SFRP3_BOVIN
ID SFRP3_BOVIN Reviewed; 325 AA.
AC Q95117; Q2KHY0;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Secreted frizzled-related protein 3;
DE Short=sFRP-3;
DE AltName: Full=Frizzled-related protein 1;
DE AltName: Full=FrzB-1;
DE Flags: Precursor;
GN Name=FRZB; Synonyms=FRZB1, SFRP3;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Cartilage;
RX PubMed=8824257; DOI=10.1074/jbc.271.42.26131;
RA Hoang B., Moos M. Jr., Vukicevic S., Luyten F.P.;
RT "Primary structure and tissue distribution of FRZB, a novel protein related
RT to Drosophila frizzled, suggest a role in skeletal morphogenesis.";
RL J. Biol. Chem. 271:26131-26137(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Kidney;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP INTERACTION OF THE FZ DOMAIN WITH WNT PROTEINS.
RX PubMed=9326585; DOI=10.1073/pnas.94.21.11196;
RA Lin K., Wang S., Julius M.A., Kitajewski J., Moos M. Jr., Luyten F.P.;
RT "The cysteine-rich frizzled domain of Frzb-1 is required and sufficient for
RT modulation of Wnt signaling.";
RL Proc. Natl. Acad. Sci. U.S.A. 94:11196-11200(1997).
CC -!- FUNCTION: Soluble frizzled-related proteins (sFRPS) function as
CC modulators of Wnt signaling through direct interaction with Wnts. They
CC have a role in regulating cell growth and differentiation in specific
CC cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis.
CC Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long
CC bone development.
CC -!- SUBUNIT: Interacts with MYOC. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- DOMAIN: The FZ domain is involved in binding with Wnt ligands.
CC -!- SIMILARITY: Belongs to the secreted frizzled-related protein (sFRP)
CC family. {ECO:0000305}.
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DR EMBL; U24164; AAC48662.1; -; mRNA.
DR EMBL; BC112842; AAI12843.1; -; mRNA.
DR RefSeq; NP_776484.1; NM_174059.2.
DR RefSeq; XP_005202312.1; XM_005202255.3.
DR RefSeq; XP_005202313.1; XM_005202256.3.
DR RefSeq; XP_015330109.1; XM_015474623.1.
DR AlphaFoldDB; Q95117; -.
DR SMR; Q95117; -.
DR STRING; 9913.ENSBTAP00000014572; -.
DR PaxDb; Q95117; -.
DR PRIDE; Q95117; -.
DR Ensembl; ENSBTAT00000014572; ENSBTAP00000014572; ENSBTAG00000010977.
DR GeneID; 281170; -.
DR KEGG; bta:281170; -.
DR CTD; 2487; -.
DR VEuPathDB; HostDB:ENSBTAG00000010977; -.
DR VGNC; VGNC:29124; FRZB.
DR eggNOG; KOG3577; Eukaryota.
DR GeneTree; ENSGT00940000160494; -.
DR HOGENOM; CLU_058446_1_0_1; -.
DR InParanoid; Q95117; -.
DR OMA; CNELPLY; -.
DR OrthoDB; 1339129at2759; -.
DR Proteomes; UP000009136; Chromosome 2.
DR Bgee; ENSBTAG00000010977; Expressed in retina and 100 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0017147; F:Wnt-protein binding; ISS:AgBase.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
DR GO; GO:0090103; P:cochlea morphogenesis; IEA:Ensembl.
DR GO; GO:0060029; P:convergent extension involved in organogenesis; IEA:Ensembl.
DR GO; GO:0002064; P:epithelial cell development; IEA:Ensembl.
DR GO; GO:0070365; P:hepatocyte differentiation; IEA:Ensembl.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IBA:GO_Central.
DR GO; GO:0061037; P:negative regulation of cartilage development; IEA:Ensembl.
DR GO; GO:0010721; P:negative regulation of cell development; IEA:Ensembl.
DR GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0070367; P:negative regulation of hepatocyte differentiation; IEA:Ensembl.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; ISS:AgBase.
DR GO; GO:0014033; P:neural crest cell differentiation; IEA:Ensembl.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0045600; P:positive regulation of fat cell differentiation; IEA:Ensembl.
DR GO; GO:0061053; P:somite development; IEA:Ensembl.
DR CDD; cd07441; CRD_SFRP3; 1.
DR CDD; cd03581; NTR_Sfrp3_like; 1.
DR Gene3D; 1.10.2000.10; -; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR035813; NTR_Sfrp3.
DR InterPro; IPR026556; SFRP3.
DR InterPro; IPR041759; SFRP3_CRD.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR11309; PTHR11309; 1.
DR PANTHER; PTHR11309:SF97; PTHR11309:SF97; 1.
DR Pfam; PF01392; Fz; 1.
DR Pfam; PF01759; NTR; 1.
DR SMART; SM00643; C345C; 1.
DR SMART; SM00063; FRI; 1.
DR SUPFAM; SSF50242; SSF50242; 1.
DR SUPFAM; SSF63501; SSF63501; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50189; NTR; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Differentiation; Disulfide bond; Glycoprotein;
KW Reference proteome; Secreted; Signal; Wnt signaling pathway.
FT SIGNAL 1..32
FT /evidence="ECO:0000255"
FT CHAIN 33..325
FT /note="Secreted frizzled-related protein 3"
FT /id="PRO_0000032545"
FT DOMAIN 33..150
FT /note="FZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00090"
FT DOMAIN 178..298
FT /note="NTR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00295"
FT REGION 299..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 49
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 299
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 35..96
FT /evidence="ECO:0000250"
FT DISULFID 43..89
FT /evidence="ECO:0000250"
FT DISULFID 80..119
FT /evidence="ECO:0000250"
FT DISULFID 108..147
FT /evidence="ECO:0000250"
FT DISULFID 112..136
FT /evidence="ECO:0000250"
SQ SEQUENCE 325 AA; 36234 MW; 39E337A9C6E98BB3 CRC64;
MVCGSRGGML LLPAGLLALA ALCLLRVPGA RAAACEPVRI PLCKSLPWNM TKMPNHLHHS
TQANAILAIE QFEGLLGTHC SPDLLFFLCA MYAPICTIDF QHEPIKPCKS VCERARQGCE
PILIKYRHSW PESLACEELP VYDRGVCISP EAIVTADGAD FPMDSSNGNC RGASSERCKC
KPVRATQKTY FRNNYNYVIR AKVKEIKTKC HDVTAVVEVK EILKASLVNI PRETVNLYTS
SGCLCPPLNV NEEYLIMGYE DEERSRLLLV EGSIAEKWKD RLGKKVKRWD MKLRHLGLNT
SDSSHSDSTQ SQKPGRNSNS RQARN
