SFT1_YEAST
ID SFT1_YEAST Reviewed; 97 AA.
AC P43682; D6VXT0;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Protein transport protein SFT1;
DE AltName: Full=P14;
GN Name=SFT1; OrderedLocusNames=YKL006C-A; ORFNames=YKL006BC;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8488728; DOI=10.1002/yea.320090307;
RA Boyer J., Pascolo S., Richard G.-F., Dujon B.;
RT "Sequence of a 7.8 kb segment on the left arm of yeast chromosome XI
RT reveals four open reading frames, including the CAP1 gene, an intron-
RT containing gene and a gene encoding a homolog to the mammalian UOG-1
RT gene.";
RL Yeast 9:279-287(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8196765; DOI=10.1038/369371a0;
RA Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V.,
RA Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P.,
RA Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L.,
RA Daignan-Fornier B., del Rey F., Dion C., Domdey H., Duesterhoeft A.,
RA Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H.,
RA Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L.,
RA Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M.,
RA Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H.,
RA Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J.,
RA Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H.,
RA Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J.,
RA Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S.,
RA Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F.,
RA Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R.,
RA Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W.,
RA Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M.,
RA Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C.,
RA Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H.,
RA Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L.,
RA van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S.,
RA von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M.,
RA Becker I., Mewes H.-W.;
RT "Complete DNA sequence of yeast chromosome XI.";
RL Nature 369:371-378(1994).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=7596416; DOI=10.1038/375806a0;
RA Banfield D.K., Lewis M.J., Pelham H.R.B.;
RT "A SNARE-like protein required for traffic through the Golgi complex.";
RL Nature 375:806-809(1995).
RN [5]
RP FUNCTION, AND INTERACTION WITH SED5; GOS1 AND YKT6.
RX PubMed=11001058; DOI=10.1038/35025076;
RA Parlati F., McNew J.A., Fukuda R., Miller R., Sollner T.H., Rothman J.E.;
RT "Topological restriction of SNARE-dependent membrane fusion.";
RL Nature 407:194-198(2000).
RN [6]
RP FUNCTION.
RX PubMed=15229219; DOI=10.1074/jbc.m405500200;
RA Bruinsma P., Spelbrink R.G., Nothwehr S.F.;
RT "Retrograde transport of the mannosyltransferase Och1p to the early Golgi
RT requires a component of the COG transport complex.";
RL J. Biol. Chem. 279:39814-39823(2004).
CC -!- FUNCTION: Vesicle SNARE required for retrograde transport within the
CC Golgi complex. {ECO:0000269|PubMed:11001058,
CC ECO:0000269|PubMed:15229219, ECO:0000269|PubMed:7596416}.
CC -!- SUBUNIT: Component of a SNARE complex consisting of SED5, GOS1, YKT6
CC and SFT1.
CC -!- INTERACTION:
CC P43682; Q01590: SED5; NbExp=2; IntAct=EBI-17040, EBI-16930;
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000269|PubMed:7596416}; Single-pass type IV membrane protein
CC {ECO:0000269|PubMed:7596416}.
CC -!- MISCELLANEOUS: Multicopy suppressor of sed5-1.
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DR EMBL; Z28006; CAA81840.1; -; Genomic_DNA.
DR EMBL; Z28007; CAA81842.1; -; Genomic_DNA.
DR EMBL; BK006944; DAA09150.1; -; Genomic_DNA.
DR PIR; S58405; S58405.
DR RefSeq; NP_012919.3; NM_001180028.3.
DR AlphaFoldDB; P43682; -.
DR SMR; P43682; -.
DR BioGRID; 34126; 38.
DR ComplexPortal; CPX-1855; Golgi SNARE complex SED5-GOS1-SFT1-YKT6.
DR DIP; DIP-4355N; -.
DR IntAct; P43682; 5.
DR MINT; P43682; -.
DR STRING; 4932.YKL006C-A; -.
DR iPTMnet; P43682; -.
DR MaxQB; P43682; -.
DR PaxDb; P43682; -.
DR PRIDE; P43682; -.
DR EnsemblFungi; YKL006C-A_mRNA; YKL006C-A; YKL006C-A.
DR GeneID; 853863; -.
DR KEGG; sce:YKL006C-A; -.
DR SGD; S000002101; SFT1.
DR VEuPathDB; FungiDB:YKL006C-A; -.
DR eggNOG; ENOG502S4UD; Eukaryota.
DR HOGENOM; CLU_150783_1_0_1; -.
DR InParanoid; P43682; -.
DR OMA; NIWRMVG; -.
DR BioCyc; YEAST:G3O-32070-MON; -.
DR Reactome; R-SCE-6807878; COPI-mediated anterograde transport.
DR Reactome; R-SCE-6811438; Intra-Golgi traffic.
DR PRO; PR:P43682; -.
DR Proteomes; UP000002311; Chromosome XI.
DR RNAct; P43682; protein.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IC:ComplexPortal.
DR GO; GO:1990674; C:Golgi cis cisterna membrane; IC:ComplexPortal.
DR GO; GO:0000138; C:Golgi trans cisterna; IDA:SGD.
DR GO; GO:0030173; C:integral component of Golgi membrane; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IDA:ComplexPortal.
DR GO; GO:0031201; C:SNARE complex; IDA:SGD.
DR GO; GO:0005484; F:SNAP receptor activity; IDA:SGD.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IDA:ComplexPortal.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IMP:SGD.
DR GO; GO:0006886; P:intracellular protein transport; IDA:ComplexPortal.
DR GO; GO:0006906; P:vesicle fusion; IDA:SGD.
DR GO; GO:0048280; P:vesicle fusion with Golgi apparatus; IC:ComplexPortal.
DR CDD; cd15853; SNARE_Bet1; 1.
DR InterPro; IPR039897; BET1.
DR InterPro; IPR039899; BET1_SNARE.
DR InterPro; IPR000727; T_SNARE_dom.
DR PANTHER; PTHR12791; PTHR12791; 1.
DR SMART; SM00397; t_SNARE; 1.
DR PROSITE; PS50192; T_SNARE; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Golgi apparatus; Membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..97
FT /note="Protein transport protein SFT1"
FT /id="PRO_0000097712"
FT TOPO_DOM 1..74
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..94
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 95..97
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT DOMAIN 7..69
FT /note="t-SNARE coiled-coil homology"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00202"
SQ SEQUENCE 97 AA; 10961 MW; 69BC0B64E9A77C07 CRC64;
MSNSRYSQTE SNNDRKLEGL ANKLATFRNI NQEIGDRAVS DSSVINQMTD SLGSMFTDIK
NSSSRLTRSL KAGNSIWRMV GLALLIFFIL YTLFKLF
