ID   SFI2_PHYIT              Reviewed;         128 AA.
AC   D0N0N6;
DT   08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2009, sequence version 1.
DT   03-AUG-2022, entry version 33.
DE   RecName: Full=RxLR effector protein SFI2 {ECO:0000303|PubMed:24763622};
DE   AltName: Full=Suppressor of early Flg22-induced immune response 2 {ECO:0000303|PubMed:24763622};
DE   Flags: Precursor;
GN   Name=SFI2 {ECO:0000303|PubMed:24763622}; ORFNames=PITG_04145;
OS   Phytophthora infestans (strain T30-4) (Potato late blight agent).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Phytophthora.
OX   NCBI_TaxID=403677;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T30-4;
RX   PubMed=19741609; DOI=10.1038/nature08358;
RG   The Broad Institute Genome Sequencing Platform;
RA   Haas B.J., Kamoun S., Zody M.C., Jiang R.H., Handsaker R.E., Cano L.M.,
RA   Grabherr M., Kodira C.D., Raffaele S., Torto-Alalibo T., Bozkurt T.O.,
RA   Ah-Fong A.M., Alvarado L., Anderson V.L., Armstrong M.R., Avrova A.,
RA   Baxter L., Beynon J., Boevink P.C., Bollmann S.R., Bos J.I., Bulone V.,
RA   Cai G., Cakir C., Carrington J.C., Chawner M., Conti L., Costanzo S.,
RA   Ewan R., Fahlgren N., Fischbach M.A., Fugelstad J., Gilroy E.M., Gnerre S.,
RA   Green P.J., Grenville-Briggs L.J., Griffith J., Grunwald N.J., Horn K.,
RA   Horner N.R., Hu C.H., Huitema E., Jeong D.H., Jones A.M., Jones J.D.,
RA   Jones R.W., Karlsson E.K., Kunjeti S.G., Lamour K., Liu Z., Ma L.,
RA   Maclean D., Chibucos M.C., McDonald H., McWalters J., Meijer H.J.,
RA   Morgan W., Morris P.F., Munro C.A., O'Neill K., Ospina-Giraldo M.,
RA   Pinzon A., Pritchard L., Ramsahoye B., Ren Q., Restrepo S., Roy S.,
RA   Sadanandom A., Savidor A., Schornack S., Schwartz D.C., Schumann U.D.,
RA   Schwessinger B., Seyer L., Sharpe T., Silvar C., Song J., Studholme D.J.,
RA   Sykes S., Thines M., van de Vondervoort P.J., Phuntumart V., Wawra S.,
RA   Weide R., Win J., Young C., Zhou S., Fry W., Meyers B.C., van West P.,
RA   Ristaino J., Govers F., Birch P.R., Whisson S.C., Judelson H.S.,
RA   Nusbaum C.;
RT   "Genome sequence and analysis of the Irish potato famine pathogen
RT   Phytophthora infestans.";
RL   Nature 461:393-398(2009).
RN   [2]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=24763622; DOI=10.1371/journal.ppat.1004057;
RA   Zheng X., McLellan H., Fraiture M., Liu X., Boevink P.C., Gilroy E.M.,
RA   Chen Y., Kandel K., Sessa G., Birch P.R., Brunner F.;
RT   "Functionally redundant RXLR effectors from Phytophthora infestans act at
RT   different steps to suppress early flg22-triggered immunity.";
RL   PLoS Pathog. 10:E1004057-E1004057(2014).
CC   -!- FUNCTION: Effector that suppresses flg22-induced post-translational MAP
CC       kinase activation both tomato and Arabidopsis.The perception of highly
CC       conserved pathogen- or microbe-associated molecular patterns
CC       (PAMPs/MAMPs), such as flg22, triggers converging signaling pathways
CC       recruiting MAP kinase cascades and inducing transcriptional re-
CC       programming, yielding a generic antimicrobial response.
CC       {ECO:0000269|PubMed:24763622}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:24763622}. Host
CC       nucleus {ECO:0000269|PubMed:24763622}.
CC   -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC       cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC       phosphate. {ECO:0000305|PubMed:24763622}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DS028122; EEY67199.1; -; Genomic_DNA.
DR   RefSeq; XP_002905847.1; XM_002905801.1.
DR   AlphaFoldDB; D0N0N6; -.
DR   EnsemblProtists; PITG_04145T0; PITG_04145T0; PITG_04145.
DR   GeneID; 9479716; -.
DR   KEGG; pif:PITG_04145; -.
DR   VEuPathDB; FungiDB:PITG_04145; -.
DR   HOGENOM; CLU_126839_0_0_1; -.
DR   InParanoid; D0N0N6; -.
DR   OrthoDB; 1827347at2759; -.
DR   Proteomes; UP000006643; Partially assembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Host nucleus; Reference proteome; Secreted; Signal; Virulence.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..128
FT                   /note="RxLR effector protein SFI2"
FT                   /id="PRO_5003011571"
FT   MOTIF           52..71
FT                   /note="RxLR-dEER"
FT                   /evidence="ECO:0000305|PubMed:24763622"
SQ   SEQUENCE   128 AA;  13907 MW;  410360921579193F CRC64;
     MRSAFYIFLV VAVLARCSVV AAFTNADDSQ LLSKVSPDFA ANDMTYTVSR KRLLRVAGRE
     DDDATTDEED RGFTSIVDVI KRSDAAEALH KLSKASAKKV KKAGKAVKEL TAKEKEALKA
     LLALKDGN