SFXN1_DROME
ID SFXN1_DROME Reviewed; 321 AA.
AC Q9VN13;
DT 13-FEB-2019, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Sideroflexin-1-3 {ECO:0000305};
GN Name=Sfxn1-3 {ECO:0000312|FlyBase:FBgn0037239};
GN ORFNames=CG11739 {ECO:0000312|FlyBase:FBgn0037239};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Testis;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M.,
RA Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.,
RA Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., Miranda A.,
RA Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., Patel S.,
RA Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S.;
RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=30442778; DOI=10.1126/science.aat9528;
RA Kory N., Wyant G.A., Prakash G., Uit de Bos J., Bottanelli F., Pacold M.E.,
RA Chan S.H., Lewis C.A., Wang T., Keys H.R., Guo Y.E., Sabatini D.M.;
RT "SFXN1 is a mitochondrial serine transporter required for one-carbon
RT metabolism.";
RL Science 362:0-0(2018).
CC -!- FUNCTION: Mitochondrial amino-acid transporter that mediates transport
CC of serine into mitochondria. {ECO:0000269|PubMed:30442778}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC {ECO:0000269|PubMed:30442778}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the sideroflexin family. {ECO:0000305}.
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DR EMBL; AE014297; AAF52138.3; -; Genomic_DNA.
DR EMBL; AE014297; AAN13307.2; -; Genomic_DNA.
DR EMBL; AE014297; AAN13308.2; -; Genomic_DNA.
DR EMBL; AE014297; AAN13309.2; -; Genomic_DNA.
DR EMBL; AY089419; AAL90157.1; -; mRNA.
DR EMBL; BT001832; AAN71587.1; -; mRNA.
DR RefSeq; NP_649460.3; NM_141203.4.
DR RefSeq; NP_730821.2; NM_164345.3.
DR RefSeq; NP_730822.2; NM_164346.3.
DR RefSeq; NP_730823.2; NM_164347.3.
DR AlphaFoldDB; Q9VN13; -.
DR IntAct; Q9VN13; 2.
DR STRING; 7227.FBpp0078553; -.
DR PaxDb; Q9VN13; -.
DR PRIDE; Q9VN13; -.
DR DNASU; 40552; -.
DR EnsemblMetazoa; FBtr0078913; FBpp0078553; FBgn0037239.
DR EnsemblMetazoa; FBtr0078914; FBpp0078554; FBgn0037239.
DR EnsemblMetazoa; FBtr0078915; FBpp0078555; FBgn0037239.
DR EnsemblMetazoa; FBtr0078916; FBpp0078556; FBgn0037239.
DR GeneID; 40552; -.
DR KEGG; dme:Dmel_CG11739; -.
DR UCSC; CG11739-RA; d. melanogaster.
DR CTD; 40552; -.
DR FlyBase; FBgn0037239; Sfxn1-3.
DR VEuPathDB; VectorBase:FBgn0037239; -.
DR eggNOG; KOG3767; Eukaryota.
DR GeneTree; ENSGT01030000234641; -.
DR HOGENOM; CLU_039425_1_0_1; -.
DR InParanoid; Q9VN13; -.
DR OMA; GRVRHCA; -.
DR OrthoDB; 881974at2759; -.
DR PhylomeDB; Q9VN13; -.
DR BioGRID-ORCS; 40552; 0 hits in 3 CRISPR screens.
DR ChiTaRS; Sfxn1-3; fly.
DR GenomeRNAi; 40552; -.
DR PRO; PR:Q9VN13; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0037239; Expressed in embryonic/larval hemocyte (Drosophila) and 23 other tissues.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IDA:UniProtKB.
DR GO; GO:0022889; F:serine transmembrane transporter activity; IDA:UniProtKB.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:1990542; P:mitochondrial transmembrane transport; IDA:UniProtKB.
DR GO; GO:0006730; P:one-carbon metabolic process; IDA:UniProtKB.
DR GO; GO:0140300; P:serine import into mitochondrion; IDA:UniProtKB.
DR InterPro; IPR004686; Mtc.
DR PANTHER; PTHR11153; PTHR11153; 1.
DR Pfam; PF03820; SFXNs; 1.
DR TIGRFAMs; TIGR00798; mtc; 1.
PE 2: Evidence at transcript level;
KW Amino-acid transport; Membrane; Mitochondrion; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..321
FT /note="Sideroflexin-1-3"
FT /id="PRO_0000446381"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 220..240
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..286
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 321 AA; 35744 MW; 8858874FBC4B706D CRC64;
MSPLPRVNID EPKYDQNSYL GRAKHFFLLT NPLNVLASAS KLEEARQIVI KYRAGKDVPE
CKTIDDVWRA KYLYDSAFHP ETGEKQIVIG RMAAQMPMNT IITGGMMAFY KSTPAVVFWQ
WFNQTFNAIV NYTNRSGTSP ISQQQLVTSY CLATSGALVT ALSLNHAVKN MNPLLGRLVP
LVAVGAANCI NIPCMRMQEL RNGVTLFDEH SNEMGISKKA AVVGISTVIL SRIAMAIPGM
TLTPVLMNVL EKRGFLAKYP RSNAPIQTLF CGFVLIFATP LGCAFFKQRA DIKVDSLESE
VRDSIRKKRP ELETVWFNKG L
