ID   SFXN3_PONAB             Reviewed;         321 AA.
AC   Q5RD16;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Sideroflexin-3;
GN   Name=SFXN3;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mitochondrial serine transporter that mediates transport of
CC       serine into mitochondria, an important step of the one-carbon
CC       metabolism pathway. Mitochondrial serine is converted to glycine and
CC       formate, which then exits to the cytosol where it is used to generate
CC       the charged folates that serve as one-carbon donors.
CC       {ECO:0000250|UniProtKB:Q9BWM7}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-serine(in) = L-serine(out); Xref=Rhea:RHEA:35031,
CC         ChEBI:CHEBI:33384; Evidence={ECO:0000250|UniProtKB:Q9BWM7};
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC       {ECO:0000250|UniProtKB:Q9BWM7}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the sideroflexin family. {ECO:0000305}.
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DR   EMBL; CR858102; CAH90341.1; -; mRNA.
DR   RefSeq; NP_001125163.1; NM_001131691.1.
DR   AlphaFoldDB; Q5RD16; -.
DR   STRING; 9601.ENSPPYP00000002997; -.
DR   GeneID; 100172050; -.
DR   KEGG; pon:100172050; -.
DR   CTD; 81855; -.
DR   eggNOG; KOG3767; Eukaryota.
DR   InParanoid; Q5RD16; -.
DR   OrthoDB; 881974at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0022889; F:serine transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:1990542; P:mitochondrial transmembrane transport; ISS:UniProtKB.
DR   GO; GO:0006730; P:one-carbon metabolic process; ISS:UniProtKB.
DR   GO; GO:0140300; P:serine import into mitochondrion; ISS:UniProtKB.
DR   InterPro; IPR004686; Mtc.
DR   PANTHER; PTHR11153; PTHR11153; 1.
DR   Pfam; PF03820; SFXNs; 1.
DR   TIGRFAMs; TIGR00798; mtc; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Amino-acid transport; Membrane; Mitochondrion;
KW   One-carbon metabolism; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..321
FT                   /note="Sideroflexin-3"
FT                   /id="PRO_0000177039"
FT   TRANSMEM        146..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        226..246
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        266..286
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BWM7"
SQ   SEQUENCE   321 AA;  35517 MW;  546C7F2BFAD234BD CRC64;
     MGELPLDINI QEPRWDQSTF LGRARHFFTV TDPRNLLLSG AQLEASRNIV QNYRAGVVTP
     GITEDQLWRA KYVYDSAFHP DTGEKVVLIG RMSAQVPMNM TITGCMLTFY RKTPTVVFWQ
     WVNQSFNAIV NYSNRSGDTP ITVRQLGTAY VSATTGAVAT ALGLKSLTKH LPPLVGRFVP
     FAAVAAANCI NIPLMRQREL QVGIPVADEA GQRLGYSVTA AKQGIFQVVI SRICMAIPAM
     AIPPLIMDTL EKKDFLKRRP WLGAPLQVGL VGFCLVFATP LCCALFPQKS SIHVSKLEPE
     LRAQIHEQNP SIEVVYYNKG L