SFRP1_CHICK
ID SFRP1_CHICK Reviewed; 314 AA.
AC Q9DEQ4;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Secreted frizzled-related protein 1;
DE Short=CsFRP1;
DE Short=sFRP-1;
DE Flags: Precursor;
GN Name=SFRP1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX PubMed=11025229; DOI=10.1016/s0925-4773(00)00421-4;
RA Esteve P., Morcillo J., Bovolenta P.;
RT "Early and dynamic expression of cSfrp1 during chick embryo development.";
RL Mech. Dev. 97:217-221(2000).
CC -!- FUNCTION: Soluble frizzled-related proteins (sFRPS) function as
CC modulators of Wnt signaling through direct interaction with Wnts. They
CC have a role in regulating cell growth and differentiation in specific
CC cell types.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Note=Cell membrane or
CC extracellular matrix-associated. Released by heparin-binding (By
CC similarity). {ECO:0000250}.
CC -!- DEVELOPMENTAL STAGE: Expression first detected at the pre-streak stage,
CC uniformly distributed throughout the blastula. During primitive streak
CC formation, expression localized to the anterior blastoderm including
CC the anterior tip of primitive streak. At the beginning of Hensen node
CC regression, strongly expressed, anterior to the node, in the ectoderm,
CC in the presumptive neuroectoderm as well as in prechordal and lateral
CC mesoderm. Later expression in the blastoderm anterior to Hensen node.
CC During neurulation, high levels detected in the anterior neural plate.
CC Expression also found in the neural folds including the pre-migratory
CC cephalic neural crest cells, in the anterior ectoderm, in the lateral
CC mesoderm, in the precordal plate and weaker expression in the
CC notochord. From stage 10-14, strong expression in the anterior neural
CC tube, including the optic vessels, where expression is limited to the
CC presumptive neural retina and the overlying ectoderm. Later expression
CC in the lens placode and the outer layer of the optic cup. Expression
CC also in the prechordal plate, the Rathke pouch and later in the
CC infundibular region. Expression in head mesenchyme, including migrating
CC cephalic neural crest cells. Restricted expression within the
CC metencephalic vesicle and ventral neural tube. Also expressed in the
CC notochord, the otic vesicles, dorsal mesocardium and the area vasulosa.
CC From stages 18-26, expression found in the telencephalic vesicles, in
CC the epiphysis, in the optic cup, the trigeminal ganglia, and in a band
CC which occupies the basal plate of prosomere one. During neural tube
CC differentiation, expression follows a rosto-caudal gradient. Expression
CC appears in the floor plate and in cells that occupy the medial neural
CC tube. Expression also localized to the mesenchyme of the developing
CC branchial arches, the most distal and ventral portion of the developing
CC limb buds, including the ectodermal apical ridge and to the mesoderm of
CC the developing kidney. {ECO:0000269|PubMed:11025229}.
CC -!- DOMAIN: The FZ domain is involved in binding with Wnt ligands.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the secreted frizzled-related protein (sFRP)
CC family. {ECO:0000305}.
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DR EMBL; AJ404652; CAC15041.1; -; mRNA.
DR AlphaFoldDB; Q9DEQ4; -.
DR SMR; Q9DEQ4; -.
DR STRING; 9031.ENSGALP00000005489; -.
DR MEROPS; I93.002; -.
DR PaxDb; Q9DEQ4; -.
DR VEuPathDB; HostDB:geneid_395237; -.
DR eggNOG; KOG3577; Eukaryota.
DR InParanoid; Q9DEQ4; -.
DR PhylomeDB; Q9DEQ4; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0017147; F:Wnt-protein binding; IBA:GO_Central.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IBA:GO_Central.
DR CDD; cd07443; CRD_SFRP1; 1.
DR Gene3D; 1.10.2000.10; -; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR026559; SFRP1.
DR InterPro; IPR041760; SFRP1_CRD.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR11309; PTHR11309; 1.
DR PANTHER; PTHR11309:SF87; PTHR11309:SF87; 1.
DR Pfam; PF01392; Fz; 1.
DR Pfam; PF01759; NTR; 1.
DR SMART; SM00643; C345C; 1.
DR SMART; SM00063; FRI; 1.
DR SUPFAM; SSF50242; SSF50242; 1.
DR SUPFAM; SSF63501; SSF63501; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50189; NTR; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; Disulfide bond; Glycoprotein;
KW Reference proteome; Secreted; Signal; Wnt signaling pathway.
FT SIGNAL 1..31
FT /evidence="ECO:0000255"
FT CHAIN 32..314
FT /note="Secreted frizzled-related protein 1"
FT /id="PRO_0000032540"
FT DOMAIN 53..169
FT /note="FZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00090"
FT DOMAIN 186..306
FT /note="NTR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00295"
FT CARBOHYD 173
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 58..121
FT /evidence="ECO:0000250"
FT DISULFID 68..114
FT /evidence="ECO:0000250"
FT DISULFID 105..140
FT /evidence="ECO:0000250"
FT DISULFID 129..166
FT /evidence="ECO:0000250"
FT DISULFID 133..157
FT /evidence="ECO:0000250"
FT DISULFID 186..256
FT /evidence="ECO:0000250"
FT DISULFID 189..258
FT /evidence="ECO:0000250"
FT DISULFID 203..306
FT /evidence="ECO:0000250"
SQ SEQUENCE 314 AA; 35280 MW; A7AE6F9F6F5D333C CRC64;
MGVGRSEGGR RGAALGVLLA LGVALLAVGS ASEYDYVSYQ SDLGPYPGGR FYTKPHQCVA
IPADLRLCHS VGYDKMVLPN LLDHETMAEV KHQASSWVPL LNKNCHMGTQ VFLCSLFAPV
CLDRPVYPCR WLCEAVRDSC EPVMQFFGFF WPEMLKCDQF PQDYVCIAMT TPNATEVSRP
KGTTVCPPCD NEMKSEAIVE HLCASEFALK MTIKEVKKEN GDKVIIPRKR KALKLGPIRK
KNLKKLVLLL KNGADCPCHQ LDNLGHHFLI MGRQVKTQHL LTAIYKWDKK NKEFKKFMKK
VKAPDCPTFP SVFK
