SFH6_ARATH
ID SFH6_ARATH Reviewed; 614 AA.
AC F4JVA6; Q94C34; Q9T026;
DT 18-SEP-2013, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 63.
DE RecName: Full=Phosphatidylinositol/phosphatidylcholine transfer protein SFH6;
DE AltName: Full=Protein SEC FOURTEEN HOMOLOGS 6;
DE Short=AtSFH6;
GN Name=SFH6; OrderedLocusNames=At4g39170; ORFNames=T22F8.70;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY.
RX PubMed=15728190; DOI=10.1083/jcb.200412074;
RA Vincent P., Chua M., Nogue F., Fairbrother A., Mekeel H., Xu Y., Allen N.,
RA Bibikova T.N., Gilroy S., Bankaitis V.A.;
RT "A Sec14p-nodulin domain phosphatidylinositol transfer protein polarizes
RT membrane growth of Arabidopsis thaliana root hairs.";
RL J. Cell Biol. 168:801-812(2005).
RN [5]
RP REVIEW.
RX PubMed=17051233; DOI=10.1038/nchembio835;
RA Ile K.E., Schaaf G., Bankaitis V.A.;
RT "Phosphatidylinositol transfer proteins and cellular nanoreactors for lipid
RT signaling.";
RL Nat. Chem. Biol. 2:576-583(2006).
CC -!- FUNCTION: Required for transport of secretory proteins from the Golgi
CC complex. Catalyzes the transfer of phosphatidylinositol and
CC phosphatidylcholine between membranes in vitro (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=F4JVA6-1; Sequence=Displayed;
CC -!- SIMILARITY: Belongs to the SFH family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK59767.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AAM91428.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAB43632.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB80580.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL050351; CAB43632.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161594; CAB80580.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE87031.1; -; Genomic_DNA.
DR EMBL; AY037182; AAK59767.1; ALT_FRAME; mRNA.
DR EMBL; AY133598; AAM91428.1; ALT_FRAME; mRNA.
DR PIR; T08565; T08565.
DR RefSeq; NP_568054.1; NM_120077.4. [F4JVA6-1]
DR AlphaFoldDB; F4JVA6; -.
DR SMR; F4JVA6; -.
DR STRING; 3702.AT4G39170.1; -.
DR iPTMnet; F4JVA6; -.
DR PaxDb; F4JVA6; -.
DR PRIDE; F4JVA6; -.
DR ProteomicsDB; 232677; -. [F4JVA6-1]
DR EnsemblPlants; AT4G39170.1; AT4G39170.1; AT4G39170. [F4JVA6-1]
DR GeneID; 830072; -.
DR Gramene; AT4G39170.1; AT4G39170.1; AT4G39170. [F4JVA6-1]
DR KEGG; ath:AT4G39170; -.
DR Araport; AT4G39170; -.
DR TAIR; locus:2136288; AT4G39170.
DR eggNOG; KOG1471; Eukaryota.
DR InParanoid; F4JVA6; -.
DR OMA; VQEFTFD; -.
DR PRO; PR:F4JVA6; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; F4JVA6; baseline and differential.
DR Genevisible; F4JVA6; AT.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; -; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011074; CRAL/TRIO_N_dom.
DR InterPro; IPR036273; CRAL/TRIO_N_dom_sf.
DR Pfam; PF00650; CRAL_TRIO; 1.
DR Pfam; PF03765; CRAL_TRIO_N; 1.
DR SMART; SM01100; CRAL_TRIO_N; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF46938; SSF46938; 1.
DR SUPFAM; SSF52087; SSF52087; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Coiled coil; Golgi apparatus;
KW Membrane; Protein transport; Reference proteome; Transport.
FT CHAIN 1..614
FT /note="Phosphatidylinositol/phosphatidylcholine transfer
FT protein SFH6"
FT /id="PRO_0000423466"
FT DOMAIN 150..324
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00056"
FT REGION 19..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 519..576
FT /evidence="ECO:0000255"
SQ SEQUENCE 614 AA; 69603 MW; 3B3843BA76BD0C5A CRC64;
MSGPVDRFAI PCFEGILSSD EKKERKSDFE NSEDERRTRI GSLKKKAINA STKFKHSLKK
KRRKSDVRVS SVSIEDVRDV EELQAVDEFR QALVMEELLP HKHDDYHMML RFLKARKFDI
EKAKHMWADM IQWRKEFGTD TIIQDFQFEE IDEVLKYYPH GYHSVDKEGR PVYIERLGKV
DPNKLMQVTT LDRYIRYHVK EFERSFMLKF PACTIAAKKY IDSSTTILDV QGVGLKNFTK
SARELITRLQ KIDGDNYPET LHQMFIINAG PGFRLLWSTV KSFLDPKTTS KIHVLGCKYQ
SKLLEIIDSS ELPEFLGGAC TCADQGGCML SDKGPWKNPE IVKMVLHGGA HRAKQVVKVL
NSDGKVIAYA KPSYPWIKGS DTSTAESGSE AEDIVVSPKA VKSYSHLRLT PVREEAKVGS
GETSFAGSFA GYDEYVPMVD KAVDATWKVK PTAINRAPSK GAHMPPNVPK DHESFSARVL
VTFMAFVMAI LTFFRTVSNR VVTKQLPPPP SQPQIEGSAA AEEADLLNSV LKKLTELEEK
IGALQSKPSE MPYEKEELLN AAVCRVDALE AELIATKKAL YEALMRQEEL LAYIDRQEAA
QHQKKNKRKQ MFCF
