SFRP2_CHICK
ID SFRP2_CHICK Reviewed; 292 AA.
AC Q9IA96;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Secreted frizzled-related protein 2;
DE Short=sFRP-2;
DE Flags: Precursor;
GN Name=SFRP2;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC TISSUE=Embryo;
RX PubMed=10656762; DOI=10.1006/dbio.1999.9586;
RA Ladher R.K., Church V.L., Allen S., Robson L., Abdelfattah A., Brown N.A.,
RA Hattersley G., Rosen V., Luyten F.P., Dale L., Francis-West P.H.;
RT "Cloning and expression of the Wnt antagonists Sfrp-2 and Frzb during chick
RT development.";
RL Dev. Biol. 218:183-198(2000).
CC -!- FUNCTION: Soluble frizzled-related proteins (sFRPS) function as
CC modulators of Wnt signaling through direct interaction with Wnts. They
CC have a role in regulating cell growth and differentiation in specific
CC cell types. SFRP2 appears to be associated with myogenesis.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- DEVELOPMENTAL STAGE: In embryo, expressed in developing neural
CC structures as well as in heart, branchial arches and limb buds. First
CC expressed at stage 7 in the neural plate with lower expression in the
CC midline. By stage 9, expressed through out the developing neural tube
CC with lower levels in the future posterior mesencephalon and rhombomere
CC 3. In anterior regions, highest expression in the dorsal neural tube
CC and, more posteriorly throughout the closing neural tube. Also
CC expressed in the ectoderm flanking the neural tube. In the developing
CC brain, expression found in the presumptive forbrain. By stage 12,
CC expression restricted to the dorsal prosencephalon, hindbrain and
CC posterior neural tube. In the placodes, first expressed at stage 11, in
CC the otic placode. By stage 15, expressed in the olfactory and
CC epibranchial placodes. In facial primordia, expression found at stage
CC 2,0 throughout the ectoderm. By stage 24, high mesenchymal expression
CC in a small region of the posterior maxillary primordia, and in the
CC lateral region of the mandibular primordia. By stage 28, expressed in a
CC subset of muscles, including the intermandibularis muscle and the
CC muscle medial to the eye. In the developing trunk, expression found
CC throughout the dermamyotome in the more developed somites. By stage 20,
CC expression restricted to the small region in the dorsal medial lip in
CC all somites. In addition, also expressed in the ventral lateral lip of
CC the dermamyotome that gives rise to the muscles of the limbs and body
CC wall. During limb development, expressed between stages 20 and 30, in
CC the proximal mesenchyme in association with developing muscles. Between
CC stages 27 and 30, expression found in mesenchyme containing
CC undifferentiated myogenic cells. In the developing heart, expression
CC restricted to the myocardial and endocardial cell layers of the
CC trabeculae in the ventricular compartment between stages 20 and 28.
CC {ECO:0000269|PubMed:10656762}.
CC -!- DOMAIN: The FZ domain is involved in binding with Wnt ligands.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the secreted frizzled-related protein (sFRP)
CC family. {ECO:0000305}.
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DR EMBL; AF218056; AAF27642.1; -; mRNA.
DR RefSeq; NP_990104.1; NM_204773.1.
DR AlphaFoldDB; Q9IA96; -.
DR SMR; Q9IA96; -.
DR STRING; 9031.ENSGALP00000015022; -.
DR MEROPS; I93.002; -.
DR PaxDb; Q9IA96; -.
DR GeneID; 395546; -.
DR KEGG; gga:395546; -.
DR CTD; 6423; -.
DR VEuPathDB; HostDB:geneid_395546; -.
DR eggNOG; KOG3577; Eukaryota.
DR InParanoid; Q9IA96; -.
DR OrthoDB; 1306779at2759; -.
DR PhylomeDB; Q9IA96; -.
DR PRO; PR:Q9IA96; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0017147; F:Wnt-protein binding; IBA:GO_Central.
DR GO; GO:0006915; P:apoptotic process; TAS:AgBase.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IBA:GO_Central.
DR CDD; cd07446; CRD_SFRP2; 1.
DR Gene3D; 1.10.2000.10; -; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR026558; SFRP2.
DR InterPro; IPR041764; SFRP2_CRD.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR11309; PTHR11309; 1.
DR PANTHER; PTHR11309:SF45; PTHR11309:SF45; 1.
DR Pfam; PF01392; Fz; 1.
DR Pfam; PF01759; NTR; 1.
DR SMART; SM00643; C345C; 1.
DR SMART; SM00063; FRI; 1.
DR SUPFAM; SSF50242; SSF50242; 1.
DR SUPFAM; SSF63501; SSF63501; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50189; NTR; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; Disulfide bond; Reference proteome;
KW Secreted; Signal; Wnt signaling pathway.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..292
FT /note="Secreted frizzled-related protein 2"
FT /id="PRO_0000032544"
FT DOMAIN 32..152
FT /note="FZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00090"
FT DOMAIN 169..292
FT /note="NTR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00295"
FT DISULFID 37..100
FT /evidence="ECO:0000250"
FT DISULFID 47..93
FT /evidence="ECO:0000250"
FT DISULFID 84..122
FT /evidence="ECO:0000250"
FT DISULFID 111..149
FT /evidence="ECO:0000250"
FT DISULFID 115..139
FT /evidence="ECO:0000250"
FT DISULFID 169..242
FT /evidence="ECO:0000250"
FT DISULFID 187..292
FT /evidence="ECO:0000250"
SQ SEQUENCE 292 AA; 33119 MW; 0490657229F475B1 CRC64;
MPRRLCALLL LASQCLGSTA GLFPFGEPDF SYKRSNCKPI PAPMLLCRGI EYQSMRLPNL
LGHETVQEVL EQATTWIPLV QKQCHPDTRK FLCSLFAPVC IDDLDEIIQP CHSLCEEVKE
SCAPVMSAFG FPWPDMLDCS RFPKDNDLCI PLASSDHILP VTREAPKVCD ACKNKNEDDN
DIMENLCKND FALKIKVKEI AYINGDTKIT PETKSKTIYK LNGLTERDLR KIVLWLKGGL
QCTCDEMNDI NVPYLVMGQK QAGELVITSL KRWQKGQRAF KRFSRSIRKL QC
