ID   SFXN3_BOVIN             Reviewed;         321 AA.
AC   A6QP55;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Sideroflexin-3;
GN   Name=SFXN3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mitochondrial serine transporter that mediates transport of
CC       serine into mitochondria, an important step of the one-carbon
CC       metabolism pathway. Mitochondrial serine is converted to glycine and
CC       formate, which then exits to the cytosol where it is used to generate
CC       the charged folates that serve as one-carbon donors.
CC       {ECO:0000250|UniProtKB:Q9BWM7}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-serine(in) = L-serine(out); Xref=Rhea:RHEA:35031,
CC         ChEBI:CHEBI:33384; Evidence={ECO:0000250|UniProtKB:Q9BWM7};
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC       {ECO:0000250|UniProtKB:Q9BWM7}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the sideroflexin family. {ECO:0000305}.
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DR   EMBL; BC149158; AAI49159.1; -; mRNA.
DR   RefSeq; NP_001095416.1; NM_001101946.1.
DR   AlphaFoldDB; A6QP55; -.
DR   BioGRID; 168386; 1.
DR   STRING; 9913.ENSBTAP00000006601; -.
DR   PaxDb; A6QP55; -.
DR   PRIDE; A6QP55; -.
DR   Ensembl; ENSBTAT00000006601; ENSBTAP00000006601; ENSBTAG00000005015.
DR   GeneID; 511755; -.
DR   KEGG; bta:511755; -.
DR   CTD; 81855; -.
DR   VEuPathDB; HostDB:ENSBTAG00000005015; -.
DR   VGNC; VGNC:34532; SFXN3.
DR   eggNOG; KOG3767; Eukaryota.
DR   GeneTree; ENSGT01030000234641; -.
DR   HOGENOM; CLU_039425_1_0_1; -.
DR   InParanoid; A6QP55; -.
DR   OMA; STPICCA; -.
DR   OrthoDB; 881974at2759; -.
DR   TreeFam; TF313205; -.
DR   Proteomes; UP000009136; Chromosome 26.
DR   Bgee; ENSBTAG00000005015; Expressed in retina and 105 other tissues.
DR   ExpressionAtlas; A6QP55; baseline and differential.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0022889; F:serine transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:1990542; P:mitochondrial transmembrane transport; ISS:UniProtKB.
DR   GO; GO:0006730; P:one-carbon metabolic process; ISS:UniProtKB.
DR   GO; GO:0140300; P:serine import into mitochondrion; ISS:UniProtKB.
DR   InterPro; IPR004686; Mtc.
DR   PANTHER; PTHR11153; PTHR11153; 1.
DR   Pfam; PF03820; SFXNs; 1.
DR   TIGRFAMs; TIGR00798; mtc; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Amino-acid transport; Membrane; Mitochondrion;
KW   One-carbon metabolism; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..321
FT                   /note="Sideroflexin-3"
FT                   /id="PRO_0000350612"
FT   TRANSMEM        146..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        226..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        266..286
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BWM7"
SQ   SEQUENCE   321 AA;  35708 MW;  A629379B08EBD712 CRC64;
     MGELPLDINI QEPRWDQRTF LGRARHFFTV TDPRNLLLSG AQLEASRNIV QNYRAGIVTP
     GLTEDQLWRA KYVYDSAFHP DTGEKVVLIG RMSAQVPMNM TITGCMLIFY RKTPTVVFWQ
     WLNQSFNAVV NYSNRSGDAP ITVRQLGMAY VSATTGAVAT ALGLKSLTKH LPPLVGRFVP
     FAAVAAANCI NIPLMRQREL QVGIPVTNEQ GQRLGHSVAA AKKGIFQVVI SRICMAIPAM
     AIPPVIMDTL EKKDFLKRRP WLGAPLQMGL VGFCLVFATP LCCALFPQRS SIHVSRLEPE
     LRAQIQEQNP SIEVVYYNKG L