SG11A_MOUSE
ID SG11A_MOUSE Reviewed; 71 AA.
AC Q8K4N2; Q2HPE4; Q30KM3;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 2.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Sperm-associated antigen 11A {ECO:0000312|MGI:MGI:1925378};
DE AltName: Full=Antimicrobial-like protein Bin-1b {ECO:0000250|UniProtKB:Q8VBV2};
DE AltName: Full=EP2 protein {ECO:0000250|UniProtKB:Q6PDA7};
DE Flags: Precursor;
GN Name=Spag11a {ECO:0000312|MGI:MGI:1925378};
GN Synonyms=Bin1b {ECO:0000303|Ref.2}, Ep2 {ECO:0000250|UniProtKB:Q6PDA7},
GN Ep2e {ECO:0000312|MGI:MGI:1925378}, Spag11 {ECO:0000312|MGI:MGI:1925378};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC TISSUE=Epididymis;
RX PubMed=12193721; DOI=10.4049/jimmunol.169.5.2516;
RA Yamaguchi Y., Nagase T., Makita R., Fukuhara S., Tomita T., Tominaga T.,
RA Kurihara H., Ouchi Y.;
RT "Identification of multiple novel epididymis-specific beta-defensin
RT isoforms in humans and mice.";
RL J. Immunol. 169:2516-2523(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2).
RC STRAIN=CD-1; TISSUE=Epididymis;
RA Xiao L.-Q., Li P., Liu Q., Zhang Y.-D., Zhang Y.-L.;
RT "Identification of rat Bin1b homolog in mouse.";
RL Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Epididymis;
RA Yashwanth R., Yenugu S., Hamil K.G., French F.S., Hall S.H.;
RT "Identification of novel beta-defensin isoforms in mice.";
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Epididymis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: Has antimicrobial activity against E.coli (By similarity).
CC Plays a role in the defense response in the male reproductive tract,
CC contributing to sperm maturation, storage and protection (By
CC similarity). {ECO:0000250|UniProtKB:Q8VBV2}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=Ep2q;
CC IsoId=Q8K4N2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8K4N2-2; Sequence=VSP_020138;
CC -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR EMBL; AB089183; BAC10633.1; -; mRNA.
DR EMBL; AF384173; AAQ02795.1; -; mRNA.
DR EMBL; AF384174; AAQ02796.1; -; Genomic_DNA.
DR EMBL; AY552529; AAT57924.1; -; mRNA.
DR EMBL; AK020333; BAC25623.1; -; mRNA.
DR CCDS; CCDS40252.1; -. [Q8K4N2-2]
DR RefSeq; NP_001273422.1; NM_001286493.1.
DR RefSeq; NP_694755.1; NM_153115.1. [Q8K4N2-2]
DR RefSeq; XP_006508990.1; XM_006508927.3. [Q8K4N2-2]
DR AlphaFoldDB; Q8K4N2; -.
DR STRING; 10090.ENSMUSP00000055391; -.
DR PaxDb; Q8K4N2; -.
DR PRIDE; Q8K4N2; -.
DR ProteomicsDB; 257310; -. [Q8K4N2-1]
DR ProteomicsDB; 257311; -. [Q8K4N2-2]
DR DNASU; 78128; -.
DR Ensembl; ENSMUST00000058955; ENSMUSP00000055391; ENSMUSG00000079842. [Q8K4N2-2]
DR Ensembl; ENSMUST00000212226; ENSMUSP00000148411; ENSMUSG00000110641. [Q8K4N2-1]
DR GeneID; 546038; -.
DR GeneID; 78128; -.
DR KEGG; mmu:78128; -.
DR CTD; 10407; -.
DR CTD; 653423; -.
DR MGI; MGI:1925378; Spag11a.
DR VEuPathDB; HostDB:ENSMUSG00000059463; -.
DR VEuPathDB; HostDB:ENSMUSG00000079842; -.
DR VEuPathDB; HostDB:ENSMUSG00000110641; -.
DR eggNOG; ENOG502TDV1; Eukaryota.
DR GeneTree; ENSGT00940000161432; -.
DR HOGENOM; CLU_143879_1_0_1; -.
DR InParanoid; Q8K4N2; -.
DR OMA; ACCLHQN; -.
DR OrthoDB; 1572254at2759; -.
DR TreeFam; TF338214; -.
DR BioGRID-ORCS; 546038; 3 hits in 72 CRISPR screens.
DR BioGRID-ORCS; 78128; 2 hits in 69 CRISPR screens.
DR PRO; PR:Q8K4N2; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q8K4N2; protein.
DR Bgee; ENSMUSG00000059463; Expressed in esophagus and 10 other tissues.
DR ExpressionAtlas; Q8K4N2; baseline and differential.
DR GO; GO:0001669; C:acrosomal vesicle; ISO:MGI.
DR GO; GO:0009986; C:cell surface; IDA:MGI.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR GO; GO:0019731; P:antibacterial humoral response; IDA:MGI.
DR GO; GO:0019732; P:antifungal humoral response; IDA:MGI.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; ISO:MGI.
DR GO; GO:0032690; P:negative regulation of interleukin-1 alpha production; IDA:MGI.
DR GO; GO:0032691; P:negative regulation of interleukin-1 beta production; IDA:MGI.
DR InterPro; IPR001855; Defensin_beta-typ.
DR InterPro; IPR007988; Sperm_Ag_11A_B.
DR PANTHER; PTHR14081; PTHR14081; 1.
DR Pfam; PF00711; Defensin_beta; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Antibiotic; Antimicrobial; Defensin; Disulfide bond;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..71
FT /note="Sperm-associated antigen 11A"
FT /id="PRO_0000006955"
FT DISULFID 32..61
FT /evidence="ECO:0000250"
FT DISULFID 39..54
FT /evidence="ECO:0000250"
FT DISULFID 44..62
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..20
FT /note="MIPRLLPFFASLLFAALLFP -> MKVLLLFAVFFCFVQGNS (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:12193721,
FT ECO:0000303|PubMed:16141072, ECO:0000303|Ref.2"
FT /id="VSP_020138"
FT CONFLICT 10
FT /note="A -> V (in Ref. 3; AAT57924)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 71 AA; 8116 MW; E48EA013B1416DE6 CRC64;
MIPRLLPFFA SLLFAALLFP GDIPPGIRNT VCLMQQGHCR LFMCRSGERK GDICSDPWNR
CCVPYSVKDR R
