SFI7_PHYIT
ID SFI7_PHYIT Reviewed; 148 AA.
AC D0NXM3;
DT 08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2009, sequence version 1.
DT 03-AUG-2022, entry version 35.
DE RecName: Full=RxLR effector protein SFI7 {ECO:0000303|PubMed:24763622};
DE AltName: Full=Suppressor of early Flg22-induced immune response 7 {ECO:0000303|PubMed:24763622};
DE Flags: Precursor;
GN Name=SFI7 {ECO:0000303|PubMed:24763622}; ORFNames=PITG_18215;
OS Phytophthora infestans (strain T30-4) (Potato late blight agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=403677;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T30-4;
RX PubMed=19741609; DOI=10.1038/nature08358;
RG The Broad Institute Genome Sequencing Platform;
RA Haas B.J., Kamoun S., Zody M.C., Jiang R.H., Handsaker R.E., Cano L.M.,
RA Grabherr M., Kodira C.D., Raffaele S., Torto-Alalibo T., Bozkurt T.O.,
RA Ah-Fong A.M., Alvarado L., Anderson V.L., Armstrong M.R., Avrova A.,
RA Baxter L., Beynon J., Boevink P.C., Bollmann S.R., Bos J.I., Bulone V.,
RA Cai G., Cakir C., Carrington J.C., Chawner M., Conti L., Costanzo S.,
RA Ewan R., Fahlgren N., Fischbach M.A., Fugelstad J., Gilroy E.M., Gnerre S.,
RA Green P.J., Grenville-Briggs L.J., Griffith J., Grunwald N.J., Horn K.,
RA Horner N.R., Hu C.H., Huitema E., Jeong D.H., Jones A.M., Jones J.D.,
RA Jones R.W., Karlsson E.K., Kunjeti S.G., Lamour K., Liu Z., Ma L.,
RA Maclean D., Chibucos M.C., McDonald H., McWalters J., Meijer H.J.,
RA Morgan W., Morris P.F., Munro C.A., O'Neill K., Ospina-Giraldo M.,
RA Pinzon A., Pritchard L., Ramsahoye B., Ren Q., Restrepo S., Roy S.,
RA Sadanandom A., Savidor A., Schornack S., Schwartz D.C., Schumann U.D.,
RA Schwessinger B., Seyer L., Sharpe T., Silvar C., Song J., Studholme D.J.,
RA Sykes S., Thines M., van de Vondervoort P.J., Phuntumart V., Wawra S.,
RA Weide R., Win J., Young C., Zhou S., Fry W., Meyers B.C., van West P.,
RA Ristaino J., Govers F., Birch P.R., Whisson S.C., Judelson H.S.,
RA Nusbaum C.;
RT "Genome sequence and analysis of the Irish potato famine pathogen
RT Phytophthora infestans.";
RL Nature 461:393-398(2009).
RN [2]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=24763622; DOI=10.1371/journal.ppat.1004057;
RA Zheng X., McLellan H., Fraiture M., Liu X., Boevink P.C., Gilroy E.M.,
RA Chen Y., Kandel K., Sessa G., Birch P.R., Brunner F.;
RT "Functionally redundant RXLR effectors from Phytophthora infestans act at
RT different steps to suppress early flg22-triggered immunity.";
RL PLoS Pathog. 10:E1004057-E1004057(2014).
CC -!- FUNCTION: Effector that suppresses flg22-induced post-translational MAP
CC kinase activation in tomato but not in Arabidopsis. The perception of
CC highly conserved pathogen- or microbe-associated molecular patterns
CC (PAMPs/MAMPs), such as flg22, triggers converging signaling pathways
CC recruiting MAP kinase cascades and inducing transcriptional re-
CC programming, yielding a generic antimicrobial response
CC (PubMed:24763622). Also partially attenuates INF1-triggered cell death
CC (PubMed:24763622). {ECO:0000269|PubMed:24763622}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:24763622}. Host
CC cytoplasm {ECO:0000269|PubMed:24763622}. Host cell membrane
CC {ECO:0000269|PubMed:24763622}.
CC -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC phosphate. {ECO:0000305|PubMed:24763622}.
CC -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR EMBL; DS028183; EEY67823.1; -; Genomic_DNA.
DR RefSeq; XP_002997848.1; XM_002997802.1.
DR AlphaFoldDB; D0NXM3; -.
DR SMR; D0NXM3; -.
DR EnsemblProtists; PITG_18215T0; PITG_18215T0; PITG_18215.
DR GeneID; 9463553; -.
DR KEGG; pif:PITG_18215; -.
DR VEuPathDB; FungiDB:PITG_18215; -.
DR eggNOG; ENOG502RGPZ; Eukaryota.
DR HOGENOM; CLU_120310_0_0_1; -.
DR OMA; QNWDALV; -.
DR OrthoDB; 1788836at2759; -.
DR PHI-base; PHI:4206; -.
DR Proteomes; UP000006643; Partially assembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
PE 3: Inferred from homology;
KW Glycoprotein; Host cell membrane; Host cytoplasm; Host membrane; Membrane;
KW Reference proteome; Secreted; Signal; Virulence.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..148
FT /note="RxLR effector protein SFI7"
FT /id="PRO_5003013718"
FT MOTIF 44..58
FT /note="RxLR-dEER"
FT /evidence="ECO:0000305|PubMed:24763622"
FT CARBOHYD 32
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 148 AA; 16443 MW; E133290C0E68657E CRC64;
MRAYFVLLVA ATAILTYGGA TATYSTSKGE MNLTGTVENN RPTRSLRVAP SGGNGEERSW
STIYGISRSK AETVRDWLMP RLNQGMDVQA LAREMGITSR QAATQHQNWD ALVKYLKMYN
YAVRGEKMSK SMAESVLLHN VLTAKNNF