SFT2A_RAT
ID SFT2A_RAT Reviewed; 159 AA.
AC Q5U3Y5;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Vesicle transport protein SFT2A;
DE AltName: Full=SFT2 domain-containing protein 1;
GN Name=Sft2d1 {ECO:0000250|UniProtKB:Q8WV19};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in fusion of retrograde transport vesicles
CC derived from an endocytic compartment with the Golgi complex.
CC {ECO:0000250|UniProtKB:P38166}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the SFT2 family. {ECO:0000255}.
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DR EMBL; BC085346; AAH85346.1; -; mRNA.
DR RefSeq; NP_001008303.1; NM_001008302.1.
DR AlphaFoldDB; Q5U3Y5; -.
DR STRING; 10116.ENSRNOP00000042831; -.
DR PaxDb; Q5U3Y5; -.
DR GeneID; 292305; -.
DR KEGG; rno:292305; -.
DR CTD; 113402; -.
DR RGD; 1359119; Sft2d1.
DR VEuPathDB; HostDB:ENSRNOG00000024140; -.
DR eggNOG; KOG2887; Eukaryota.
DR HOGENOM; CLU_099529_2_2_1; -.
DR InParanoid; Q5U3Y5; -.
DR OMA; IKCFSSC; -.
DR OrthoDB; 1476123at2759; -.
DR PhylomeDB; Q5U3Y5; -.
DR TreeFam; TF315157; -.
DR PRO; PR:Q5U3Y5; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000024140; Expressed in spleen and 20 other tissues.
DR Genevisible; Q5U3Y5; RN.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR InterPro; IPR007305; Vesicle_transpt_Got1/SFT2.
DR InterPro; IPR011691; Vesicle_transpt_SFT2.
DR PANTHER; PTHR23137; PTHR23137; 1.
DR Pfam; PF04178; Got1; 1.
PE 2: Evidence at transcript level;
KW Membrane; Phosphoprotein; Protein transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..159
FT /note="Vesicle transport protein SFT2A"
FT /id="PRO_0000238609"
FT TOPO_DOM 1..36
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 37..57
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 58..62
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..83
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 84..97
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..122
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..143
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 144..159
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 9
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5SSN7"
SQ SEQUENCE 159 AA; 17887 MW; 07FBF7CBD1A11D3C CRC64;
MEKLRRVLSG QDDEEQGLTA QVLDASSLSF NTRLKWFVIC FVAGIFFSIL GTGLLWLPNG
VKLFAVFYTL GNLAALASTC FLMGPVKQLK KMFETTRLLA TIIMLLCLVF TLCAALWWRK
KGLALLFCIL QFLSMTWYSL SYIPYARDAV LKCCSSILS
