ID   SFR1_DANRE              Reviewed;         201 AA.
AC   B7ZD04; A3KNK5;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Swi5-dependent recombination DNA repair protein 1 homolog;
DE   AltName: Full=Meiosis protein 5 homolog;
GN   Name=sfr1; Synonyms=mei5, meir5; ORFNames=si:ch211-223p8.4, zgc:162162;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the swi5-sfr1 complex, a complex required for
CC       double-strand break repair via homologous recombination.
CC       {ECO:0000250|UniProtKB:Q86XK3}.
CC   -!- SUBUNIT: Component of the swi5-sfr1 complex.
CC       {ECO:0000250|UniProtKB:Q86XK3}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8BP27}.
CC   -!- SIMILARITY: Belongs to the SFR1/MEI5 family. {ECO:0000305}.
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DR   EMBL; AL929005; CAX14339.1; -; Genomic_DNA.
DR   EMBL; BC133892; AAI33893.1; -; mRNA.
DR   RefSeq; NP_001076329.1; NM_001082860.1.
DR   AlphaFoldDB; B7ZD04; -.
DR   SMR; B7ZD04; -.
DR   STRING; 7955.ENSDARP00000037070; -.
DR   PaxDb; B7ZD04; -.
DR   Ensembl; ENSDART00000031564; ENSDARP00000037070; ENSDARG00000021974.
DR   GeneID; 568747; -.
DR   KEGG; dre:568747; -.
DR   CTD; 119392; -.
DR   ZFIN; ZDB-GENE-070410-27; sfr1.
DR   eggNOG; ENOG502S1QX; Eukaryota.
DR   GeneTree; ENSGT00390000018550; -.
DR   HOGENOM; CLU_075586_1_0_1; -.
DR   InParanoid; B7ZD04; -.
DR   OMA; QPRENPP; -.
DR   OrthoDB; 1628702at2759; -.
DR   PhylomeDB; B7ZD04; -.
DR   TreeFam; TF332725; -.
DR   PRO; PR:B7ZD04; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 13.
DR   Bgee; ENSDARG00000021974; Expressed in testis and 24 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0032798; C:Swi5-Sfr1 complex; ISS:UniProtKB.
DR   GO; GO:0030374; F:nuclear receptor coactivator activity; IBA:GO_Central.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR   InterPro; IPR042429; SFR1.
DR   InterPro; IPR018468; SFR1/Mei5.
DR   PANTHER; PTHR28643; PTHR28643; 1.
DR   Pfam; PF10376; Mei5; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; DNA damage; DNA repair; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..201
FT                   /note="Swi5-dependent recombination DNA repair protein 1
FT                   homolog"
FT                   /id="PRO_0000406977"
FT   REGION          1..111
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          109..131
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..32
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        53..101
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        30
FT                   /note="P -> S (in Ref. 2; AAI33893)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        185
FT                   /note="N -> D (in Ref. 2; AAI33893)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   201 AA;  23066 MW;  25739440AD320360 CRC64;
     METTPIKPTA ADETTPSAEQ SSNRSSTAKP MSASLREKLK RSRHSFKSPL SVVKRLKIED
     DTEPQPSQQG EEEKHGVKDD RDSNVTETDV NRNDMKLQRD SNHTAELPSQ QCEALRKAVK
     ERTETLRRLK MVKMYRKKND LNELQRLTDK WRSCAQSVLY ELQRELATGG KQASLSQLID
     SFGINDKLLH FDRTEEDFTD T