ID   SFMA_ECOLI              Reviewed;         180 AA.
AC   P0ABW5; P77660; Q2MBP9;
DT   25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Uncharacterized fimbrial-like protein SfmA;
DE   AltName: Full=Type-1A pilin;
DE   Flags: Precursor;
GN   Name=sfmA; OrderedLocusNames=b0530, JW0519;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RA   Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M.,
RA   Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D.,
RA   Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
RT   "Sequence of minutes 4-25 of Escherichia coli.";
RL   Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=20345943; DOI=10.1111/j.1462-2920.2010.02202.x;
RA   Korea C.G., Badouraly R., Prevost M.C., Ghigo J.M., Beloin C.;
RT   "Escherichia coli K-12 possesses multiple cryptic but functional chaperone-
RT   usher fimbriae with distinct surface specificities.";
RL   Environ. Microbiol. 12:1957-1977(2010).
CC   -!- FUNCTION: Part of the sfmACDHF fimbrial operon. Could contribute to
CC       adhesion to various surfaces in specific environmental niches.
CC       Increases adhesion to eukaryotic T24 bladder epithelial cells in the
CC       absence of fim genes. {ECO:0000269|PubMed:20345943}.
CC   -!- SUBCELLULAR LOCATION: Fimbrium {ECO:0000250}.
CC   -!- INDUCTION: Expression is negatively regulated by H-NS and subjected to
CC       cAMP receptor protein (CRP)-mediated catabolite repression.
CC       {ECO:0000269|PubMed:20345943}.
CC   -!- DISRUPTION PHENOTYPE: Deletion of the operon under classical laboratory
CC       conditions does not result in any major effect on E.coli capacity to
CC       form biofilms compared with the wild-type strain.
CC       {ECO:0000269|PubMed:20345943}.
CC   -!- MISCELLANEOUS: The operon is cryptic under classical laboratory
CC       conditions, but is functional when constitutively expressed.
CC       {ECO:0000305|PubMed:20345943}.
CC   -!- SIMILARITY: Belongs to the fimbrial protein family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB40283.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U82664; AAB40283.1; ALT_INIT; Genomic_DNA.
DR   EMBL; U00096; AAC73632.2; -; Genomic_DNA.
DR   EMBL; AP009048; BAE76307.1; -; Genomic_DNA.
DR   PIR; A64785; A64785.
DR   RefSeq; NP_415063.4; NC_000913.3.
DR   RefSeq; WP_000776555.1; NZ_STEB01000007.1.
DR   AlphaFoldDB; P0ABW5; -.
DR   SMR; P0ABW5; -.
DR   BioGRID; 4259878; 15.
DR   BioGRID; 849896; 13.
DR   IntAct; P0ABW5; 13.
DR   STRING; 511145.b0530; -.
DR   PaxDb; P0ABW5; -.
DR   EnsemblBacteria; AAC73632; AAC73632; b0530.
DR   EnsemblBacteria; BAE76307; BAE76307; BAE76307.
DR   GeneID; 58462029; -.
DR   GeneID; 945522; -.
DR   KEGG; ecj:JW0519; -.
DR   KEGG; eco:b0530; -.
DR   PATRIC; fig|1411691.4.peg.1748; -.
DR   EchoBASE; EB3640; -.
DR   eggNOG; COG3539; Bacteria.
DR   HOGENOM; CLU_088965_0_0_6; -.
DR   InParanoid; P0ABW5; -.
DR   OMA; ATFVMKY; -.
DR   PhylomeDB; P0ABW5; -.
DR   BioCyc; EcoCyc:G6290-MON; -.
DR   PRO; PR:P0ABW5; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0009289; C:pilus; IBA:GO_Central.
DR   GO; GO:0007155; P:cell adhesion; IMP:EcoCyc.
DR   GO; GO:0043709; P:cell adhesion involved in single-species biofilm formation; IBA:GO_Central.
DR   Gene3D; 2.60.40.1090; -; 1.
DR   InterPro; IPR000259; Adhesion_dom_fimbrial.
DR   InterPro; IPR036937; Adhesion_dom_fimbrial_sf.
DR   InterPro; IPR008966; Adhesion_dom_sf.
DR   Pfam; PF00419; Fimbrial; 1.
DR   SUPFAM; SSF49401; SSF49401; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Fimbrium; Reference proteome; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..180
FT                   /note="Uncharacterized fimbrial-like protein SfmA"
FT                   /id="PRO_0000009174"
FT   DISULFID        41..81
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   180 AA;  18475 MW;  2D5CDA1585FC6EA9 CRC64;
     MKLRFISSAL AAALFAATGS YAAVVDGGTI HFEGELVNAA CSVNTDSADQ VVTLGQYRTD
     IFNAVGNTSA LIPFTIQLND CDPVVAANAA VAFSGQADAI NDNLLAIASS TNTTTATGVG
     IEILDNTSAI LKPDGNSFST NQNLIPGTNV LHFSARYKGT GTSASAGQAN ADATFIMRYE