SFXN5_CAEEL
ID SFXN5_CAEEL Reviewed; 331 AA.
AC Q5FC79;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Sideroflexin-5 {ECO:0000305};
GN Name=sfxn-5 {ECO:0000312|WormBase:C41C4.10a}; ORFNames=C41C4.10;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Mitochondrial amino-acid transporter.
CC {ECO:0000250|UniProtKB:Q9H9B4}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC {ECO:0000250|UniProtKB:Q8CFD0}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the sideroflexin family. {ECO:0000305}.
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DR EMBL; Z48045; CAI46557.1; -; Genomic_DNA.
DR RefSeq; NP_001022022.1; NM_001026851.3.
DR AlphaFoldDB; Q5FC79; -.
DR BioGRID; 531955; 1.
DR STRING; 6239.C41C4.10; -.
DR EPD; Q5FC79; -.
DR PaxDb; Q5FC79; -.
DR PeptideAtlas; Q5FC79; -.
DR EnsemblMetazoa; C41C4.10a.1; C41C4.10a.1; WBGene00044049.
DR GeneID; 174303; -.
DR KEGG; cel:CELE_C41C4.10; -.
DR CTD; 174303; -.
DR WormBase; C41C4.10a; CE37882; WBGene00044049; sfxn-5.
DR eggNOG; KOG3767; Eukaryota.
DR GeneTree; ENSGT01030000234641; -.
DR HOGENOM; CLU_039425_2_1_1; -.
DR InParanoid; Q5FC79; -.
DR OMA; WINQSYN; -.
DR OrthoDB; 881974at2759; -.
DR PhylomeDB; Q5FC79; -.
DR PRO; PR:Q5FC79; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00044049; Expressed in larva and 3 other tissues.
DR ExpressionAtlas; Q5FC79; baseline and differential.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0015075; F:ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR GO; GO:1990542; P:mitochondrial transmembrane transport; IBA:GO_Central.
DR InterPro; IPR004686; Mtc.
DR PANTHER; PTHR11153; PTHR11153; 1.
DR Pfam; PF03820; SFXNs; 1.
DR TIGRFAMs; TIGR00798; mtc; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Membrane; Mitochondrion; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..331
FT /note="Sideroflexin-5"
FT /id="PRO_0000065233"
FT TRANSMEM 104..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..175
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..265
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..300
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 331 AA; 36992 MW; 536E12AF0E581F76 CRC64;
MALDETLFGY PIYPKFKLGE PRFPQDTFLG RYLHCLDVID PRTLFASNKK LEESLELLNS
FKAGTATNVP DKSLWEAQKL KSAILHPDTG EKVLPPFRMS GFVPFGWITV TGMLLPNPSW
PTLLFWQWMN QSHNACVNYA NRNATQPQPL SKYIGAYGAA VTAACSISGG LTYFIKKASS
LPPTTRIIIQ RFVPLPATSL ASSLNVICMR WNELETGIQV YEKDTGKVVG VSKVAAKQAV
TDTTMVRAFL PVPLLLMPPC IMPYLERFKW VTKTQVRHIF VNAIVCTLSF AVSLPVALAL
FPQESAISRE QLEPELQQKT KNSLLYYNKG L