ID   SFXN4_BOVIN             Reviewed;         313 AA.
AC   Q3T0M2;
DT   22-AUG-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Sideroflexin-4 {ECO:0000305};
GN   Name=SFXN4 {ECO:0000250|UniProtKB:Q9H9B4};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mitochondrial amino-acid transporter (By similarity). Does
CC       not act as a serine transporter: not able to mediate transport of
CC       serine into mitochondria (By similarity).
CC       {ECO:0000250|UniProtKB:Q6P4A7, ECO:0000250|UniProtKB:Q9H9B4}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q6P4A7}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the sideroflexin family. {ECO:0000305}.
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DR   EMBL; BC102332; AAI02333.1; -; mRNA.
DR   RefSeq; NP_001030232.1; NM_001035060.2.
DR   AlphaFoldDB; Q3T0M2; -.
DR   STRING; 9913.ENSBTAP00000011502; -.
DR   PaxDb; Q3T0M2; -.
DR   PRIDE; Q3T0M2; -.
DR   Ensembl; ENSBTAT00000011502; ENSBTAP00000011502; ENSBTAG00000008730.
DR   GeneID; 508473; -.
DR   KEGG; bta:508473; -.
DR   CTD; 119559; -.
DR   VEuPathDB; HostDB:ENSBTAG00000008730; -.
DR   VGNC; VGNC:34533; SFXN4.
DR   eggNOG; KOG3767; Eukaryota.
DR   GeneTree; ENSGT01030000234641; -.
DR   HOGENOM; CLU_039425_3_0_1; -.
DR   InParanoid; Q3T0M2; -.
DR   OMA; SYTTCAG; -.
DR   OrthoDB; 881974at2759; -.
DR   TreeFam; TF313205; -.
DR   Proteomes; UP000009136; Chromosome 26.
DR   Bgee; ENSBTAG00000008730; Expressed in oocyte and 104 other tissues.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0015075; F:ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   GO; GO:1990542; P:mitochondrial transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR004686; Mtc.
DR   InterPro; IPR028825; SFXN4.
DR   PANTHER; PTHR11153; PTHR11153; 1.
DR   PANTHER; PTHR11153:SF3; PTHR11153:SF3; 1.
DR   Pfam; PF03820; SFXNs; 1.
PE   2: Evidence at transcript level;
KW   Amino-acid transport; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..313
FT                   /note="Sideroflexin-4"
FT                   /id="PRO_0000247976"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        141..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        175..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        230..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        269..289
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   313 AA;  35426 MW;  7881F075AB97D9E7 CRC64;
     MEPNVRFWIT ERQSFIQRFL QWTELLDPTN LVLSIEKIEK SRQLLLTNED ASRGDLEDKR
     IQEAWKRSLS TVHPDNSRLI PGPFRPAALL PFTAPTLFLS MLPVKSLKSM ILPQASFYTY
     STAFNIVNGN ASYDRRAHES LLLGAGVIVS STFLGLFPRL LQVRLSMNSV LSRNFIPVII
     LAQLSGMNVI ASRSLEPMRG IEVMDKEGNV IGYSRKAGTK AVKDTATSRV VLFGTSAFIP
     EVFAYFFKRT QFFLQNPWSL WTLKLSCTVL VMGLMVPVSF SVFPQIGRIQ CNELEKEIQS
     ATEETELFYN RGV