SFK1_SCHPO
ID SFK1_SCHPO Reviewed; 328 AA.
AC Q9Y7U1;
DT 14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Protein sfk1;
GN Name=sfk1; ORFNames=SPCC16A11.01, SPCC63.15;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: May control the production of phosphatidylinositol 4-
CC phosphate (PI4P). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SFK1 family. {ECO:0000305}.
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DR EMBL; CU329672; CAB40019.1; -; Genomic_DNA.
DR PIR; T41074; T41074.
DR RefSeq; NP_587988.1; NM_001022979.2.
DR AlphaFoldDB; Q9Y7U1; -.
DR BioGRID; 275794; 11.
DR STRING; 4896.SPCC16A11.01.1; -.
DR iPTMnet; Q9Y7U1; -.
DR PaxDb; Q9Y7U1; -.
DR PRIDE; Q9Y7U1; -.
DR EnsemblFungi; SPCC16A11.01.1; SPCC16A11.01.1:pep; SPCC16A11.01.
DR GeneID; 2539224; -.
DR KEGG; spo:SPCC16A11.01; -.
DR PomBase; SPCC16A11.01; sfk1.
DR VEuPathDB; FungiDB:SPCC16A11.01; -.
DR eggNOG; ENOG502RZQS; Eukaryota.
DR HOGENOM; CLU_087070_0_0_1; -.
DR InParanoid; Q9Y7U1; -.
DR PhylomeDB; Q9Y7U1; -.
DR PRO; PR:Q9Y7U1; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0005887; C:integral component of plasma membrane; ISO:PomBase.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0048017; P:inositol lipid-mediated signaling; ISO:PomBase.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR InterPro; IPR019402; Frag1/DRAM/Sfk1.
DR Pfam; PF10277; Frag1; 1.
PE 3: Inferred from homology;
KW Cell membrane; Lipid biosynthesis; Lipid metabolism; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..328
FT /note="Protein sfk1"
FT /id="PRO_0000351442"
FT TOPO_DOM 1..19
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 41..69
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 91..109
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 131..142
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 164..178
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 200..213
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..234
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 235..328
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 328 AA; 36917 MW; 6C8FA43BA9AE3F6A CRC64;
MDNDYTTSTT TSRRPRFWGF FFILFPLVSF LMWTIGLIVL LGLWSTQDKW HTPSEPDPVY
LSDMGAYTKG FFIPMCVITG VFYFLTFIMI RLARQWGWIY PTGRKVETYL GWFAALTGAA
AASCLISLSI RDDVHHDNVH WKFTAAFVVL AFVSAASNIF EWLSATRYYP QSSLLRVSFI
FKFVIIVVGI ICAIAFGGLH HNYRGRSARF EWVVCFLWSI YICLLCLDLA PALFYDSLAS
APDLEKGAYA TSVPESYVAP MEPPAAVLPD GEERYATPDL VPDTTAQYPY ASATEPGVSN
IPETRPERPV VYNMDVSQTT TTTRPVLA
