ID   SFR1_XENLA              Reviewed;         213 AA.
AC   Q68F53;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Swi5-dependent recombination DNA repair protein 1 homolog;
DE   AltName: Full=Meiosis protein 5 homolog;
GN   Name=sfr1; Synonyms=mei5, meir5;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the swi5-sfr1 complex, a complex required for
CC       double-strand break repair via homologous recombination (By
CC       similarity). {ECO:0000250|UniProtKB:Q86XK3}.
CC   -!- SUBUNIT: Component of the swi5-sfr1 complex.
CC       {ECO:0000250|UniProtKB:Q86XK3}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8BP27}.
CC   -!- SIMILARITY: Belongs to the SFR1/MEI5 family. {ECO:0000305}.
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DR   EMBL; BC079991; AAH79991.1; -; mRNA.
DR   RefSeq; NP_001087482.1; NM_001094013.1.
DR   RefSeq; XP_018080048.1; XM_018224559.1.
DR   AlphaFoldDB; Q68F53; -.
DR   SMR; Q68F53; -.
DR   MaxQB; Q68F53; -.
DR   DNASU; 447306; -.
DR   GeneID; 447306; -.
DR   KEGG; xla:447306; -.
DR   CTD; 447306; -.
DR   Xenbase; XB-GENE-6254016; sfr1.L.
DR   OMA; IDKWRRC; -.
DR   OrthoDB; 1628702at2759; -.
DR   Proteomes; UP000186698; Chromosome 7L.
DR   Bgee; 447306; Expressed in muscle tissue and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0032798; C:Swi5-Sfr1 complex; ISS:UniProtKB.
DR   GO; GO:0030374; F:nuclear receptor coactivator activity; IEA:InterPro.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; ISS:UniProtKB.
DR   InterPro; IPR042429; SFR1.
DR   InterPro; IPR018468; SFR1/Mei5.
DR   PANTHER; PTHR28643; PTHR28643; 1.
DR   Pfam; PF10376; Mei5; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; DNA damage; DNA repair; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..213
FT                   /note="Swi5-dependent recombination DNA repair protein 1
FT                   homolog"
FT                   /id="PRO_0000406978"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          59..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          112..169
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..28
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        65..79
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   213 AA;  24472 MW;  E4B32931E1A66320 CRC64;
     MESTSPHQGS FYKSNLCSPD SPKDTVPKQP MSATLRERLR KTRRSFNAAF SVAKRLKVDC
     EENESSSDCP NNNLPPHEDS EPNATKIEVD LVSEGDICRL DSRTSSEASS PVRCKDHKQL
     LQEKKLLLKK LEEQEDTLRR LKMVKLYRAK NNLSELQSLI EKWRKSSQLS LYELQAALIA
     ENNKVTLSQL IESYGLDENL LHYNRTEEDF QDQ