ID   SFTA2_MOUSE             Reviewed;          77 AA.
AC   E9PXB6;
DT   06-JUL-2016, integrated into UniProtKB/Swiss-Prot.
DT   05-APR-2011, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Surfactant-associated protein 2 {ECO:0000312|MGI:MGI:3643293};
DE   AltName: Full=Surfactant-associated protein G {ECO:0000250|UniProtKB:Q6UW10};
DE   Flags: Precursor;
GN   Name=Sfta2 {ECO:0000312|MGI:MGI:3643293};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000312|Proteomes:UP000000589};
RN   [1] {ECO:0000312|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000312|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000305}
RP   TISSUE SPECIFICITY, AND INDUCTION BY LPS.
RX   PubMed=22768197; DOI=10.1371/journal.pone.0040011;
RA   Mittal R.A., Hammel M., Schwarz J., Heschl K.M., Bretschneider N.,
RA   Flemmer A.W., Herber-Jonat S., Koenigshoff M., Eickelberg O., Holzinger A.;
RT   "SFTA2--a novel secretory peptide highly expressed in the lung--is
RT   modulated by lipopolysaccharide but not hyperoxia.";
RL   PLoS ONE 7:E40011-E40011(2012).
CC   -!- FUNCTION: Putative surfactant protein. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Cytoplasmic vesicle,
CC       secretory vesicle {ECO:0000250|UniProtKB:Q6UW10}. Golgi apparatus
CC       {ECO:0000250|UniProtKB:Q6UW10}.
CC   -!- TISSUE SPECIFICITY: Expressed in lung, and specifically in alveolar
CC       type II epithelial cells. {ECO:0000269|PubMed:22768197}.
CC   -!- INDUCTION: Down-regulated in response to LPS (lipopolysaccharide)
CC       challenge. {ECO:0000269|PubMed:22768197}.
CC   -!- PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q6UW10}.
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DR   EMBL; CR974473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS50093.1; -.
DR   RefSeq; NP_001156666.1; NM_001163194.1.
DR   AlphaFoldDB; E9PXB6; -.
DR   SMR; E9PXB6; -.
DR   STRING; 10090.ENSMUSP00000132839; -.
DR   GlyGen; E9PXB6; 1 site.
DR   PhosphoSitePlus; E9PXB6; -.
DR   PaxDb; E9PXB6; -.
DR   PRIDE; E9PXB6; -.
DR   Ensembl; ENSMUST00000171166; ENSMUSP00000132839; ENSMUSG00000090509.
DR   GeneID; 433102; -.
DR   KEGG; mmu:433102; -.
DR   UCSC; uc008cid.1; mouse.
DR   CTD; 389376; -.
DR   MGI; MGI:3643293; Sfta2.
DR   VEuPathDB; HostDB:ENSMUSG00000090509; -.
DR   eggNOG; ENOG502TGNM; Eukaryota.
DR   HOGENOM; CLU_173432_0_0_1; -.
DR   OMA; SPHHVTC; -.
DR   OrthoDB; 1635321at2759; -.
DR   BioGRID-ORCS; 433102; 0 hits in 68 CRISPR screens.
DR   ChiTaRS; Sfta2; mouse.
DR   PRO; PR:E9PXB6; -.
DR   Proteomes; UP000000589; Chromosome 17.
DR   RNAct; E9PXB6; protein.
DR   Bgee; ENSMUSG00000090509; Expressed in lung and 20 other tissues.
DR   ExpressionAtlas; E9PXB6; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
DR   InterPro; IPR028198; SFTA2.
DR   PANTHER; PTHR38500; PTHR38500; 1.
DR   Pfam; PF15210; SFTA2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle; Glycoprotein; Golgi apparatus; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..77
FT                   /note="Surfactant-associated protein 2"
FT                   /id="PRO_5003245479"
FT   CARBOHYD        61
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   77 AA;  8502 MW;  AC131EDDF35E779F CRC64;
     MESLMRLFLL LALLSSSHAG PKVTLQVKLT ETFQDKTSQN SSALDMLQKI CLLLHLPSGT
     NVTLLHKGPP HYLTCRA