ID   SFXN2_BOVIN             Reviewed;         322 AA.
AC   Q5EA43;
DT   22-AUG-2006, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 2.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Sideroflexin-2 {ECO:0000250|UniProtKB:Q96NB2};
GN   Name=SFXN2 {ECO:0000250|UniProtKB:Q96NB2};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
CC   -!- FUNCTION: Mitochondrial amino-acid transporter that mediates transport
CC       of serine into mitochondria (By similarity). Involved in mitochondrial
CC       iron homeostasis by regulating heme biosynthesis (By similarity).
CC       {ECO:0000250|UniProtKB:Q96NB2}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-serine(in) = L-serine(out); Xref=Rhea:RHEA:35031,
CC         ChEBI:CHEBI:33384; Evidence={ECO:0000250|UniProtKB:Q96NB2};
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q96NB2}; Multi-pass membrane protein
CC       {ECO:0000255}. Mitochondrion outer membrane
CC       {ECO:0000250|UniProtKB:Q96NB2}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the sideroflexin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAX08743.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BT020726; AAX08743.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001029618.1; NM_001034446.1.
DR   RefSeq; XP_005225575.1; XM_005225518.3.
DR   RefSeq; XP_005225576.1; XM_005225519.2.
DR   RefSeq; XP_005225577.1; XM_005225520.2.
DR   RefSeq; XP_015316146.1; XM_015460660.1.
DR   RefSeq; XP_015316147.1; XM_015460661.1.
DR   AlphaFoldDB; Q5EA43; -.
DR   STRING; 9913.ENSBTAP00000005659; -.
DR   PaxDb; Q5EA43; -.
DR   GeneID; 513450; -.
DR   KEGG; bta:513450; -.
DR   CTD; 118980; -.
DR   eggNOG; KOG3767; Eukaryota.
DR   HOGENOM; CLU_039425_1_0_1; -.
DR   InParanoid; Q5EA43; -.
DR   TreeFam; TF313205; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0022889; F:serine transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:1990542; P:mitochondrial transmembrane transport; ISS:UniProtKB.
DR   GO; GO:0140300; P:serine import into mitochondrion; IBA:GO_Central.
DR   InterPro; IPR004686; Mtc.
DR   PANTHER; PTHR11153; PTHR11153; 1.
DR   Pfam; PF03820; SFXNs; 1.
DR   TIGRFAMs; TIGR00798; mtc; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Amino-acid transport; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Mitochondrion outer membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..322
FT                   /note="Sideroflexin-2"
FT                   /id="PRO_0000247975"
FT   TRANSMEM        100..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        228..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        265..287
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96NB2"
SQ   SEQUENCE   322 AA;  36302 MW;  575CC22C2BC9A004 CRC64;
     MEADLSDFNI DAPRWDQCTF LGRVKHFFNI TDPRTVLVPE RELDWAKVMV EQSRMGTVPP
     GTQVEQLFYA KKLYDSAFHP DTGHKMNVIG RMSFQVPGGM IITGFMLQFY RTMPAVIFWQ
     WVNQSFNALV NYTNRNAASP TSVRQMAVSY ITATTTAVAT AVGMNMLTKR APPLVGRWVP
     FAAVAAANCV NIPMMRQQEL IQGICVKDRN HNEIGHSRRA AAIGITQVVI SRITMAAPGM
     ILLPVLMERL EKLRFVQRVR VLHAPLQVLL SGCFLIFMVP VACGLFPQQC ELPVSYLEPE
     LQDTIKAKYR EPVPHVYFNK GL