SFI4_PHYIT
ID SFI4_PHYIT Reviewed; 339 AA.
AC D0NCC1;
DT 08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2009, sequence version 1.
DT 03-AUG-2022, entry version 53.
DE RecName: Full=RxLR effector protein SFI4 {ECO:0000303|PubMed:24763622};
DE AltName: Full=Suppressor of early Flg22-induced immune response 4 {ECO:0000303|PubMed:24763622};
DE Flags: Precursor;
GN Name=SFI4 {ECO:0000303|PubMed:24763622}; ORFNames=PITG_09585;
OS Phytophthora infestans (strain T30-4) (Potato late blight agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=403677;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T30-4;
RX PubMed=19741609; DOI=10.1038/nature08358;
RG The Broad Institute Genome Sequencing Platform;
RA Haas B.J., Kamoun S., Zody M.C., Jiang R.H., Handsaker R.E., Cano L.M.,
RA Grabherr M., Kodira C.D., Raffaele S., Torto-Alalibo T., Bozkurt T.O.,
RA Ah-Fong A.M., Alvarado L., Anderson V.L., Armstrong M.R., Avrova A.,
RA Baxter L., Beynon J., Boevink P.C., Bollmann S.R., Bos J.I., Bulone V.,
RA Cai G., Cakir C., Carrington J.C., Chawner M., Conti L., Costanzo S.,
RA Ewan R., Fahlgren N., Fischbach M.A., Fugelstad J., Gilroy E.M., Gnerre S.,
RA Green P.J., Grenville-Briggs L.J., Griffith J., Grunwald N.J., Horn K.,
RA Horner N.R., Hu C.H., Huitema E., Jeong D.H., Jones A.M., Jones J.D.,
RA Jones R.W., Karlsson E.K., Kunjeti S.G., Lamour K., Liu Z., Ma L.,
RA Maclean D., Chibucos M.C., McDonald H., McWalters J., Meijer H.J.,
RA Morgan W., Morris P.F., Munro C.A., O'Neill K., Ospina-Giraldo M.,
RA Pinzon A., Pritchard L., Ramsahoye B., Ren Q., Restrepo S., Roy S.,
RA Sadanandom A., Savidor A., Schornack S., Schwartz D.C., Schumann U.D.,
RA Schwessinger B., Seyer L., Sharpe T., Silvar C., Song J., Studholme D.J.,
RA Sykes S., Thines M., van de Vondervoort P.J., Phuntumart V., Wawra S.,
RA Weide R., Win J., Young C., Zhou S., Fry W., Meyers B.C., van West P.,
RA Ristaino J., Govers F., Birch P.R., Whisson S.C., Judelson H.S.,
RA Nusbaum C.;
RT "Genome sequence and analysis of the Irish potato famine pathogen
RT Phytophthora infestans.";
RL Nature 461:393-398(2009).
RN [2]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=24763622; DOI=10.1371/journal.ppat.1004057;
RA Zheng X., McLellan H., Fraiture M., Liu X., Boevink P.C., Gilroy E.M.,
RA Chen Y., Kandel K., Sessa G., Birch P.R., Brunner F.;
RT "Functionally redundant RXLR effectors from Phytophthora infestans act at
RT different steps to suppress early flg22-triggered immunity.";
RL PLoS Pathog. 10:E1004057-E1004057(2014).
CC -!- FUNCTION: Effector that suppresses flg22-induced post-translational MAP
CC kinase activation in tomato but not in Arabidopsis. The perception of
CC highly conserved pathogen- or microbe-associated molecular patterns
CC (PAMPs/MAMPs), such as flg22, triggers converging signaling pathways
CC recruiting MAP kinase cascades and inducing transcriptional re-
CC programming, yielding a generic antimicrobial response.
CC {ECO:0000269|PubMed:24763622}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:24763622}. Host
CC nucleus {ECO:0000269|PubMed:24763622}. Host cytoplasm
CC {ECO:0000269|PubMed:24763622}.
CC -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC phosphate. {ECO:0000305|PubMed:24763622}.
CC -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR EMBL; DS028132; EEY55635.1; -; Genomic_DNA.
DR RefSeq; XP_002903211.1; XM_002903165.1.
DR AlphaFoldDB; D0NCC1; -.
DR SMR; D0NCC1; -.
DR EnsemblProtists; PITG_09585T0; PITG_09585T0; PITG_09585.
DR GeneID; 9461552; -.
DR KEGG; pif:PITG_09585; -.
DR VEuPathDB; FungiDB:PITG_09585; -.
DR eggNOG; ENOG502QWHW; Eukaryota.
DR HOGENOM; CLU_751192_0_0_1; -.
DR InParanoid; D0NCC1; -.
DR OMA; VTHEAYI; -.
DR OrthoDB; 992218at2759; -.
DR PHI-base; PHI:4203; -.
DR Proteomes; UP000006643; Partially assembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF48452; SSF48452; 2.
DR PROSITE; PS50293; TPR_REGION; 2.
PE 3: Inferred from homology;
KW Host cytoplasm; Host nucleus; Reference proteome; Repeat; Secreted; Signal;
KW TPR repeat; Virulence.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..339
FT /note="RxLR effector protein SFI4"
FT /id="PRO_5003013215"
FT REPEAT 106..139
FT /note="TPR 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00339"
FT REPEAT 190..223
FT /note="TPR 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00339"
FT REPEAT 232..265
FT /note="TPR 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00339"
FT REPEAT 274..307
FT /note="TPR 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00339"
FT MOTIF 51..74
FT /note="RxLR-dEER"
FT /evidence="ECO:0000305|PubMed:24763622"
SQ SEQUENCE 339 AA; 37575 MW; 464E7107CC7BCA65 CRC64;
MRVLRVTFLW ALLLLVAFSA SVYAAEDEPK TPESTSSANP RDNDPVIQEI RGLRNSGMKL
NDAKDFKGAI AKLRGAITLL HDRVFGEGRE AITDPSDISQ DAALYAQILN DYGTVLIRAK
QYDEAIEVLE DSVAMVEKIY GDSHPSLGLS LRSLADAYMA KEEYKMAIKK YKTLRKHVKK
GLETTHEAYI EASLRIAEGY KKLGNTKKNL KVLKDAVEAQ NGEINGLTTG IAELYMELST
AHVAVGEIDD ALRAAEVASA IFRQRDGEDT LSFAFSLNAL AGVKMRQKKV DEAIKLLEQA
HRIAVQIYGE KDPITQASAK TLREVKEYKL DLQAQKDEL
