ID   SFH7_ARATH              Reviewed;         547 AA.
AC   Q9SIW3; Q943Z9;
DT   18-SEP-2013, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 2.
DT   25-MAY-2022, entry version 116.
DE   RecName: Full=Phosphatidylinositol/phosphatidylcholine transfer protein SFH7;
DE   AltName: Full=Protein SEC FOURTEEN HOMOLOGS 7;
DE            Short=AtSFH7;
GN   Name=SFH7; OrderedLocusNames=At2g16380; ORFNames=F16F14.12;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   GENE FAMILY.
RX   PubMed=15728190; DOI=10.1083/jcb.200412074;
RA   Vincent P., Chua M., Nogue F., Fairbrother A., Mekeel H., Xu Y., Allen N.,
RA   Bibikova T.N., Gilroy S., Bankaitis V.A.;
RT   "A Sec14p-nodulin domain phosphatidylinositol transfer protein polarizes
RT   membrane growth of Arabidopsis thaliana root hairs.";
RL   J. Cell Biol. 168:801-812(2005).
RN   [5]
RP   REVIEW.
RX   PubMed=17051233; DOI=10.1038/nchembio835;
RA   Ile K.E., Schaaf G., Bankaitis V.A.;
RT   "Phosphatidylinositol transfer proteins and cellular nanoreactors for lipid
RT   signaling.";
RL   Nat. Chem. Biol. 2:576-583(2006).
CC   -!- FUNCTION: Required for transport of secretory proteins from the Golgi
CC       complex. Catalyzes the transfer of phosphatidylinositol and
CC       phosphatidylcholine between membranes in vitro (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SFH family. {ECO:0000305}.
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DR   EMBL; AC007047; AAD22301.2; -; Genomic_DNA.
DR   EMBL; CP002685; AEC06490.1; -; Genomic_DNA.
DR   EMBL; CP002685; ANM61229.1; -; Genomic_DNA.
DR   EMBL; AF439836; AAL27507.1; -; mRNA.
DR   PIR; F84539; F84539.
DR   RefSeq; NP_001323459.1; NM_001335474.1.
DR   RefSeq; NP_565387.1; NM_127192.3.
DR   AlphaFoldDB; Q9SIW3; -.
DR   SMR; Q9SIW3; -.
DR   STRING; 3702.AT2G16380.1; -.
DR   iPTMnet; Q9SIW3; -.
DR   PaxDb; Q9SIW3; -.
DR   PRIDE; Q9SIW3; -.
DR   EnsemblPlants; AT2G16380.1; AT2G16380.1; AT2G16380.
DR   EnsemblPlants; AT2G16380.2; AT2G16380.2; AT2G16380.
DR   GeneID; 816135; -.
DR   Gramene; AT2G16380.1; AT2G16380.1; AT2G16380.
DR   Gramene; AT2G16380.2; AT2G16380.2; AT2G16380.
DR   KEGG; ath:AT2G16380; -.
DR   Araport; AT2G16380; -.
DR   TAIR; locus:2042634; AT2G16380.
DR   eggNOG; KOG1471; Eukaryota.
DR   HOGENOM; CLU_014001_11_1_1; -.
DR   InParanoid; Q9SIW3; -.
DR   OMA; MADTKQD; -.
DR   OrthoDB; 1133487at2759; -.
DR   PhylomeDB; Q9SIW3; -.
DR   PRO; PR:Q9SIW3; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q9SIW3; baseline and differential.
DR   Genevisible; Q9SIW3; AT.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd00170; SEC14; 1.
DR   Gene3D; 3.40.525.10; -; 1.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR   InterPro; IPR011074; CRAL/TRIO_N_dom.
DR   InterPro; IPR036273; CRAL/TRIO_N_dom_sf.
DR   Pfam; PF00650; CRAL_TRIO; 1.
DR   Pfam; PF03765; CRAL_TRIO_N; 1.
DR   SMART; SM01100; CRAL_TRIO_N; 1.
DR   SMART; SM00516; SEC14; 1.
DR   SUPFAM; SSF46938; SSF46938; 1.
DR   SUPFAM; SSF52087; SSF52087; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Coiled coil; Golgi apparatus; Membrane; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..547
FT                   /note="Phosphatidylinositol/phosphatidylcholine transfer
FT                   protein SFH7"
FT                   /id="PRO_0000423467"
FT   DOMAIN          130..304
FT                   /note="CRAL-TRIO"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00056"
FT   COILED          464..526
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   547 AA;  62860 MW;  3280BA2114E4DB88 CRC64;
     MADTKQDMEN SEDGRKLVKM SSLKQKAISA SNRFKNSFKK KTRRTSSKIV SVANTDDING
     DDYLSVEAFR QVLVLDDLLP PKHDDLHMML RFLRARKFDK EKAKQMWSDM LQWRMDFGVD
     TIIEDFEFEE IDQVLKHYPQ GYHGVDKEGR PVYIERLGQI DANKLLQATT MDRYEKYHVK
     EFEKMFKIKF PSCSAAAKKH IDQSTTIFDV QGVGLKNFNK SARELLQRLL KIDNDNYPET
     LNRMFIINAG PGFRLLWAPI KKFLDPKTTS KIHVLGNKYQ PKLLEAIDAS ELPYFFGGLC
     TCADKGGCLR SDKGPWNDPE LLKIARNPEA RFSTISEEDY LLVEEGTSMS MVFEPLERNK
     MKTIEENVSE KHIDAVDKFM ALSLPPKPHL KTLRKGKEPQ KKDDSFLVGG VIAFVMGIVA
     MLRLSKAVPR KLTDVALLTN SVYYEEAKMS KPNQDEVSAP PVSSSEYVIM VKRMAELEEK
     YKSLDSKSAD EALEKDDKLQ AALNRVQVLE HELSETKKAL DETMVNQQGI LAYIEKKNKK
     KRMFFRF