ID   SFR1_RAT                Reviewed;         251 AA.
AC   Q6TXG9;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Swi5-dependent recombination DNA repair protein 1 homolog;
DE   AltName: Full=Liver regeneration-related protein LRRGT00030;
DE   AltName: Full=Meiosis protein 5 homolog;
GN   Name=Sfr1; Synonyms=Mei5, Meir5;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Liver;
RA   Xu C.S., Chang C.F., Han H.P., Wang G.P., Chai L.Q., Yuan J.Y., Yang K.J.,
RA   Zhao L.F., Ma H., Wang L., Wang S.F., Xing X.K., Shen G.M., Shi J.B.,
RA   Rahman S., Wang Q.N., Zhang J.B.;
RT   "Liver regeneration after PH.";
RL   Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the SWI5-SFR1 complex, a complex required for
CC       double-strand break repair via homologous recombination. Acts as a
CC       transcriptional modulator for ESR1. {ECO:0000250|UniProtKB:Q86XK3}.
CC   -!- SUBUNIT: Component of the SWI5-SFR1 complex. Interacts with RAD51; the
CC       interaction is weak (By similarity). Interacts with ESR1 in a ligand-
CC       independent and ligand-dependent manner (By similarity).
CC       {ECO:0000250|UniProtKB:Q86XK3}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8BP27}.
CC   -!- SIMILARITY: Belongs to the SFR1/MEI5 family. {ECO:0000305}.
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DR   EMBL; AY383685; AAQ96243.1; -; mRNA.
DR   AlphaFoldDB; Q6TXG9; -.
DR   SMR; Q6TXG9; -.
DR   STRING; 10116.ENSRNOP00000016881; -.
DR   iPTMnet; Q6TXG9; -.
DR   PhosphoSitePlus; Q6TXG9; -.
DR   jPOST; Q6TXG9; -.
DR   PaxDb; Q6TXG9; -.
DR   PRIDE; Q6TXG9; -.
DR   Ensembl; ENSRNOT00000088962; ENSRNOP00000068947; ENSRNOG00000012641.
DR   UCSC; RGD:1305481; rat.
DR   RGD; 1305481; Sfr1.
DR   eggNOG; ENOG502S1QX; Eukaryota.
DR   GeneTree; ENSGT00390000018550; -.
DR   HOGENOM; CLU_075586_1_0_1; -.
DR   InParanoid; Q6TXG9; -.
DR   PhylomeDB; Q6TXG9; -.
DR   TreeFam; TF332725; -.
DR   PRO; PR:Q6TXG9; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000012641; Expressed in ovary and 20 other tissues.
DR   ExpressionAtlas; Q6TXG9; baseline and differential.
DR   Genevisible; Q6TXG9; RN.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0032798; C:Swi5-Sfr1 complex; ISS:UniProtKB.
DR   GO; GO:0030374; F:nuclear receptor coactivator activity; ISS:UniProtKB.
DR   GO; GO:0071391; P:cellular response to estrogen stimulus; ISO:RGD.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   InterPro; IPR042429; SFR1.
DR   InterPro; IPR018468; SFR1/Mei5.
DR   PANTHER; PTHR28643; PTHR28643; 1.
DR   Pfam; PF10376; Mei5; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; DNA damage; DNA repair; Nucleus; Phosphoprotein;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..251
FT                   /note="Swi5-dependent recombination DNA repair protein 1
FT                   homolog"
FT                   /id="PRO_0000406975"
FT   REGION          88..150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          149..202
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        88..133
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        134..150
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         27
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BP27"
FT   MOD_RES         72
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q86XK3"
SQ   SEQUENCE   251 AA;  28729 MW;  3BE7C8A1E827A64F CRC64;
     MASAPSDIPE NAFRLAKASG RCQSMMSQMK DETKCMGAVF SGYPTALWLE YEVSPQPMSG
     TLKERLKKAR ASSQPFCSVV KRIKVENEEN DQTLSEPGES SKEENCSKAQ ESLENKDNEP
     EKESSEDKNT SESKSLDTGS SSVLQKDSTE KTIKQTLKEE KAKLTRQVQE KEDLLRRLKL
     VKMYRIKNDV TELEDLIKKW RRCGQRLLCE LQSIMSEDED EKLTLTELID YYGIDDKLLH
     YNRTEEEFTG V