ID   SFI1_SCHPO              Reviewed;         840 AA.
AC   O13652; Q7LWD9;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 3.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Protein sfi1;
DE   AltName: Full=Suppressor of fermentation induced loss of stress resistance protein 1;
GN   Name=sfi1; ORFNames=pi059, SPBC8D2.05c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 115-840.
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=10620777;
RX   DOI=10.1002/(sici)1097-0061(20000115)16:1<71::aid-yea505>3.0.co;2-5;
RA   Machida M., Yamazaki S., Kunihiro S., Tanaka T., Kushida N., Jinno K.,
RA   Haikawa Y., Yamazaki J., Yamamoto S., Sekine M., Oguchi A., Nagai Y.,
RA   Sakai M., Aoki K., Ogura K., Kudoh Y., Kikuchi H., Zhang M.Q., Yanagida M.;
RT   "A 38 kb segment containing the cdc2 gene from the left arm of fission
RT   yeast chromosome II: sequence analysis and characterization of the genomic
RT   DNA and cDNAs encoded on the segment.";
RL   Yeast 16:71-80(2000).
RN   [3]
RP   SUBCELLULAR LOCATION.
RX   PubMed=14504268; DOI=10.1083/jcb.200307064;
RA   Kilmartin J.V.;
RT   "Sfi1p has conserved centrin-binding sites and an essential function in
RT   budding yeast spindle pole body duplication.";
RL   J. Cell Biol. 162:1211-1221(2003).
RN   [4]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Component of the spindle pole body (SPB) half-bridge involved
CC       in the initial steps of SPB duplication. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC       {ECO:0000269|PubMed:10620777, ECO:0000269|PubMed:16823372}. Cytoplasm,
CC       cytoskeleton, spindle pole {ECO:0000269|PubMed:10620777,
CC       ECO:0000269|PubMed:16823372}. Note=Spindle pole, half bridge.
CC       {ECO:0000250|UniProtKB:Q12369}.
CC   -!- SIMILARITY: Belongs to the SFI1 family. {ECO:0000305}.
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DR   EMBL; CU329671; CAA17820.2; -; Genomic_DNA.
DR   EMBL; AB004538; BAA21440.1; -; Genomic_DNA.
DR   PIR; T40750; T40750.
DR   RefSeq; NP_595568.1; NM_001021463.2.
DR   AlphaFoldDB; O13652; -.
DR   BioGRID; 277756; 4.
DR   IntAct; O13652; 3.
DR   MINT; O13652; -.
DR   STRING; 4896.SPBC8D2.05c.1; -.
DR   iPTMnet; O13652; -.
DR   PaxDb; O13652; -.
DR   PRIDE; O13652; -.
DR   EnsemblFungi; SPBC8D2.05c.1; SPBC8D2.05c.1:pep; SPBC8D2.05c.
DR   GeneID; 2541242; -.
DR   KEGG; spo:SPBC8D2.05c; -.
DR   PomBase; SPBC8D2.05c; sfi1.
DR   VEuPathDB; FungiDB:SPBC8D2.05c; -.
DR   eggNOG; KOG4775; Eukaryota.
DR   HOGENOM; CLU_337752_0_0_1; -.
DR   InParanoid; O13652; -.
DR   OMA; WDRATVR; -.
DR   PhylomeDB; O13652; -.
DR   PRO; PR:O13652; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0061496; C:half bridge of mitotic spindle pole body; IDA:PomBase.
DR   GO; GO:0035974; C:meiotic spindle pole body; IDA:PomBase.
DR   GO; GO:0044732; C:mitotic spindle pole body; IDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:1903087; P:mitotic spindle pole body duplication; ISO:PomBase.
DR   InterPro; IPR013665; Sfi1_dom.
DR   Pfam; PF08457; Sfi1; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cytoplasm; Cytoskeleton; Mitosis; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..840
FT                   /note="Protein sfi1"
FT                   /id="PRO_0000290647"
SQ   SEQUENCE   840 AA;  102033 MW;  287E62DCC709184B CRC64;
     MSKNGAPKYV DGGRKIMDED LRRDLEILRL ILLRLSHAAD DTSPLDVFNA YESVLRENGL
     NPARHRSYIR ILYRLISSKK LSWNDEWRNL MRRIGFSQVS SDLNTPLFPL NNTDMENDPF
     IVNGDDYRSR SNQQKSSQFA SEVAQTIKSQ TAMFRRADQY RSQKDKILLA NSLDFMLEKY
     RYYKKIDAVY LRKADAVYRA FIMLKYFPRW VQKLRNIQSR IYSAGEAYRL ILIGQMVNRW
     RQKTRERLHQ KLRFQKNAFL LDVLLKWSAL TVNWNRKHEY MLKRRVFTNW MSKRRRNESL
     IQKANVFFQH SVLAHSFKTW KANLSIKNAA TLYEKKVVFM SFNRWHANYE SHVLDLQKAE
     LFSQKAYYSI ALHKWKLRIE ELSDLMNKAD DLYEVNLLQR MLVLWRRKAT TYEKIDFWMD
     GHDVDIVKSA FFKWKNKFIK VDRNFELADT ILQNTFLTKW RLAVRVKVVQ EKRNKDRLIV
     TFRFWYYLMK AKSFQHKRDH RLLTIAWEAW KDNYQRRIKL QKEAQELQLT RIQKIAKQYL
     IKWRISLLDI KELSIRAEKL HTTNEIIGVW NQWVVSYNRK VGMQQNADLF FKRKTLRVVF
     EHWRYLRETN MLLRLENKVV DFREVQSEKL VLRCWNAWVA RLLSVSQMLD TAELSTQKVV
     VRAYEAWSFR YNHQKEIMSQ ADQFYNERLM RSAMVFWRYQ LRAIKFYFNI SDWKRREFNR
     QTLRNAFDAW HLLMFRVTSL VMQADRFHEQ KKNKLLGKYF RKWLQRMQLN QEESSLLEAE
     ATIEGNRTSR YMHTFDTTLP MQNDEFTDES VNFENRWKQE LKTPISRFSK FLRPIPPNTR