SFT2A_HUMAN
ID SFT2A_HUMAN Reviewed; 159 AA.
AC Q8WV19; Q5TI64; Q9UIC7;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Vesicle transport protein SFT2A;
DE AltName: Full=SFT2 domain-containing protein 1;
DE AltName: Full=pRGR1;
GN Name=SFT2D1 {ECO:0000312|EMBL:AAH18969.1}; Synonyms=C6orf83;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1] {ECO:0000312|EMBL:AAF18564.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Hu Y.F., Mao X.H., Zhuang M., Lu C.D.;
RL Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [3] {ECO:0000312|EMBL:AAH18969.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Choriocarcinoma;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: May be involved in fusion of retrograde transport vesicles
CC derived from an endocytic compartment with the Golgi complex.
CC {ECO:0000250|UniProtKB:P38166}.
CC -!- INTERACTION:
CC Q8WV19; Q13520: AQP6; NbExp=3; IntAct=EBI-2854842, EBI-13059134;
CC Q8WV19; P53367: ARFIP1; NbExp=3; IntAct=EBI-2854842, EBI-2808808;
CC Q8WV19; Q5T4B2: CERCAM; NbExp=3; IntAct=EBI-2854842, EBI-12261896;
CC Q8WV19; Q9GZP9: DERL2; NbExp=3; IntAct=EBI-2854842, EBI-7962814;
CC Q8WV19; Q9NR28: DIABLO; NbExp=3; IntAct=EBI-2854842, EBI-517508;
CC Q8WV19; Q08426: EHHADH; NbExp=3; IntAct=EBI-2854842, EBI-2339219;
CC Q8WV19; Q96C03-3: MIEF2; NbExp=3; IntAct=EBI-2854842, EBI-11988931;
CC Q8WV19; P26927: MST1; NbExp=3; IntAct=EBI-2854842, EBI-6929133;
CC Q8WV19; Q9HB07: MYG1; NbExp=3; IntAct=EBI-2854842, EBI-709754;
CC Q8WV19; Q9ULP0-2: NDRG4; NbExp=3; IntAct=EBI-2854842, EBI-11978907;
CC Q8WV19; Q96BN8: OTULIN; NbExp=3; IntAct=EBI-2854842, EBI-750730;
CC Q8WV19; Q96CS7: PLEKHB2; NbExp=3; IntAct=EBI-2854842, EBI-373552;
CC Q8WV19; Q96T60: PNKP; NbExp=3; IntAct=EBI-2854842, EBI-1045072;
CC Q8WV19; Q9H6H4: REEP4; NbExp=3; IntAct=EBI-2854842, EBI-7545592;
CC Q8WV19; Q86VR2: RETREG3; NbExp=3; IntAct=EBI-2854842, EBI-10192441;
CC Q8WV19; P57086: SCAND1; NbExp=3; IntAct=EBI-2854842, EBI-745846;
CC Q8WV19; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-2854842, EBI-17247926;
CC Q8WV19; O00560: SDCBP; NbExp=3; IntAct=EBI-2854842, EBI-727004;
CC Q8WV19; Q14973: SLC10A1; NbExp=3; IntAct=EBI-2854842, EBI-3923031;
CC Q8WV19; Q8IWU4: SLC30A8; NbExp=3; IntAct=EBI-2854842, EBI-10262251;
CC Q8WV19; Q13596: SNX1; NbExp=3; IntAct=EBI-2854842, EBI-2822329;
CC Q8WV19; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-2854842, EBI-742688;
CC Q8WV19; P27105: STOM; NbExp=3; IntAct=EBI-2854842, EBI-1211440;
CC Q8WV19; Q17RD7: SYT16; NbExp=3; IntAct=EBI-2854842, EBI-10238936;
CC Q8WV19; Q9BW92: TARS2; NbExp=3; IntAct=EBI-2854842, EBI-1045099;
CC Q8WV19; Q969Z0: TBRG4; NbExp=3; IntAct=EBI-2854842, EBI-702328;
CC Q8WV19; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-2854842, EBI-8638294;
CC Q8WV19; Q8WV15: TMEM255B; NbExp=3; IntAct=EBI-2854842, EBI-2870087;
CC Q8WV19; Q8N661: TMEM86B; NbExp=3; IntAct=EBI-2854842, EBI-2548832;
CC Q8WV19; Q9Y320: TMX2; NbExp=3; IntAct=EBI-2854842, EBI-6447886;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the SFT2 family. {ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF18564.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF041429; AAF18564.1; ALT_INIT; mRNA.
DR EMBL; AL022069; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL121956; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC018969; AAH18969.1; -; mRNA.
DR CCDS; CCDS5292.1; -.
DR RefSeq; NP_660152.1; NM_145169.2.
DR AlphaFoldDB; Q8WV19; -.
DR BioGRID; 125243; 45.
DR IntAct; Q8WV19; 34.
DR MINT; Q8WV19; -.
DR STRING; 9606.ENSP00000354590; -.
DR iPTMnet; Q8WV19; -.
DR PhosphoSitePlus; Q8WV19; -.
DR SwissPalm; Q8WV19; -.
DR BioMuta; SFT2D1; -.
DR DMDM; 74751535; -.
DR EPD; Q8WV19; -.
DR jPOST; Q8WV19; -.
DR MassIVE; Q8WV19; -.
DR MaxQB; Q8WV19; -.
DR PaxDb; Q8WV19; -.
DR PeptideAtlas; Q8WV19; -.
DR PRIDE; Q8WV19; -.
DR ProteomicsDB; 74737; -.
DR Antibodypedia; 20056; 14 antibodies from 11 providers.
DR DNASU; 113402; -.
DR Ensembl; ENST00000361731.4; ENSP00000354590.3; ENSG00000198818.10.
DR GeneID; 113402; -.
DR KEGG; hsa:113402; -.
DR MANE-Select; ENST00000361731.4; ENSP00000354590.3; NM_145169.3; NP_660152.1.
DR UCSC; uc003qux.4; human.
DR CTD; 113402; -.
DR GeneCards; SFT2D1; -.
DR HGNC; HGNC:21102; SFT2D1.
DR HPA; ENSG00000198818; Low tissue specificity.
DR neXtProt; NX_Q8WV19; -.
DR OpenTargets; ENSG00000198818; -.
DR PharmGKB; PA134962126; -.
DR VEuPathDB; HostDB:ENSG00000198818; -.
DR eggNOG; KOG2887; Eukaryota.
DR GeneTree; ENSGT00390000018525; -.
DR HOGENOM; CLU_099529_2_2_1; -.
DR InParanoid; Q8WV19; -.
DR OMA; IKCFSSC; -.
DR OrthoDB; 1476123at2759; -.
DR PhylomeDB; Q8WV19; -.
DR TreeFam; TF315157; -.
DR PathwayCommons; Q8WV19; -.
DR SignaLink; Q8WV19; -.
DR BioGRID-ORCS; 113402; 8 hits in 1080 CRISPR screens.
DR ChiTaRS; SFT2D1; human.
DR GenomeRNAi; 113402; -.
DR Pharos; Q8WV19; Tdark.
DR PRO; PR:Q8WV19; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q8WV19; protein.
DR Bgee; ENSG00000198818; Expressed in epithelial cell of pancreas and 186 other tissues.
DR Genevisible; Q8WV19; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR InterPro; IPR007305; Vesicle_transpt_Got1/SFT2.
DR InterPro; IPR011691; Vesicle_transpt_SFT2.
DR PANTHER; PTHR23137; PTHR23137; 1.
DR Pfam; PF04178; Got1; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Protein transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..159
FT /note="Vesicle transport protein SFT2A"
FT /id="PRO_0000238607"
FT TOPO_DOM 1..36
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 37..57
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 58..62
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..83
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 84..97
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..122
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..143
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 144..159
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 9
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5SSN7"
FT VARIANT 109
FT /note="I -> V (in dbSNP:rs11551053)"
FT /id="VAR_034492"
FT CONFLICT 93
FT /note="F -> C (in Ref. 1; AAF18564)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 159 AA; 17804 MW; 0EC8A9CED7EF27E0 CRC64;
MEKLRRVLSG QDDEEQGLTA QVLDASSLSF NTRLKWFAIC FVCGVFFSIL GTGLLWLPGG
IKLFAVFYTL GNLAALASTC FLMGPVKQLK KMFEATRLLA TIVMLLCFIF TLCAALWWHK
KGLAVLFCIL QFLSMTWYSL SYIPYARDAV IKCCSSLLS
