ID   SFXN5_RAT               Reviewed;         342 AA.
AC   Q8CFD0;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Sideroflexin-5 {ECO:0000305};
DE   AltName: Full=Tricarboxylate carrier BBG-TCC {ECO:0000303|PubMed:12150972};
GN   Name=Sfxn5 {ECO:0000312|RGD:628706};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND TISSUE
RP   SPECIFICITY.
RC   TISSUE=Brain;
RX   PubMed=12150972; DOI=10.1016/s0006-291x(02)00694-0;
RA   Miyake S., Yamashita T., Taniguchi M., Tamatani M., Sato K., Tohyama M.;
RT   "Identification and characterization of a novel mitochondrial
RT   tricarboxylate carrier.";
RL   Biochem. Biophys. Res. Commun. 295:463-468(2002).
CC   -!- FUNCTION: Mitochondrial amino-acid transporter (By similarity). Does
CC       not act as a serine transporter: not able to mediate transport of
CC       serine into mitochondria (By similarity). Transports citrate
CC       (PubMed:12150972). {ECO:0000250|UniProtKB:Q8TD22,
CC       ECO:0000250|UniProtKB:Q9H9B4, ECO:0000269|PubMed:12150972}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC       {ECO:0000269|PubMed:12150972}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: Specifically expressed in the brain.
CC       {ECO:0000269|PubMed:12150972}.
CC   -!- SIMILARITY: Belongs to the sideroflexin family. {ECO:0000305}.
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DR   EMBL; AB056724; BAC15564.1; -; mRNA.
DR   RefSeq; NP_695210.1; NM_153298.1.
DR   AlphaFoldDB; Q8CFD0; -.
DR   STRING; 10116.ENSRNOP00000054347; -.
DR   iPTMnet; Q8CFD0; -.
DR   PhosphoSitePlus; Q8CFD0; -.
DR   PaxDb; Q8CFD0; -.
DR   PRIDE; Q8CFD0; -.
DR   Ensembl; ENSRNOT00000057537; ENSRNOP00000054347; ENSRNOG00000037871.
DR   GeneID; 261737; -.
DR   KEGG; rno:261737; -.
DR   UCSC; RGD:628706; rat.
DR   CTD; 94097; -.
DR   RGD; 628706; Sfxn5.
DR   eggNOG; KOG3767; Eukaryota.
DR   GeneTree; ENSGT01030000234641; -.
DR   HOGENOM; CLU_039425_2_1_1; -.
DR   InParanoid; Q8CFD0; -.
DR   OMA; WINQSYN; -.
DR   OrthoDB; 881974at2759; -.
DR   PhylomeDB; Q8CFD0; -.
DR   PRO; PR:Q8CFD0; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   Bgee; ENSRNOG00000037871; Expressed in frontal cortex and 18 other tissues.
DR   Genevisible; Q8CFD0; RN.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; IDA:RGD.
DR   GO; GO:0015137; F:citrate transmembrane transporter activity; IDA:RGD.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   GO; GO:0015746; P:citrate transport; IDA:RGD.
DR   GO; GO:1990542; P:mitochondrial transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR004686; Mtc.
DR   PANTHER; PTHR11153; PTHR11153; 1.
DR   Pfam; PF03820; SFXNs; 1.
DR   TIGRFAMs; TIGR00798; mtc; 1.
PE   2: Evidence at transcript level;
KW   Amino-acid transport; Membrane; Mitochondrion; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..342
FT                   /note="Sideroflexin-5"
FT                   /id="PRO_0000177045"
FT   TRANSMEM        105..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        256..276
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        289..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   342 AA;  37304 MW;  DC2E93A165E95F4B CRC64;
     MADTATTASA ASAAASASNA SSDAPPFQLG KPRFQQTSFY GRFRHFLDII DPRTLFVTEK
     RLREAVQLLE DYKHGTLRPG VTNEQLWSAQ KIKQAILHPD TNEKIFMPFR MSGYIPFGTP
     IVVGLLLPNQ TLASTVFWQW LNQSHNACVN YANRNATKPS PASKFIQGYL GAVISAVSIA
     VGLNVLVQKA NKFTPATRLL VQRFVPFPAV ASANICNVVL MRYGELEEGI DVLDADGNLV
     GSSKIAARHA LLETALTRVV LPMPILVLPP IVMSMLEKTA LLQARPRLLL PVHSLVCLAA
     FGLALPLAIS LFPQMSEIET SQLEPEIARA TSSRTVVYNK GL