ID   SFI6_PHYIT              Reviewed;         129 AA.
AC   D0NN72;
DT   08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2009, sequence version 1.
DT   03-AUG-2022, entry version 36.
DE   RecName: Full=RxLR effector protein SFI6 {ECO:0000303|PubMed:24763622};
DE   AltName: Full=Suppressor of early Flg22-induced immune response 6 {ECO:0000303|PubMed:24763622};
DE   Flags: Precursor;
GN   Name=SFI6 {ECO:0000303|PubMed:24763622}; ORFNames=PITG_13959;
OS   Phytophthora infestans (strain T30-4) (Potato late blight agent).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Phytophthora.
OX   NCBI_TaxID=403677;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T30-4;
RX   PubMed=19741609; DOI=10.1038/nature08358;
RG   The Broad Institute Genome Sequencing Platform;
RA   Haas B.J., Kamoun S., Zody M.C., Jiang R.H., Handsaker R.E., Cano L.M.,
RA   Grabherr M., Kodira C.D., Raffaele S., Torto-Alalibo T., Bozkurt T.O.,
RA   Ah-Fong A.M., Alvarado L., Anderson V.L., Armstrong M.R., Avrova A.,
RA   Baxter L., Beynon J., Boevink P.C., Bollmann S.R., Bos J.I., Bulone V.,
RA   Cai G., Cakir C., Carrington J.C., Chawner M., Conti L., Costanzo S.,
RA   Ewan R., Fahlgren N., Fischbach M.A., Fugelstad J., Gilroy E.M., Gnerre S.,
RA   Green P.J., Grenville-Briggs L.J., Griffith J., Grunwald N.J., Horn K.,
RA   Horner N.R., Hu C.H., Huitema E., Jeong D.H., Jones A.M., Jones J.D.,
RA   Jones R.W., Karlsson E.K., Kunjeti S.G., Lamour K., Liu Z., Ma L.,
RA   Maclean D., Chibucos M.C., McDonald H., McWalters J., Meijer H.J.,
RA   Morgan W., Morris P.F., Munro C.A., O'Neill K., Ospina-Giraldo M.,
RA   Pinzon A., Pritchard L., Ramsahoye B., Ren Q., Restrepo S., Roy S.,
RA   Sadanandom A., Savidor A., Schornack S., Schwartz D.C., Schumann U.D.,
RA   Schwessinger B., Seyer L., Sharpe T., Silvar C., Song J., Studholme D.J.,
RA   Sykes S., Thines M., van de Vondervoort P.J., Phuntumart V., Wawra S.,
RA   Weide R., Win J., Young C., Zhou S., Fry W., Meyers B.C., van West P.,
RA   Ristaino J., Govers F., Birch P.R., Whisson S.C., Judelson H.S.,
RA   Nusbaum C.;
RT   "Genome sequence and analysis of the Irish potato famine pathogen
RT   Phytophthora infestans.";
RL   Nature 461:393-398(2009).
RN   [2]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=24763622; DOI=10.1371/journal.ppat.1004057;
RA   Zheng X., McLellan H., Fraiture M., Liu X., Boevink P.C., Gilroy E.M.,
RA   Chen Y., Kandel K., Sessa G., Birch P.R., Brunner F.;
RT   "Functionally redundant RXLR effectors from Phytophthora infestans act at
RT   different steps to suppress early flg22-triggered immunity.";
RL   PLoS Pathog. 10:E1004057-E1004057(2014).
CC   -!- FUNCTION: Effector that suppresses flg22-induced post-translational MAP
CC       kinase activation in tomato but not in Arabidopsis. The perception of
CC       highly conserved pathogen- or microbe-associated molecular patterns
CC       (PAMPs/MAMPs), such as flg22, triggers converging signaling pathways
CC       recruiting MAP kinase cascades and inducing transcriptional re-
CC       programming, yielding a generic antimicrobial response.
CC       {ECO:0000269|PubMed:24763622}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:24763622}. Host
CC       cytoplasm {ECO:0000269|PubMed:24763622}. Host cell membrane
CC       {ECO:0000269|PubMed:24763622}.
CC   -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC       cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC       phosphate. {ECO:0000305|PubMed:24763622}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   EMBL; DS028147; EEY61979.1; -; Genomic_DNA.
DR   RefSeq; XP_002899619.1; XM_002899573.1.
DR   AlphaFoldDB; D0NN72; -.
DR   EnsemblProtists; PITG_13959T0; PITG_13959T0; PITG_13959.
DR   GeneID; 9461650; -.
DR   KEGG; pif:PITG_13959; -.
DR   VEuPathDB; FungiDB:PITG_13959; -.
DR   eggNOG; ENOG502RGY9; Eukaryota.
DR   HOGENOM; CLU_1790698_0_0_1; -.
DR   InParanoid; D0NN72; -.
DR   OMA; YRDKEFQ; -.
DR   OrthoDB; 1515690at2759; -.
DR   PHI-base; PHI:4205; -.
DR   Proteomes; UP000006643; Partially assembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR031825; RXLR.
DR   Pfam; PF16810; RXLR; 1.
PE   3: Inferred from homology;
KW   Host cell membrane; Host cytoplasm; Host membrane; Membrane;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..129
FT                   /note="RxLR effector protein SFI6"
FT                   /id="PRO_5003012234"
FT   MOTIF           42..64
FT                   /note="RxLR-dEER"
FT                   /evidence="ECO:0000305|PubMed:24763622"
SQ   SEQUENCE   129 AA;  14431 MW;  DCA041C39B73EA1B CRC64;
     MTLVVLATGL LASGTAVSNA DQASELNVDV HSSNVLATED TRFLRSHQIT DDKVEINEHG
     EEERMSGSNL FSALKLEKMG RDTSYRDKEF QRWKNYGNSV GDVTPHVPVS LKEAYATYLR
     IREMVLVND