ID   SFXN_DICDI              Reviewed;         329 AA.
AC   Q54NQ9;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Sideroflexin;
GN   Name=sfxn {ECO:0000312|dictyBase:DDB_G0285029}; ORFNames=DDB_G0285029;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Mitochondrial amino-acid transporter that mediates transport
CC       of serine into mitochondria. {ECO:0000250|UniProtKB:Q96NB2}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC       {ECO:0000250|UniProtKB:Q96NB2}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the sideroflexin family. {ECO:0000305}.
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DR   EMBL; AAFI02000073; EAL64978.1; -; Genomic_DNA.
DR   RefSeq; XP_640008.1; XM_634916.1.
DR   AlphaFoldDB; Q54NQ9; -.
DR   STRING; 44689.DDB0237548; -.
DR   PaxDb; Q54NQ9; -.
DR   EnsemblProtists; EAL64978; EAL64978; DDB_G0285029.
DR   GeneID; 8624926; -.
DR   KEGG; ddi:DDB_G0285029; -.
DR   dictyBase; DDB_G0285029; sfxn.
DR   eggNOG; KOG3767; Eukaryota.
DR   HOGENOM; CLU_039425_0_0_1; -.
DR   InParanoid; Q54NQ9; -.
DR   OMA; WINQSYN; -.
DR   PhylomeDB; Q54NQ9; -.
DR   PRO; PR:Q54NQ9; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR   GO; GO:0015075; F:ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   GO; GO:1990542; P:mitochondrial transmembrane transport; IBA:GO_Central.
DR   InterPro; IPR004686; Mtc.
DR   PANTHER; PTHR11153; PTHR11153; 1.
DR   Pfam; PF03820; SFXNs; 1.
DR   TIGRFAMs; TIGR00798; mtc; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Membrane; Mitochondrion; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..329
FT                   /note="Sideroflexin"
FT                   /id="PRO_0000350610"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        183..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        274..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   329 AA;  36158 MW;  6435FA7CD8DE95CD CRC64;
     MTSNSFPVFD GVSNKYDNNT FYGRYQNFRD ITDPSTLFAT EKDLSQSKTL LDNFKKGLVD
     PVKHSDELWK AKKILDSTIH PDTGKPIFLP FRVSAFLPIN VIICAGLILP NASIGTTIFW
     QWINQSYNIA LNHANRNASN TMSNKQILEA YASAVGISCS LAVGLGWGVN KLNIQNKTIS
     SALRMMVPFT AVTSAGIANV LIMRGNEMVN GIDIKDKDGV IHGKSKEAGK SAVYKVAFSR
     AATSFPALLL PPIVMGLFER TSFVKKYPKV RMPLNLAVIA AIFNTSLPAA IALFPQESTI
     SADSLEPQFR NIKDKNGNII KEFIYNKGL