SG11A_PANTR
ID SG11A_PANTR Reviewed; 103 AA.
AC Q9MZ28; Q9MZ27; Q9MZ29;
DT 28-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 28-FEB-2003, sequence version 2.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Sperm-associated antigen 11A {ECO:0000250|UniProtKB:Q6PDA7};
DE AltName: Full=Antimicrobial-like protein Bin-1b {ECO:0000250|UniProtKB:Q8VBV2};
DE AltName: Full=EP2 protein {ECO:0000303|PubMed:10819450};
DE Flags: Precursor;
GN Name=SPAG11A {ECO:0000250|UniProtKB:Q6PDA7};
GN Synonyms=BIN1B {ECO:0000250|UniProtKB:Q8K4N2},
GN EP2 {ECO:0000303|PubMed:10819450}, SPAG11 {ECO:0000250|UniProtKB:Q6PDA7};
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS EP2A; EP2B; EP2C AND EP2D).
RX PubMed=10819450;
RA Frohlich O., Po C., Murphy T., Young L.G.;
RT "Multiple promoter and splicing mRNA variants of the epididymis-specific
RT gene EP2.";
RL J. Androl. 21:421-430(2000).
CC -!- FUNCTION: Has antimicrobial activity against E.coli (By similarity).
CC Plays a role in the defense response in the male reproductive tract,
CC contributing to sperm maturation, storage and protection (By
CC similarity). {ECO:0000250|UniProtKB:Q8VBV2}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=EP2A {ECO:0000303|PubMed:10819450};
CC IsoId=Q9MZ28-1; Sequence=Displayed;
CC Name=EP2B {ECO:0000303|PubMed:10819450};
CC IsoId=Q9MZ28-2; Sequence=VSP_006214;
CC Name=EP2C {ECO:0000303|PubMed:10819450};
CC IsoId=Q9MZ28-3; Sequence=VSP_006215;
CC Name=EP2D {ECO:0000303|PubMed:10819450};
CC IsoId=Q9MZ28-4; Sequence=VSP_006216;
CC -!- SIMILARITY: Belongs to the SPAG11 family. {ECO:0000305}.
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DR EMBL; AF263551; AAF87718.1; -; mRNA.
DR EMBL; AF263552; AAF87719.1; -; mRNA.
DR EMBL; AF263553; AAF87720.1; -; mRNA.
DR EMBL; AF263554; AAF87721.1; -; mRNA.
DR RefSeq; NP_001103705.1; NM_001110235.1. [Q9MZ28-1]
DR RefSeq; NP_001103706.1; NM_001110236.1. [Q9MZ28-2]
DR RefSeq; NP_001103707.1; NM_001110237.1. [Q9MZ28-3]
DR RefSeq; NP_001103708.1; NM_001110238.1. [Q9MZ28-4]
DR AlphaFoldDB; Q9MZ28; -.
DR STRING; 9598.ENSPTRP00000055544; -.
DR PaxDb; Q9MZ28; -.
DR Ensembl; ENSPTRT00000037003; ENSPTRP00000034197; ENSPTRG00000019963. [Q9MZ28-3]
DR Ensembl; ENSPTRT00000043595; ENSPTRP00000039008; ENSPTRG00000019963. [Q9MZ28-2]
DR Ensembl; ENSPTRT00000047238; ENSPTRP00000046551; ENSPTRG00000019963. [Q9MZ28-1]
DR GeneID; 450159; -.
DR KEGG; ptr:450159; -.
DR CTD; 10407; -.
DR eggNOG; ENOG502TDV0; Eukaryota.
DR GeneTree; ENSGT00940000161432; -.
DR HOGENOM; CLU_178650_0_0_1; -.
DR InParanoid; Q9MZ28; -.
DR OMA; ACCLHQN; -.
DR OrthoDB; 1274696at2759; -.
DR TreeFam; TF338214; -.
DR Proteomes; UP000002277; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR InterPro; IPR007988; Sperm_Ag_11A_B.
DR PANTHER; PTHR14081; PTHR14081; 1.
DR Pfam; PF05324; Sperm_Ag_HE2; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..103
FT /note="Sperm-associated antigen 11A"
FT /id="PRO_0000033186"
FT CARBOHYD 29
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..71
FT /note="MRQRLLPSVTSLLLVALLFPGSSQARHVNHSATEALGELRERAPGQGTNGFQ
FT LLRHAVKRDLLPPRTPPYQ -> MKVFFLFAVLFCLVQTNS (in isoform
FT EP2B)"
FT /evidence="ECO:0000305"
FT /id="VSP_006214"
FT VAR_SEQ 72..103
FT /note="VHISHQEARGPSFKICVGFLGPRWARGCSTGN -> EPASDLKVVDFRRSEG
FT FCQEYCNYMETQVGYCPKKKDACCLH (in isoform EP2C)"
FT /evidence="ECO:0000305"
FT /id="VSP_006215"
FT VAR_SEQ 72..103
FT /note="VHISHQEARGPSFKICVGFLGPRWARGCSTGN -> GDVPLGIRNTICRMQQ
FT GICRLFFCHSGEKKRDICSDPWNRCCVSNTDEEGKEKPEMDGRSGI (in isoform
FT EP2D)"
FT /evidence="ECO:0000305"
FT /id="VSP_006216"
SQ SEQUENCE 103 AA; 11317 MW; ABDD0D637854A81C CRC64;
MRQRLLPSVT SLLLVALLFP GSSQARHVNH SATEALGELR ERAPGQGTNG FQLLRHAVKR
DLLPPRTPPY QVHISHQEAR GPSFKICVGF LGPRWARGCS TGN
