SFTA3_HUMAN
ID SFTA3_HUMAN Reviewed; 94 AA.
AC P0C7M3;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 1.
DT 03-AUG-2022, entry version 75.
DE RecName: Full=Surfactant-associated protein 3;
DE AltName: Full=Surfactant-associated protein H;
DE Short=SP-H;
GN Name=SFTA3; Synonyms=SFTPH;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY, INDUCTION, AND SUBCELLULAR LOCATION.
RX PubMed=24743970; DOI=10.1183/09031936.00179813;
RA Schicht M., Rausch F., Finotto S., Mathews M., Mattil A., Schubert M.,
RA Koch B., Traxdorf M., Bohr C., Worlitzsch D., Brandt W., Garreis F.,
RA Sel S., Paulsen F., Brauer L.;
RT "SFTA3, a novel protein of the lung: three-dimensional structure,
RT characterisation and immune activation.";
RL Eur. Respir. J. 44:447-456(2014).
RN [4]
RP TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND PUTATIVE FUNCTION.
RX PubMed=29955092; DOI=10.1038/s41598-018-28005-9;
RA Schicht M., Garreis F., Hartjen N., Beileke S., Jacobi C., Sahin A.,
RA Holland D., Schroeder H., Hammer C.M., Paulsen F., Braeuer L.;
RT "SFTA3 - a novel surfactant protein of the ocular surface and its role in
RT corneal wound healing and tear film surface tension.";
RL Sci. Rep. 8:9791-9791(2018).
CC -!- FUNCTION: Putative surfactant protein. May be involved in wound healing
CC and in the reduction of the surface tension at the ocular surface.
CC {ECO:0000269|PubMed:29955092}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24743970,
CC ECO:0000269|PubMed:29955092}. Secreted {ECO:0000269|PubMed:24743970,
CC ECO:0000269|PubMed:29955092}.
CC -!- TISSUE SPECIFICITY: Found in lung alveolar cells type I and II, as well
CC as alveolar macrophages (at protein level). Detected also in testis and
CC kidney. Expressed by different tissues of the ocular system like
CC cornea, conjuctiva, lacrimal gland, eyelid and efferent tear ducts (at
CC protein level). From these tissues is secreted into the tear film (at
CC protein level) (PubMed:29955092). {ECO:0000269|PubMed:24743970,
CC ECO:0000269|PubMed:29955092}.
CC -!- INDUCTION: By lipopolysaccharides (LPS). Down-regulated by cytokines
CC IL1B; TNF and IL23 (PubMed:24743970, PubMed:29955092). Up-regulated in
CC tears from patients suffering from different forms of dry eye disease
CC (DED) (PubMed:29955092). {ECO:0000269|PubMed:24743970,
CC ECO:0000269|PubMed:29955092}.
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DR EMBL; AL132857; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC042093; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_001094811.1; NM_001101341.1.
DR AlphaFoldDB; P0C7M3; -.
DR STRING; 9606.ENSP00000428331; -.
DR BioMuta; SFTA3; -.
DR PaxDb; P0C7M3; -.
DR PRIDE; P0C7M3; -.
DR UCSC; uc001wtr.4; human.
DR GeneCards; SFTA3; -.
DR HGNC; HGNC:18387; SFTA3.
DR MalaCards; SFTA3; -.
DR MIM; 617860; gene.
DR neXtProt; NX_P0C7M3; -.
DR PharmGKB; PA164725680; -.
DR eggNOG; ENOG502TEQ8; Eukaryota.
DR HOGENOM; CLU_2399139_0_0_1; -.
DR InParanoid; P0C7M3; -.
DR OrthoDB; 1515208at2759; -.
DR PathwayCommons; P0C7M3; -.
DR Reactome; R-HSA-5683826; Surfactant metabolism.
DR Reactome; R-HSA-5688849; Defective CSF2RB causes SMDP5.
DR Reactome; R-HSA-5688890; Defective CSF2RA causes SMDP4.
DR SignaLink; P0C7M3; -.
DR BioGRID-ORCS; 253970; 9 hits in 1060 CRISPR screens.
DR ChiTaRS; SFTA3; human.
DR GenomeRNAi; 253970; -.
DR Pharos; P0C7M3; Tbio.
DR PRO; PR:P0C7M3; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; P0C7M3; protein.
DR Genevisible; P0C7M3; HS.
DR GO; GO:0045334; C:clathrin-coated endocytic vesicle; TAS:Reactome.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR GO; GO:0042599; C:lamellar body; TAS:Reactome.
DR GO; GO:0042060; P:wound healing; IMP:UniProtKB.
PE 1: Evidence at protein level;
KW Cytoplasm; Reference proteome; Secreted.
FT CHAIN 1..94
FT /note="Surfactant-associated protein 3"
FT /id="PRO_0000339370"
SQ SEQUENCE 94 AA; 10526 MW; 1387FD89206AF571 CRC64;
MRAGFSDFQL IRDQVLFLQD QAQRLTEWLQ LSGFENPVSE STTLCLRERE KRIPTCVAVC
VPSPGTVHTA LLHPTTLSQS RSSSEAKMLI IHTA
