SFRP5_BOVIN
ID SFRP5_BOVIN Reviewed; 315 AA.
AC Q9XSC1; A6QP61;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Secreted frizzled-related protein 5;
DE Short=sFRP-5;
DE Flags: Precursor;
GN Name=SFRP5;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Retinal pigment epithelium;
RX PubMed=10072424; DOI=10.1093/hmg/8.4.575;
RA Chang J.T., Esumi N., Moore K., Li Y., Zhang S., Chew C., Goodman B.,
RA Rattner A., Moody S., Stetten G., Campochiaro P.A., Zack D.J.;
RT "Cloning and characterization of a secreted frizzled-related protein that
RT is expressed by the retinal pigment epithelium.";
RL Hum. Mol. Genet. 8:575-583(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal skin;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Soluble frizzled-related proteins (sFRPS) function as
CC modulators of Wnt signaling through direct interaction with Wnts. They
CC have a role in regulating cell growth and differentiation in specific
CC cell types. SFRP5 may be involved in determining the polarity of
CC photoreceptor, and perhaps other, cells in the retina. Inhibits Wnt8
CC signaling, in vitro.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Strongly expressed in the retinal pigment
CC epithelium (RPE). Weak expression in retina, brain, heart, liver,
CC kidney, testis and muscle. {ECO:0000269|PubMed:10072424}.
CC -!- DOMAIN: The FZ domain is involved in binding with Wnt ligands.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the secreted frizzled-related protein (sFRP)
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF117757; AAD25051.1; -; mRNA.
DR EMBL; BC149165; AAI49166.1; -; mRNA.
DR RefSeq; NP_776886.1; NM_174461.2.
DR AlphaFoldDB; Q9XSC1; -.
DR SMR; Q9XSC1; -.
DR STRING; 9913.ENSBTAP00000024709; -.
DR MEROPS; I93.002; -.
DR PaxDb; Q9XSC1; -.
DR Ensembl; ENSBTAT00000024709; ENSBTAP00000024709; ENSBTAG00000018566.
DR GeneID; 282069; -.
DR KEGG; bta:282069; -.
DR CTD; 6425; -.
DR VEuPathDB; HostDB:ENSBTAG00000018566; -.
DR VGNC; VGNC:34523; SFRP5.
DR eggNOG; KOG3577; Eukaryota.
DR GeneTree; ENSGT00940000160608; -.
DR HOGENOM; CLU_054647_1_0_1; -.
DR InParanoid; Q9XSC1; -.
DR OMA; PEMLHCG; -.
DR OrthoDB; 1306779at2759; -.
DR TreeFam; TF350133; -.
DR Proteomes; UP000009136; Chromosome 26.
DR Bgee; ENSBTAG00000018566; Expressed in bone marrow and 90 other tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0017147; F:Wnt-protein binding; IBA:GO_Central.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IBA:GO_Central.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0043433; P:negative regulation of DNA-binding transcription factor activity; IEA:Ensembl.
DR GO; GO:0051898; P:negative regulation of protein kinase B signaling; IEA:Ensembl.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IDA:BHF-UCL.
DR GO; GO:2000057; P:negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis; IEA:Ensembl.
DR GO; GO:0030510; P:regulation of BMP signaling pathway; IEA:InterPro.
DR CDD; cd07444; CRD_SFRP5; 1.
DR Gene3D; 1.10.2000.10; -; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR034860; SFRP-5.
DR InterPro; IPR041761; SFRP5_CRD.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR11309; PTHR11309; 1.
DR PANTHER; PTHR11309:SF46; PTHR11309:SF46; 1.
DR Pfam; PF01392; Fz; 1.
DR Pfam; PF01759; NTR; 1.
DR SMART; SM00643; C345C; 1.
DR SMART; SM00063; FRI; 1.
DR SUPFAM; SSF50242; SSF50242; 1.
DR SUPFAM; SSF63501; SSF63501; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50189; NTR; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; Disulfide bond; Reference proteome;
KW Secreted; Signal; Wnt signaling pathway.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..315
FT /note="Secreted frizzled-related protein 5"
FT /id="PRO_0000032554"
FT DOMAIN 46..163
FT /note="FZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00090"
FT DOMAIN 179..301
FT /note="NTR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00295"
FT DISULFID 51..114
FT /evidence="ECO:0000250"
FT DISULFID 61..107
FT /evidence="ECO:0000250"
FT DISULFID 98..133
FT /evidence="ECO:0000250"
FT DISULFID 122..160
FT /evidence="ECO:0000250"
FT DISULFID 126..150
FT /evidence="ECO:0000250"
FT DISULFID 179..251
FT /evidence="ECO:0000250"
FT DISULFID 182..253
FT /evidence="ECO:0000250"
FT DISULFID 196..301
FT /evidence="ECO:0000250"
SQ SEQUENCE 315 AA; 35279 MW; 8B6E94951060A976 CRC64;
MRAAAGGARA AVLALLLGAL HGAPARGEEY DYYGWQTEPL HGRSYSKPPQ CLDIPADLPL
CHTVGYKRMR LPNLLEHESL AEVKQQASSW LPLLAKRCHS DTQVFLCSLF APVCLDRPIY
PCRSLCEAVR AGCAPLMEAY GFPWPEMLHC HKFPLDNDLC IAVQFGHLPA TAPPVTKICA
QCEMEHSADG LMEQMCSSDF VVKMRIKEIK IENGDRKLIG AQKKKKLLKS GPLKRKDTKR
LVLHMKNSAG CPCPQLDSLA GSFLVMGRKV DGQLLLMAVY RWDKKNKEMK FAVKFMFSYP
CSLYYPFFYG AAEPH
