SFXN4_MOUSE
ID SFXN4_MOUSE Reviewed; 313 AA.
AC Q925N1; E9QKN7; Q5FW99;
DT 27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Sideroflexin-4 {ECO:0000303|PubMed:11274051};
GN Name=Sfxn4 {ECO:0000303|PubMed:11274051, ECO:0000312|MGI:MGI:2137680};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=11274051; DOI=10.1101/gad.873001;
RA Fleming M.D., Campagna D.R., Haslett J.N., Trenor C.C. III, Andrews N.C.;
RT "A mutation in a mitochondrial transmembrane protein is responsible for the
RT pleiotropic hematological and skeletal phenotype of flexed-tail (f/f)
RT mice.";
RL Genes Dev. 15:652-657(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Mitochondrial amino-acid transporter (By similarity). Does
CC not act as a serine transporter: not able to mediate transport of
CC serine into mitochondria (By similarity).
CC {ECO:0000250|UniProtKB:Q6P4A7, ECO:0000250|UniProtKB:Q9H9B4}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q6P4A7}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Largely restricted to kidney, brain and heart.
CC {ECO:0000269|PubMed:11274051}.
CC -!- SIMILARITY: Belongs to the sideroflexin family. {ECO:0000305}.
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DR EMBL; AF325263; AAK39431.1; -; mRNA.
DR EMBL; AC102432; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC163019; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC089535; AAH89535.1; -; mRNA.
DR CCDS; CCDS29943.1; -.
DR RefSeq; NP_444428.3; NM_053198.3.
DR AlphaFoldDB; Q925N1; -.
DR STRING; 10090.ENSMUSP00000118743; -.
DR iPTMnet; Q925N1; -.
DR PhosphoSitePlus; Q925N1; -.
DR MaxQB; Q925N1; -.
DR PaxDb; Q925N1; -.
DR PRIDE; Q925N1; -.
DR ProteomicsDB; 261201; -.
DR Antibodypedia; 18795; 126 antibodies from 21 providers.
DR DNASU; 94281; -.
DR Ensembl; ENSMUST00000135808; ENSMUSP00000118743; ENSMUSG00000063698.
DR GeneID; 94281; -.
DR KEGG; mmu:94281; -.
DR UCSC; uc008icc.2; mouse.
DR CTD; 119559; -.
DR MGI; MGI:2137680; Sfxn4.
DR VEuPathDB; HostDB:ENSMUSG00000063698; -.
DR eggNOG; KOG3767; Eukaryota.
DR GeneTree; ENSGT01030000234641; -.
DR HOGENOM; CLU_039425_3_0_1; -.
DR InParanoid; Q925N1; -.
DR OMA; SYTTCAG; -.
DR OrthoDB; 881974at2759; -.
DR PhylomeDB; Q925N1; -.
DR TreeFam; TF313205; -.
DR BioGRID-ORCS; 94281; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Sfxn4; mouse.
DR PRO; PR:Q925N1; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q925N1; protein.
DR Bgee; ENSMUSG00000063698; Expressed in CA1 field of hippocampus and 195 other tissues.
DR ExpressionAtlas; Q925N1; baseline and differential.
DR Genevisible; Q925N1; MM.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0015075; F:ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR GO; GO:1990542; P:mitochondrial transmembrane transport; IBA:GO_Central.
DR InterPro; IPR004686; Mtc.
DR InterPro; IPR028825; SFXN4.
DR PANTHER; PTHR11153; PTHR11153; 1.
DR PANTHER; PTHR11153:SF3; PTHR11153:SF3; 1.
DR Pfam; PF03820; SFXNs; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Amino-acid transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..313
FT /note="Sideroflexin-4"
FT /id="PRO_0000177042"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..247
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 173
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q6P4A7"
FT CONFLICT 115
FT /note="G -> S (in Ref. 1; AAK39431)"
FT /evidence="ECO:0000305"
FT CONFLICT 148
FT /note="S -> F (in Ref. 1; AAK39431)"
FT /evidence="ECO:0000305"
FT CONFLICT 167
FT /note="P -> L (in Ref. 1; AAK39431)"
FT /evidence="ECO:0000305"
FT CONFLICT 177
FT /note="P -> S (in Ref. 3; AAH89535)"
FT /evidence="ECO:0000305"
FT CONFLICT 194
FT /note="S -> G (in Ref. 3; AAH89535)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 313 AA; 35580 MW; A50385291DBBFA70 CRC64;
MEPNLQFWIS ERQAFFRRFC QWMDLLDPVN MFISIGSIEK SRQLLFTTED APKHYLDNQV
IKDAWNKSLS TVHPDSSKLI PHLFRPAAFL PVTAPMVFLL MMPDTGIKSI ILTQGCLYGY
TTAFNITNGN ASYSHGPVER TLLGAGVSVS STFIGLIPHL FQMKYPPNNF WLKRTLPIVF
LAQVSGMNVF ASRSFENHRG IEVMDKEGHV VGHSRKAGRK AIKDTAKSRA VLFGTSALAP
ELFIHIFKRT RFYPQTLLSL VILRMSSTFF MMGLMVPVSF SMFPQIGQIQ CSQLEEKIQS
STEEKELFYY RGV
