SFH3_ARATH
ID SFH3_ARATH Reviewed; 548 AA.
AC Q93ZE9; Q9SIK5;
DT 18-SEP-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Phosphatidylinositol/phosphatidylcholine transfer protein SFH3;
DE AltName: Full=Protein SEC FOURTEEN HOMOLOGS 3;
DE Short=AtSFH3;
GN Name=SFH3; OrderedLocusNames=At2g21540; ORFNames=F2G1.19, F3K23.30;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY.
RX PubMed=15728190; DOI=10.1083/jcb.200412074;
RA Vincent P., Chua M., Nogue F., Fairbrother A., Mekeel H., Xu Y., Allen N.,
RA Bibikova T.N., Gilroy S., Bankaitis V.A.;
RT "A Sec14p-nodulin domain phosphatidylinositol transfer protein polarizes
RT membrane growth of Arabidopsis thaliana root hairs.";
RL J. Cell Biol. 168:801-812(2005).
RN [6]
RP REVIEW.
RX PubMed=17051233; DOI=10.1038/nchembio835;
RA Ile K.E., Schaaf G., Bankaitis V.A.;
RT "Phosphatidylinositol transfer proteins and cellular nanoreactors for lipid
RT signaling.";
RL Nat. Chem. Biol. 2:576-583(2006).
RN [7]
RP TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND FUNCTION.
RX PubMed=16697077; DOI=10.1016/j.jplph.2006.03.014;
RA Mo P., Zhu Y., Liu X., Zhang A., Yan C., Wang D.;
RT "Identification of two phosphatidylinositol/phosphatidylcholine transfer
RT protein genes that are predominately transcribed in the flowers of
RT Arabidopsis thaliana.";
RL J. Plant Physiol. 164:478-486(2007).
CC -!- FUNCTION: Required for transport of secretory proteins from the Golgi
CC complex (By similarity). Catalyzes the transfer of phosphatidylinositol
CC and phosphatidylcholine between membranes in vitro. {ECO:0000250,
CC ECO:0000269|PubMed:16697077}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q93ZE9-1; Sequence=Displayed;
CC -!- TISSUE SPECIFICITY: Predominantly expressed in flowers but also
CC slightly detected in stems and immature siliques.
CC {ECO:0000269|PubMed:16697077}.
CC -!- DEVELOPMENTAL STAGE: First detected in the stigma papillae of the
CC flowers at stage 11, and then in the pollen grains before and after
CC fertilization. {ECO:0000269|PubMed:16697077}.
CC -!- SIMILARITY: Belongs to the SFH family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD23650.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC006841; AAM15309.1; -; Genomic_DNA.
DR EMBL; AC007119; AAD23650.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC07192.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC07193.1; -; Genomic_DNA.
DR EMBL; CP002685; ANM61245.1; -; Genomic_DNA.
DR EMBL; CP002685; ANM61247.1; -; Genomic_DNA.
DR EMBL; AY057587; AAL14382.1; -; mRNA.
DR EMBL; AK176420; BAD44183.1; -; mRNA.
DR PIR; E84602; E84602.
DR RefSeq; NP_001031389.1; NM_001036312.2. [Q93ZE9-1]
DR RefSeq; NP_001318263.1; NM_001335761.1. [Q93ZE9-1]
DR RefSeq; NP_001323475.1; NM_001335763.1. [Q93ZE9-1]
DR RefSeq; NP_565514.1; NM_127726.2. [Q93ZE9-1]
DR AlphaFoldDB; Q93ZE9; -.
DR SMR; Q93ZE9; -.
DR STRING; 3702.AT2G21540.1; -.
DR PaxDb; Q93ZE9; -.
DR PRIDE; Q93ZE9; -.
DR ProteomicsDB; 232650; -. [Q93ZE9-1]
DR EnsemblPlants; AT2G21540.1; AT2G21540.1; AT2G21540. [Q93ZE9-1]
DR EnsemblPlants; AT2G21540.2; AT2G21540.2; AT2G21540. [Q93ZE9-1]
DR EnsemblPlants; AT2G21540.4; AT2G21540.4; AT2G21540. [Q93ZE9-1]
DR EnsemblPlants; AT2G21540.6; AT2G21540.6; AT2G21540. [Q93ZE9-1]
DR GeneID; 816693; -.
DR Gramene; AT2G21540.1; AT2G21540.1; AT2G21540. [Q93ZE9-1]
DR Gramene; AT2G21540.2; AT2G21540.2; AT2G21540. [Q93ZE9-1]
DR Gramene; AT2G21540.4; AT2G21540.4; AT2G21540. [Q93ZE9-1]
DR Gramene; AT2G21540.6; AT2G21540.6; AT2G21540. [Q93ZE9-1]
DR KEGG; ath:AT2G21540; -.
DR Araport; AT2G21540; -.
DR TAIR; locus:2049319; AT2G21540.
DR eggNOG; KOG1471; Eukaryota.
DR InParanoid; Q93ZE9; -.
DR OMA; HMALMKR; -.
DR OrthoDB; 1133487at2759; -.
DR PhylomeDB; Q93ZE9; -.
DR PRO; PR:Q93ZE9; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q93ZE9; baseline and differential.
DR Genevisible; Q93ZE9; AT.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009908; P:flower development; IDA:TAIR.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; -; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011074; CRAL/TRIO_N_dom.
DR InterPro; IPR036273; CRAL/TRIO_N_dom_sf.
DR Pfam; PF00650; CRAL_TRIO; 1.
DR Pfam; PF03765; CRAL_TRIO_N; 1.
DR SMART; SM01100; CRAL_TRIO_N; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF46938; SSF46938; 1.
DR SUPFAM; SSF52087; SSF52087; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Coiled coil; Golgi apparatus;
KW Membrane; Protein transport; Reference proteome; Transport.
FT CHAIN 1..548
FT /note="Phosphatidylinositol/phosphatidylcholine transfer
FT protein SFH3"
FT /id="PRO_0000423463"
FT DOMAIN 137..311
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00056"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 465..530
FT /evidence="ECO:0000255"
SQ SEQUENCE 548 AA; 62832 MW; 4AD38E72B779BA33 CRC64;
MTDTMSAHMD RHNKLDYDGS EDEKKTKLCS LKKKAINASN KFKHSFTKRT RRNSRVMSVS
IVDDIDLEEL QAVDAFRQAL ILDELLPSKH DDHHMMLRFL RARKFDLEKA KQMWTDMIHW
RKEFGVDTIM EDFDFKEIDE VLKYYPQGYH GVDKDGRPVY IERLGQVDAT KLMQVTTIDR
YVKYHVREFE KTFNIKLPAC SIAAKKHIDQ STTILDVQGV GLKSFSKAAR DLLQRIQKID
SDNYPETLNR MFIINAGSGF RLLWSTVKSF LDPKTTAKIH VLGNKYQSKL LEIIDSNELP
EFLGGNCTCA DKGGCMRSDK GPWNDPDIFK MVQNGEGKCP RKTLSNIEEK TISVDENTTM
KSDSFAKNKF DAENTKFIPM IDKTVNASTW PTNLHKSNYP EPEDLYSAVK PSQRRGGEGY
LFGGVMSLVM GLMTVVRLTK NMPRKLTEAA IYGGEVDKAE TTMVSNQEYM SMVKRMAELE
EKCRSLDNQP AAFSPEKEQI LTAALSRVDE LELQLAQTKK TLEETMATQH VIMAYIDKKK
KKKKFFGF
