ID   SFR_ENCCU               Reviewed;         301 AA.
AC   Q8SRU2;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Probable splicing factor ECU05_1440;
DE   AltName: Full=Pre-mRNA-splicing factor ECU05_1440;
GN   OrderedLocusNames=ECU05_1440;
OS   Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=284813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1;
RX   PubMed=11719806; DOI=10.1038/35106579;
RA   Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA   Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA   Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA   Vivares C.P.;
RT   "Genome sequence and gene compaction of the eukaryote parasite
RT   Encephalitozoon cuniculi.";
RL   Nature 414:450-453(2001).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], AND
RP   DEVELOPMENTAL STAGE.
RX   PubMed=16691553; DOI=10.1002/pmic.200500796;
RA   Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.;
RT   "Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi
RT   (microsporidia): a reference map for proteins expressed in late sporogonial
RT   stages.";
RL   Proteomics 6:3625-3635(2006).
CC   -!- FUNCTION: Plays a role in splicing. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in late sporogonial stages.
CC       {ECO:0000269|PubMed:16691553}.
CC   -!- SIMILARITY: Belongs to the splicing factor SR family. {ECO:0000305}.
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DR   EMBL; AL590445; CAD26664.1; -; Genomic_DNA.
DR   RefSeq; NP_597487.1; NM_001041353.1.
DR   AlphaFoldDB; Q8SRU2; -.
DR   STRING; 284813.Q8SRU2; -.
DR   PRIDE; Q8SRU2; -.
DR   GeneID; 859154; -.
DR   KEGG; ecu:ECU05_1440; -.
DR   VEuPathDB; MicrosporidiaDB:ECU05_1440; -.
DR   HOGENOM; CLU_940185_0_0_1; -.
DR   InParanoid; Q8SRU2; -.
DR   OMA; WNESIID; -.
DR   OrthoDB; 1315388at2759; -.
DR   Proteomes; UP000000819; Chromosome V.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   1: Evidence at protein level;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat;
KW   RNA-binding.
FT   CHAIN           1..301
FT                   /note="Probable splicing factor ECU05_1440"
FT                   /id="PRO_0000383122"
FT   DOMAIN          1..70
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          182..255
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          106..140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          255..301
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        114..140
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        255..274
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   301 AA;  34854 MW;  DC845033257D9AC8 CRC64;
     MQIFIGKIPN HVSEEQIKEY FGQFGEVTDV SLKGTYGFLN FDSEGSITRV LNQRTHSIDG
     APISVERANG RKRPLDGEYH DRYMDMGRGG YSPHRDYRGF RNAPYPPMRY ESRSPGRYDP
     RFSDRYGGRS PEYRGDSFRM GDPQRSRDFC EYCNACPIHG MRDMMDSRKR HHMSRDHPNN
     HLKVVFENIA PNTAIEDFKN FVQDHGFEPS YARLGYSGNH AVFEFKNIED KDNAMKKLDG
     AEFNGHILKT RSYLSKDEYK SRERESHMRS ELQPTDNGEA EPQGTTTDIY EGIEDAKAEN
     D