SFT2C_MOUSE
ID SFT2C_MOUSE Reviewed; 212 AA.
AC Q9CSV6; E9QJT3;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-OCT-2019, sequence version 3.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Vesicle transport protein SFT2C;
DE AltName: Full=SFT2 domain-containing protein 3;
GN Name=Sft2d3 {ECO:0000312|MGI:MGI:1914408};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2] {ECO:0000312|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000312|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May be involved in fusion of retrograde transport vesicles
CC derived from an endocytic compartment with the Golgi complex.
CC {ECO:0000250|UniProtKB:P38166}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the SFT2 family. {ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB27904.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK011898; BAB27904.1; ALT_FRAME; mRNA.
DR EMBL; AC131761; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS50243.1; -.
DR RefSeq; NP_080282.1; NM_026006.1.
DR AlphaFoldDB; Q9CSV6; -.
DR STRING; 10090.ENSMUSP00000100656; -.
DR iPTMnet; Q9CSV6; -.
DR PhosphoSitePlus; Q9CSV6; -.
DR SwissPalm; Q9CSV6; -.
DR MaxQB; Q9CSV6; -.
DR PaxDb; Q9CSV6; -.
DR PeptideAtlas; Q9CSV6; -.
DR PRIDE; Q9CSV6; -.
DR ProteomicsDB; 261199; -.
DR ProteomicsDB; 357448; -.
DR Antibodypedia; 47566; 111 antibodies from 21 providers.
DR Ensembl; ENSMUST00000054984; ENSMUSP00000100656; ENSMUSG00000044982.
DR GeneID; 67158; -.
DR KEGG; mmu:67158; -.
DR CTD; 84826; -.
DR MGI; MGI:1914408; Sft2d3.
DR VEuPathDB; HostDB:ENSMUSG00000044982; -.
DR eggNOG; ENOG502QV5D; Eukaryota.
DR GeneTree; ENSGT00390000018525; -.
DR HOGENOM; CLU_099529_3_1_1; -.
DR InParanoid; Q9CSV6; -.
DR OMA; SGFSWPW; -.
DR OrthoDB; 1371944at2759; -.
DR PhylomeDB; Q9CSV6; -.
DR TreeFam; TF313609; -.
DR BioGRID-ORCS; 67158; 0 hits in 73 CRISPR screens.
DR ChiTaRS; Sft2d3; mouse.
DR PRO; PR:Q9CSV6; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q9CSV6; protein.
DR Bgee; ENSMUSG00000044982; Expressed in otolith organ and 185 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR InterPro; IPR007305; Vesicle_transpt_Got1/SFT2.
DR InterPro; IPR011691; Vesicle_transpt_SFT2.
DR PANTHER; PTHR23137; PTHR23137; 1.
DR Pfam; PF04178; Got1; 1.
PE 1: Evidence at protein level;
KW Membrane; Protein transport; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..212
FT /note="Vesicle transport protein SFT2C"
FT /id="PRO_0000238614"
FT TOPO_DOM 1..78
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 100..104
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 126..142
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..165
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 166..174
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..197
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 198..212
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 17..19
FT /note="Missing (in Ref. 1; BAB27904)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 212 AA; 21949 MW; 2B58AABCBBA55CFA CRC64;
MADLHRQLQD YLKQGKASRP AAAEPLLGAK AAEEPEAGAW LGSRVLRWPW AQSAAEPPPA
GLRCLPSVTR GQRLVAGGLC LLLAALCFGL AALYAPVLLL RARKFALLWS LGSVLAWASA
ALLRGGPACG RLLRGEETPS RSTLGYAAAL GATLYAALVL RSTVLTALGA CAQVAALLYA
LIGLLPWGGV TALRLALGRL NRGTGLANAL PV
