SFTA2_HUMAN
ID SFTA2_HUMAN Reviewed; 78 AA.
AC Q6UW10; A2ABK7; A2ACH1; B7ZCJ7;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Surfactant-associated protein 2;
DE AltName: Full=Surfactant-associated protein G;
DE Short=SP-G;
DE Flags: Precursor;
GN Name=SFTA2; Synonyms=SFTPG; ORFNames=UNQ541/PRO1098;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PROTEIN SEQUENCE OF 20-34.
RX PubMed=15340161; DOI=10.1110/ps.04682504;
RA Zhang Z., Henzel W.J.;
RT "Signal peptide prediction based on analysis of experimentally verified
RT cleavage sites.";
RL Protein Sci. 13:2819-2824(2004).
RN [6]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND GLYCOSYLATION.
RX PubMed=22768197; DOI=10.1371/journal.pone.0040011;
RA Mittal R.A., Hammel M., Schwarz J., Heschl K.M., Bretschneider N.,
RA Flemmer A.W., Herber-Jonat S., Koenigshoff M., Eickelberg O., Holzinger A.;
RT "SFTA2--a novel secretory peptide highly expressed in the lung--is
RT modulated by lipopolysaccharide but not hyperoxia.";
RL PLoS ONE 7:E40011-E40011(2012).
CC -!- FUNCTION: Putative surfactant protein. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:22768197}.
CC Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:22768197}.
CC Golgi apparatus {ECO:0000269|PubMed:22768197}.
CC -!- TISSUE SPECIFICITY: Predominantly expressed in lung, where it is
CC detected in type II pneumocytes in the alveolus, and in nonciliated
CC epithelium in bronchioli (at protein level). Also detected at lower
CC levels in cervix, esophagus, stomach, testis and kidney.
CC {ECO:0000269|PubMed:22768197}.
CC -!- PTM: N-glycosylated. {ECO:0000269|PubMed:22768197}.
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DR EMBL; AY359057; AAQ89416.1; -; mRNA.
DR EMBL; AL773541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL662854; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL669830; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759747; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX927194; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR936875; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471081; EAX03350.1; -; Genomic_DNA.
DR EMBL; BC039677; AAH39677.1; -; mRNA.
DR CCDS; CCDS4691.1; -.
DR RefSeq; NP_995326.1; NM_205854.2.
DR AlphaFoldDB; Q6UW10; -.
DR BioGRID; 133117; 46.
DR IntAct; Q6UW10; 8.
DR STRING; 9606.ENSP00000351989; -.
DR GlyGen; Q6UW10; 1 site.
DR iPTMnet; Q6UW10; -.
DR PhosphoSitePlus; Q6UW10; -.
DR BioMuta; SFTA2; -.
DR MassIVE; Q6UW10; -.
DR PaxDb; Q6UW10; -.
DR PeptideAtlas; Q6UW10; -.
DR PRIDE; Q6UW10; -.
DR Antibodypedia; 82321; 1 antibodies from 1 providers.
DR DNASU; 389376; -.
DR Ensembl; ENST00000359086.4; ENSP00000351989.3; ENSG00000196260.5.
DR Ensembl; ENST00000383539.4; ENSP00000373031.4; ENSG00000206465.4.
DR Ensembl; ENST00000429290.2; ENSP00000390291.2; ENSG00000230072.2.
DR Ensembl; ENST00000454649.2; ENSP00000398777.2; ENSG00000237814.2.
DR Ensembl; ENST00000457919.2; ENSP00000407762.2; ENSG00000225454.2.
DR GeneID; 389376; -.
DR KEGG; hsa:389376; -.
DR MANE-Select; ENST00000359086.4; ENSP00000351989.3; NM_205854.3; NP_995326.1.
DR UCSC; uc003nsf.4; human.
DR CTD; 389376; -.
DR DisGeNET; 389376; -.
DR GeneCards; SFTA2; -.
DR HGNC; HGNC:18386; SFTA2.
DR HPA; ENSG00000196260; Group enriched (esophagus, lung).
DR neXtProt; NX_Q6UW10; -.
DR OpenTargets; ENSG00000196260; -.
DR PharmGKB; PA164725669; -.
DR VEuPathDB; HostDB:ENSG00000196260; -.
DR eggNOG; ENOG502TGNM; Eukaryota.
DR GeneTree; ENSGT00390000011767; -.
DR HOGENOM; CLU_173432_0_0_1; -.
DR InParanoid; Q6UW10; -.
DR OMA; SPHHVTC; -.
DR PhylomeDB; Q6UW10; -.
DR TreeFam; TF354134; -.
DR PathwayCommons; Q6UW10; -.
DR SignaLink; Q6UW10; -.
DR BioGRID-ORCS; 389376; 58 hits in 1062 CRISPR screens.
DR GenomeRNAi; 389376; -.
DR Pharos; Q6UW10; Tdark.
DR PRO; PR:Q6UW10; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q6UW10; protein.
DR Bgee; ENSG00000196260; Expressed in right lung and 85 other tissues.
DR ExpressionAtlas; Q6UW10; baseline and differential.
DR Genevisible; Q6UW10; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
DR InterPro; IPR028198; SFTA2.
DR PANTHER; PTHR38500; PTHR38500; 1.
DR Pfam; PF15210; SFTA2; 1.
PE 1: Evidence at protein level;
KW Cytoplasmic vesicle; Direct protein sequencing; Glycoprotein;
KW Golgi apparatus; Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000269|PubMed:15340161"
FT CHAIN 20..78
FT /note="Surfactant-associated protein 2"
FT /id="PRO_0000022610"
FT CARBOHYD 37
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 37
FT /note="N -> S (in dbSNP:rs3131787)"
FT /id="VAR_034423"
SQ SEQUENCE 78 AA; 8396 MW; 4470CEE55D025483 CRC64;
MGSGLPLVLL LTLLGSSHGT GPGMTLQLKL KESFLTNSSY ESSFLELLEK LCLLLHLPSG
TSVTLHHARS QHHVVCNT
