SFR1_CHICK
ID SFR1_CHICK Reviewed; 222 AA.
AC E1BXS0;
DT 05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2010, sequence version 1.
DT 03-AUG-2022, entry version 60.
DE RecName: Full=Swi5-dependent recombination DNA repair protein 1 homolog;
DE AltName: Full=Meiosis protein 5 homolog;
GN Name=SFR1; Synonyms=MEI5, MEIR5;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Red jungle fowl;
RX PubMed=15592404; DOI=10.1038/nature03154;
RA Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P.,
RA Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B.,
RA Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C.,
RA Fulton R.S., Graves T.A., Kremitzki C., Layman D., Magrini V.,
RA McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O.,
RA Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W.,
RA Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D.,
RA Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K.,
RA Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L.,
RA Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B.,
RA Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M.,
RA Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M.,
RA Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S.,
RA Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M.,
RA Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M.,
RA Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A.,
RA Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S.,
RA Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J.,
RA Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J.,
RA Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E.,
RA Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M.,
RA Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A.,
RA Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E.,
RA Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S.,
RA Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E.,
RA Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R.,
RA Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R.,
RA Wilson R.K.;
RT "Sequence and comparative analysis of the chicken genome provide unique
RT perspectives on vertebrate evolution.";
RL Nature 432:695-716(2004).
CC -!- FUNCTION: Component of the SWI5-SFR1 complex, a complex required for
CC double-strand break repair via homologous recombination (By
CC similarity). May act as a transcriptional modulator for ESR1 (By
CC similarity). {ECO:0000250|UniProtKB:Q86XK3}.
CC -!- SUBUNIT: Component of the swi5-sfr1 complex.
CC {ECO:0000250|UniProtKB:Q86XK3}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8BP27}.
CC -!- SIMILARITY: Belongs to the SFR1/MEI5 family. {ECO:0000305}.
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DR EMBL; AADN02030847; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_001234168.2; XM_001234167.4.
DR AlphaFoldDB; E1BXS0; -.
DR SMR; E1BXS0; -.
DR STRING; 9031.ENSGALP00000013642; -.
DR PaxDb; E1BXS0; -.
DR Ensembl; ENSGALT00000103201; ENSGALP00000072976; ENSGALG00000052088.
DR GeneID; 770846; -.
DR CTD; 119392; -.
DR VEuPathDB; HostDB:geneid_770846; -.
DR eggNOG; ENOG502S1QX; Eukaryota.
DR GeneTree; ENSGT00390000018550; -.
DR HOGENOM; CLU_075586_1_0_1; -.
DR InParanoid; E1BXS0; -.
DR OMA; RNEEEFM; -.
DR OrthoDB; 1628702at2759; -.
DR PhylomeDB; E1BXS0; -.
DR TreeFam; TF332725; -.
DR PRO; PR:E1BXS0; -.
DR Proteomes; UP000000539; Chromosome 6.
DR Bgee; ENSGALG00000052088; Expressed in spermatid and 11 other tissues.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0032798; C:Swi5-Sfr1 complex; ISS:UniProtKB.
DR GO; GO:0030374; F:nuclear receptor coactivator activity; IBA:GO_Central.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR InterPro; IPR042429; SFR1.
DR InterPro; IPR018468; SFR1/Mei5.
DR PANTHER; PTHR28643; PTHR28643; 1.
DR Pfam; PF10376; Mei5; 1.
PE 3: Inferred from homology;
KW Coiled coil; DNA damage; DNA repair; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..222
FT /note="Swi5-dependent recombination DNA repair protein 1
FT homolog"
FT /id="PRO_0000406976"
FT REGION 16..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 130..155
FT /evidence="ECO:0000255"
FT COMPBIAS 16..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 222 AA; 25176 MW; 1AB5DD60192E520A CRC64;
MEEAACGKLT SLCHTPKDSG TAAPQRTSSG KQPMSATLRE RLRKTRRSFT TNFAVAKRLK
VDTEEKDCTD VDNRCLPKIG MDCSTLQDGS ECLEQNCTVN TYFKSPLQEN NLCESAENVV
RVDLGQQQSL GEKVRLMKQV KEKEELLRRL KLVKMYRSKN NLSELQALIV KWRSSTQLML
YELQAAFSAD GKKVSLSQLI DTFGLEDHLL HYSRAEEDFV DT
