ID   SG11A_RAT               Reviewed;          68 AA.
AC   Q8VBV2;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Sperm-associated antigen 11A {ECO:0000312|RGD:628905};
DE   AltName: Full=Antimicrobial-like protein Bin-1b {ECO:0000303|PubMed:11230693};
DE   AltName: Full=EP2 protein {ECO:0000250|UniProtKB:Q6PDA7};
DE   Flags: Precursor;
GN   Name=Spag11a {ECO:0000312|RGD:628905};
GN   Synonyms=Bin1b {ECO:0000312|RGD:628905},
GN   Ep2 {ECO:0000250|UniProtKB:Q6PDA7}, Spag11 {ECO:0000312|RGD:628905};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, TISSUE SPECIFICITY, AND
RP   DEVELOPMENTAL STAGE.
RC   STRAIN=Sprague-Dawley; TISSUE=Epididymis;
RX   PubMed=11230693; DOI=10.1126/science.1056545;
RA   Li P., Chan H.C., He B., So S.C., Chung Y.W., Shang Q., Zhang Y.-D.,
RA   Zhang Y.-L.;
RT   "An antimicrobial peptide gene found in the male reproductive system of
RT   rats.";
RL   Science 291:1783-1785(2001).
CC   -!- FUNCTION: Has antimicrobial activity against E.coli (PubMed:11230693).
CC       Plays a role in the defense response in the male reproductive tract,
CC       contributing to sperm maturation, storage and protection
CC       (PubMed:11230693). {ECO:0000269|PubMed:11230693}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Only expressed in epididymis (middle part of the
CC       caput). {ECO:0000269|PubMed:11230693}.
CC   -!- DEVELOPMENTAL STAGE: Its expression starts at 30 days of age, reaches a
CC       maximum during the sexually mature period, and then decreased in old
CC       rats. {ECO:0000269|PubMed:11230693}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; AF217089; AAL55637.1; -; Genomic_DNA.
DR   EMBL; AF217088; AAL55636.1; -; mRNA.
DR   RefSeq; NP_659555.1; NM_145087.2.
DR   AlphaFoldDB; Q8VBV2; -.
DR   STRING; 10116.ENSRNOP00000018741; -.
DR   PaxDb; Q8VBV2; -.
DR   Ensembl; ENSRNOT00000018741; ENSRNOP00000018741; ENSRNOG00000013957.
DR   GeneID; 246305; -.
DR   KEGG; rno:246305; -.
DR   UCSC; RGD:628905; rat.
DR   CTD; 653423; -.
DR   RGD; 628905; Spag11a.
DR   eggNOG; ENOG502TDUZ; Eukaryota.
DR   GeneTree; ENSGT00940000161432; -.
DR   HOGENOM; CLU_197160_0_0_1; -.
DR   InParanoid; Q8VBV2; -.
DR   OMA; RDVICLT; -.
DR   OrthoDB; 1606260at2759; -.
DR   PhylomeDB; Q8VBV2; -.
DR   PRO; PR:Q8VBV2; -.
DR   Proteomes; UP000002494; Chromosome 16.
DR   Genevisible; Q8VBV2; RN.
DR   GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0019731; P:antibacterial humoral response; IEA:Ensembl.
DR   GO; GO:0019732; P:antifungal humoral response; IEA:Ensembl.
DR   GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR   GO; GO:0032690; P:negative regulation of interleukin-1 alpha production; IEA:Ensembl.
DR   GO; GO:0032691; P:negative regulation of interleukin-1 beta production; IEA:Ensembl.
DR   InterPro; IPR001855; Defensin_beta-typ.
DR   InterPro; IPR007988; Sperm_Ag_11A_B.
DR   PANTHER; PTHR14081; PTHR14081; 1.
DR   Pfam; PF00711; Defensin_beta; 1.
PE   2: Evidence at transcript level;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..68
FT                   /note="Sperm-associated antigen 11A"
FT                   /id="PRO_0000006956"
FT   DISULFID        30..59
FT                   /evidence="ECO:0000250"
FT   DISULFID        37..52
FT                   /evidence="ECO:0000250"
FT   DISULFID        42..60
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   68 AA;  7799 MW;  86BBCC7A5D2FA53E CRC64;
     MKVLLLFAVF FCLVQRNSGD IPPGIRNTVC FMQRGHCRLF MCRSGERKGD ICSDPWNRCC
     VSSSIKNR