocusNames=At4g39180; ORFNames=T22F8.80;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617198; DOI=10.1038/47134;
RA   Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA   Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA   Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA   de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA   Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA   Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA   Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA   Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA   Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA   Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA   Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA   Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA   Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA   Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA   Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA   Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA   Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA   Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA   Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA   Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA   Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA   Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA   Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA   Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA   Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA   Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA   de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA   Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA   Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA   Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA   Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA   Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA   Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA   Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA   Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA   Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA   O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA   Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA   Martienssen R., McCombie W.R.;
RT   "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL   Nature 402:769-777(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENE FAMILY, AND FUNCTION.
RX   PubMed=15728190; DOI=10.1083/jcb.200412074;
RA   Vincent P., Chua M., Nogue F., Fairbrother A., Mekeel H., Xu Y., Allen N.,
RA   Bibikova T.N., Gilroy S., Bankaitis V.A.;
RT   "A Sec14p-nodulin domain phosphatidylinositol transfer protein polarizes
RT   membrane growth of Arabidopsis thaliana root hairs.";
RL   J. Cell Biol. 168:801-812(2005).
RN   [4]
RP   REVIEW.
RX   PubMed=17051233; DOI=10.1038/nchembio835;
RA   Ile K.E., Schaaf G., Bankaitis V.A.;
RT   "Phosphatidylinositol transfer proteins and cellular nanoreactors for lipid
RT   signaling.";
RL   Nat. Chem. Biol. 2:576-583(2006).
CC   -!- FUNCTION: Required for transport of secretory proteins from the Golgi
CC       complex (By similarity). Catalyzes the transfer of phosphatidylinositol
CC       and phosphatidylcholine between membranes in vitro. {ECO:0000250,
CC       ECO:0000269|PubMed:15728190}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=1;
CC         Comment=A number of isoforms are produced. According to EST
CC         sequences.;
CC       Name=1;
CC         IsoId=F4JVA9-1; Sequence=Displayed;
CC   -!- SIMILARITY: Belongs to the SFH family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAB43633.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=CAB80581.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AL050351; CAB43633.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AL161594; CAB80581.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002687; AEE87033.1; -; Genomic_DNA.
DR   PIR; T08566; T08566.
DR   RefSeq; NP_195629.2; NM_120078.2. [F4JVA9-1]
DR   AlphaFoldDB; F4JVA9; -.
DR   SMR; F4JVA9; -.
DR   STRING; 3702.AT4G39180.1; -.
DR   PaxDb; F4JVA9; -.
DR   PRIDE; F4JVA9; -.
DR   ProteomicsDB; 234517; -. [F4JVA9-1]
DR   EnsemblPlants; AT4G39180.1; AT4G39180.1; AT4G39180. [F4JVA9-1]
DR   GeneID; 830073; -.
DR   Gramene; AT4G39180.1; AT4G39180.1; AT4G39180. [F4JVA9-1]
DR   KEGG; ath:AT4G39180; -.
DR   Araport; AT4G39180; -.
DR   TAIR; locus:2136303; AT4G39180.
DR   eggNOG; KOG1471; Eukaryota.
DR   InParanoid; F4JVA9; -.
DR   OMA; ETKKKCE; -.
DR   OrthoDB; 1133487at2759; -.
DR   PRO; PR:F4JVA9; -.
DR   Proteomes; UP000006548; Chromosome 4.
DR   ExpressionAtlas; F4JVA9; baseline and differential.
DR   Genevisible; F4JVA9; AT.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006656; P:phosphatidylcholine biosynthetic process; TAS:TAIR.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd00170; SEC14; 1.
DR   Gene3D; 3.40.525.10; -; 1.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR   InterPro; IPR011074; CRAL/TRIO_N_dom.
DR   InterPro; IPR036273; CRAL/TRIO_N_dom_sf.
DR   Pfam; PF00650; CRAL_TRIO; 1.
DR   Pfam; PF03765; CRAL_TRIO_N; 1.
DR   SMART; SM01100; CRAL_TRIO_N; 1.
DR   SMART; SM00516; SEC14; 1.
DR   SUPFAM; SSF46938; SSF46938; 1.
DR   SUPFAM; SSF52087; SSF52087; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Cell membrane; Coiled coil; Golgi apparatus;
KW   Membrane; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..554
FT                   /note="Phosphatidylinositol/phosphatidylcholine transfer
FT                   protein SFH2"
FT                   /id="PRO_0000423462"
FT   DOMAIN          138..312
FT                   /note="CRAL-TRIO"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00056"
FT   COILED          472..534
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   554 AA;  63860 MW;  980F9629C423C170 CRC64;
     MADTMVAHMD RHNKIDVEIS EDDKRLTKLC SLKKKAINAT NKFKHSMTKK GRRHSRVACV
     SIVDEIDTEE LQAVDAFRQA LILDELLPSK HDDHHMMLRF LRARKFDLEK AKQMWSDMLN
     WRKEYGADTI MEDFDFKEIE EVVKYYPQGY HGVDKEGRPI YIERLGQVDA TKLMKVTTID
     RYVKYHVKEF EKTFNVKFPA CSIAAKRHID QSTTILDVQG VGLSNFNKAA KDLLQSIQKI
     DNDNYPETLN RMFIINAGCG FRLLWNTVKS FLDPKTTAKI HVLGNKYQTK LLEIIDANEL
     PEFLGGKCTC ADKGGCMRSD KGPWNDPEIF KLVQNGEGRC LRRSLSGIEE KTIFEYNNET
     KKKCEPEETH KQSAAEMEKK FIDTNVDAAA AADWPTKLNK AEKNPTDLKD VYSAVNPLER
     KGYLYGSVMA LLMGIVGVMR LTKNMPRRLT EANVYSREGS AVYQDGVTVM SKQEYIAMVK
     KITDLEEKCK SMEAQAAFYM EREKTLDAAL RRIDQLELQL SETNKALDET MTRQHEIMAF
     IEKKKKKKRK FLLF