ID   SFI1_PAPAN              Reviewed;        1235 AA.
AC   A9CB34;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 2.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Protein SFI1 homolog;
GN   Name=SFI1;
OS   Papio anubis (Olive baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9555;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Antonellis A., Benjamin B., Blakesley R.W., Bouffard G.G., Brinkley C.,
RA   Brooks S., Chu G., Chub I., Coleman H., Fuksenko T., Gestole M.,
RA   Gregory M., Guan X., Gupta J., Gurson N., Han E., Han J., Hansen N.,
RA   Hargrove A., Hines-Harris K., Ho S.-L., Hu P., Hunter G., Hurle B.,
RA   Idol J.R., Johnson T., Knight E., Kwong P., Lee-Lin S.-Q., Legaspi R.,
RA   Madden M., Maduro Q.L., Maduro V.B., Margulies E.H., Masiello C.,
RA   Maskeri B., McDowell J., Merkulov G., Montemayor C., Mullikin J.C.,
RA   Park M., Prasad A., Ramsahoye C., Reddix-Dugue N., Riebow N., Schandler K.,
RA   Schueler M.G., Sison C., Smith L., Stantripop S., Thomas J.W., Thomas P.J.,
RA   Tsipouri V., Young A., Green E.D.;
RT   "NISC comparative sequencing initiative.";
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in the dynamic structure of centrosome-
CC       associated contractile fibers via its interaction with CETN2.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CETN2 (via C-terminus). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome, centriole {ECO:0000250}. Note=Localized close to
CC       the centriole. {ECO:0000250}.
CC   -!- DOMAIN: CETN2-binding regions contains a conserved Trp residue in their
CC       C-terminal ends, which seems critical for interaction with CETN2.
CC   -!- SIMILARITY: Belongs to the SFI1 family. {ECO:0000305}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-17 is the initiator.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABW96818.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; DP000487; ABW96818.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; NP_001162507.1; NM_001169036.1.
DR   AlphaFoldDB; A9CB34; -.
DR   STRING; 9555.ENSPANP00000013179; -.
DR   GeneID; 100137541; -.
DR   KEGG; panu:100137541; -.
DR   CTD; 9814; -.
DR   eggNOG; KOG4775; Eukaryota.
DR   OrthoDB; 941268at2759; -.
DR   Proteomes; UP000028761; Unplaced.
DR   GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0019902; F:phosphatase binding; ISS:UniProtKB.
DR   InterPro; IPR030516; SFI1.
DR   PANTHER; PTHR22028:SF4; PTHR22028:SF4; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Cytoskeleton; Reference proteome; Repeat.
FT   CHAIN           1..1235
FT                   /note="Protein SFI1 homolog"
FT                   /id="PRO_0000334623"
FT   REPEAT          131..163
FT                   /note="HAT 1"
FT   REPEAT          165..194
FT                   /note="HAT 2"
FT   REPEAT          263..295
FT                   /note="HAT 3"
FT   REPEAT          327..361
FT                   /note="HAT 4"
FT   REPEAT          392..424
FT                   /note="HAT 5"
FT   REPEAT          1141..1173
FT                   /note="HAT 6"
FT   REGION          104..123
FT                   /note="Interaction with CETN2"
FT                   /evidence="ECO:0000250"
FT   REGION          468..487
FT                   /note="Interaction with CETN2"
FT                   /evidence="ECO:0000250"
FT   REGION          634..653
FT                   /note="Interaction with CETN2"
FT                   /evidence="ECO:0000250"
FT   REGION          994..1120
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        994..1020
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1235 AA;  146691 MW;  A22641692263A4A6 CRC64;
     MSSRWLNFHE KMIKQRMEKK VDSRYFRDGA VKKPYSAKTL SNKKSSASFG IRRELPSTSH
     LVQYRGTHTC TRQGRLRELR IRCVARKFLY LWIRMTFGRV FPSKARFYYE QRLLRKVFEE
     WKEEWWVFHH EWKLCVRADC HYRYYLYNLM FQTWKTYVRQ QQEMRNKYTR AEVHDAKQKM
     RQAWKSWLIY VVVRRTKLQM QTTALEFRQR SILRVWWSMW RQQLGQVRVS RALHASAVKH
     RALSLQLQAW SQWREQLLYV QKEKQKVVSA VKHHRHWQKQ RFLKAWLEYL QVRRVKRQQN
     EMAERFHHVS VLQIHFCDWQ QAWEQRQSLY AYHAQVEKLA RKMALRRTFT HWKHYMLLCA
     EEAAQCEMAE EHHRHSQLYF CFRALKDNVT HAHLQQIRRN LAHRQHGVTL LHRFWNLWQS
     QIEEKKEREQ LPLLHAAWDH YRIALLCKCI KLWLQYTQKR RYKQRLQARA DGHFQQRTLP
     AAFHTWKRLW RWRQQDNVLN ARATRFHRET LEKQVFSIWR QKTFQHQENR LAERMAILHA
     ERQLLHRSWF TWHQQAAARH QEQEWQTAAC AHHRHGRLKK AFCLWRESAQ GLRAERTGRV
     RAAEFHVAQL LRRAWSQWRE CLAVRGAERR KLMRADRHHQ QRVRHRALQA WVTYQGRVRS
     ILQEVAARES QHNRQLLRGA LRRWKENTMA RVDEAKKTFQ ASAHYRRTIC SKVLVQWREA
     VSVQIYYRQQ EDSAFWEARK VLDRGCLRTW FQRWRDCSRR SAQQRLQLER AVQHHRRQLL
     LEGLARWKMH HLECVRKRLL HRQSTQLLAQ RLSRTCFRQW RQQLAARRQE QQATVRALWF
     WAFSLQAKVW ATWLAFVLER RRKKARLQRA LQAYQGQLLQ EGATRLLRFA ASMKASRQQL
     QAQQQVQAAH SLHRAVHRCA TLWKQKVLGR GGKPQPLAAV APSRKVTFED PLLNCIAAGA
     GDATVGTKRP QAPLLQGALG CLAAEEPHAR ELNTAHSARK QPRRPHFLLE PARSQRPQKP
     KEHGLGMAQP AGPSLTRPFL AEAPTAQVPH SPGPGALSSA PGPKQIPTAS TGPELLLLPP
     SSFMPCGAAA PARASAQPAT PRDKPQVPPS LASVPDPHLL LPGDFSATRA GPGLSTTGSL
     DLEAELEGIQ QQLLHYQTTK QNLWSCQRQA SSLRRWLELS REEPGPEDQE VEQQVQKELQ
     EVELQIQQLA EELQAQRQPI GTCIARIQAL RQALR